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Survival outcomes differed between left-sided colon and middle/low rectal cancer post-colorectal hepatic metastasectomy. Patients with left-sided colon cancer exhibited significantly better overall survival (OS) than those with middle/low rectal cancer, especially in the subgroup analysis of ras mutations. The study suggests that middle/low rectal cancer…
Whipple over the splenic artery (WOTSA) can replace most total pancreatectomies for ductal adenocarcinoma, offering similar complication rates but improved postoperative glycemic status and potentially better disease-free survival. Results show no reoperations required in the WOTSA group due to pancreas or spleen issues, with comparable…
Study finds higher relative dose intensity (RDI) of adjuvant S-1 chemotherapy and greater psoas muscle mass volume (PMV) linked to significantly improved 5-year overall and relapse-free survival rates in patients with resected pancreatic ductal adenocarcinoma. RDI emerges as an independent prognostic factor, with patients displaying…
Robotic surgery in hepato-pancreatic-biliary procedures is feasible and valuable for minimally invasive indications. Expertise is crucial for safety, encompassing requirements for credentialing in robotics. Prioritized questions for future trials include prospective registries with validated outcome metrics. The consensus guidelines from the Robot4HPB conference highlight state-of-the-art…
An atlas of hepatocellular carcinoma revealed seven genetic evolutionary paths influencing patient clinical trajectories. Most notably, the 'bad apple' effect showed that the aggressive cell fraction within tumors predicted prognosis better than overall heterogeneity levels, reshaping how clinicians predict survival. This study highlights the importance…
Barthel Index scores below 85 indicate higher risk for adverse surgical outcomes in elderly hepatocellular carcinoma patients undergoing hepatectomy. A retrospective cohort study of 497 patients found those with lower scores had significantly lower rates of achieving textbook outcomes (TO) post-surgery compared to higher score…
Laparoscopic and robotic distal pancreatectomy are more cost-effective than open surgery, with laparoscopic surgery showing better cost savings and robotic surgery having superior surgical outcomes and improved quality-adjusted life years. Both laparoscopic and robotic approaches resulted in significantly reduced hospitalization costs compared to open surgery,…
Patients who undergo pancreatic resection face a 2.4-fold increase in pathological fractures, a 1.4-1.5 fold increase in osteoporosis/osteomalacia, and vitamin-D deficiency. Post-surgery, bone mineral density declines more rapidly compared to historical controls. Older age, pancreatic cancer, and specific surgical procedures contribute to higher rates of…
Postoperative antibiotic prophylaxis in pancreaticoduodenectomy bile duct stenting patients significantly reduced major complications such as reoperation and intensive care unit readmission. Targeted antibiotic treatment based on the biliary microbiome decreased the likelihood of developing wound infections. The study emphasizes the importance of appropriate antibiotic prophylaxis…
Comparative survival analysis of liver resection (LR), percutaneous radiofrequency ablation (PRFA), and transarterial chemoembolization (TACE) in early multinodular hepatocellular carcinoma (HCC) patients reveals LR as the preferred therapeutic option for improved survival rates at 1, 3, and 5 years. LR demonstrates superior outcomes compared to…
