Survival stratification among pancreatic cancer patients after surgery improved by combining skeletal muscle mass, immune markers, and traditional clinical factors. Nomogram based on muscle mass to BMI ratio and inflammatory markers showed superior predictive accuracy for long-term survival, suggesting potential integration into existing risk assessment tools. Journal Article by Jin J, Xiong G (…) Qin […]
Category: HPB & Spleen
Improved Management of Suspected Gallbladder Cancer Through Intraoperative Frozen Section Analysis
Using intraoperative frozen section analysis during cholecystectomy, surgeons can decide on a single-stage management approach for suspected gallbladder cancer (GBC). A retrospective cohort study of 37 consecutive cholecystectomies found that frozen section analysis had a sensitivity of 100% and a specificity of 100% for detecting GBC. This one-stage approach reduced the need for a second […]
Impact of Conversion Surgery on Patients Responding to Immunotherapy for Unresectable Biliary Tract Cancer
Conversion surgery significantly improves survival outcomes in patients with positive responses to PD-1/PD-L1 inhibitor-based combined therapy for unresectable biliary tract cancer. Median progression-free survival and overall survival were significantly longer with conversion surgery compared to continued systemic therapy alone. The estimated 3-year survival rates post-surgery are promising, highlighting the potential benefits of this intervention in […]
Impact of Hospital Volume and Risk-Standardized Mortality Rate on Complex Oncologic Surgery Outcomes
High-volume and high-performance centers had lower risk-standardized mortality rates for hepato-pancreatobiliary procedures. Redistributing patients based on risk-standardized mortality rate may save more lives compared to volume-based redistribution. These findings suggest that risk-standardized mortality rate may be a superior measure of hospital quality in complex oncologic surgery. Journal Article by Julian WT, Elshami M (…) Ocuin […]
Guidelines for Maximising Tissue Value in Intrahepatic Cholangiocarcinoma Management
Pathologists developed recommendations based on international consensus to enhance the clinical value of tissue samples in intrahepatic cholangiocarcinoma management. The guidance includes consensus statements on specimen handling, reporting content, and the need for molecular information to guide personalised therapies. These recommendations aim to standardize reporting practices and optimize tissue utilization for improved patient care. Journal […]
Transarterial Chemoembolization with Targeted Therapy and Immunotherapy Improves Outcomes in Unresectable Hepatocellular Carcinoma
Transarterial chemoembolization (TACE) combined with targeted therapy and immunotherapy (TACE-T-I) shows greater efficacy and safety compared to TACE with targeted therapy alone (TACE-T) in treating unresectable hepatocellular carcinoma (HCC). A meta-analysis of 14 studies with 2144 patients revealed that the TACE-T-I group had higher overall survival (OS) and progression-free survival (PFS), as well as a […]
Reducing Invasive Evaluations in Patients with Incidental Common Bile Duct Dilation
Endoscopic ultrasound (EUS) for incidental common bile duct (CBD) dilation revealed that only 8.3% of cases had significant findings. Researchers identified predictors including age ≥70, non-biliary-type abdominal pain, CBD diameter ≥15 mm, and prior ERCP. A novel clinical prediction model was created, scoring age, pain type, prior ERCP, and CBD dilation. A score
Interpretable machine learning-based clinical prediction model for predicting lymph node metastasis in patients with intrahepatic cholangiocarcinoma
Researchers developed and validated machine learning-based predictive models for lymph node metastasis (LNM) in intrahepatic cholangiocarcinoma (ICC) using clinicopathological data from 345 patients. The study used six machine learning algorithms, identifying the Extreme Gradient Boosting (XGB) model as the best, with an average area under the curve (AUC) of 0.908. Factors such as alcoholic liver […]
Modified Mesohepatectomy for Congenital Biliary Dilatation
Modified mesohepatectomy offers a safe and beneficial alternative to trisectionectomy for treating bilobar congenital biliary dilatation. It results in higher residual liver volume, lower parenchyma resection rate, reduced complications, and optimal long-term outcomes, making it a valuable option for patients ineligible for major hepatectomy or transplantation. Comparative Study by Jin S, Jiang N (…) Dong […]
Long-term Efficacy of Imatinib Combined with Hepatic Resection for GIST Liver Metastases
Imatinib combined with hepatic resection significantly improves overall survival in patients with gastrointestinal stromal tumor liver metastases compared to imatinib monotherapy. Achieving no evidence of disease status through surgical intervention leads to prolonged overall survival, liver-specific progression-free survival, and progression-free survival. Age ≤60 years and combination therapy were independently associated with better outcomes. Journal Article […]