A nomogram incorporating treatment data proved better than the AJCC staging system in predicting overall survival for gastroenteropancreatic neuroendocrine tumors. Key factors include sex, age, race, tumor location, and treatment modalities. Internal and external validation showed superior performance, advocating for individual risk evaluation to enhance patient outcomes and quality of life. Journal Article by Wu […]
Category: HPB & Spleen
Improved Skill Transfer with 3D-Printed Model for Laparoscopic Biliary-Enteric Anastomosis Training
A randomized controlled trial found that training with a 3D-printed model for laparoscopic biliary-enteric anastomosis led to significantly shorter operation times, higher performance scores, and greater goal achievement compared to traditional training methods. This suggests improved skill acquisition and transferability to a clinical setting with the novel simulation model. Randomized Controlled Trial by Shen J, […]
Challenges and Approaches in Treating Intraductal Papillary Neoplasms
Researchers discuss current strategies and challenges in diagnosing and treating intraductal papillary neoplasms (IPNs) of the bile duct and pancreatic duct, which are precursors to pancreatic cancer and cholangiocarcinoma. Modern imaging, biomarkers, and molecular tests are aiding in diagnosis, but treatment should be individualized based on risk assessment. Surgical intervention with chemotherapeutic agents is optimal […]
Optimizing Prediction Models for Pancreatic Fistula after Pancreatectomy
Postoperative pancreatic fistula (POPF) is a common complication following pancreatectomy, with over sixty prediction models existing primarily for pancreaticoduodenectomy. However, these models have shown suboptimal accuracy across diverse populations. Future research should focus on developing and validating prediction models for distal and central pancreatectomy, incorporating machine learning and personalized variables. Integration of novel imaging technologies […]
Impact of Adjuvant Chemotherapy on Recurrence and Survival for Adenocarcinoma from Intraductal Papillary Mucinous Neoplasia
Adjuvant chemotherapy following resection for adenocarcinoma from intraductal papillary mucinous neoplasia did not show reduced recurrence rates or improved survival outcomes in a multicenter study. Various chemotherapy regimens were not associated with superior outcomes in any high-risk subgroup, indicating that chemotherapy may not influence recurrence patterns or overall survival in these patients over a median […]
Total Neoadjuvant Therapy in Pancreatic Cancer: Undefined and Inconsistent
Researchers examined the concept of total neoadjuvant therapy (TNT) for pancreatic ductal adenocarcinoma (PDAC), finding that the term “total” is not consistently defined. Although it has gained popularity for its promise of comprehensive preoperative treatment, the current understanding and protocols vary widely, with inconsistent therapy durations and approaches. Among 7 studies reviewed, the length of […]
Minimally Invasive Approach Improves Oncological Outcomes for High-Risk Ver Patients with Intrahepatic Cholangiocarcinoma
Minimally invasive surgery for intrahepatic cholangiocarcinoma in patients at high risk of early recurrence provides better disease-free and overall survival compared to open surgery. Laparoscopic approach leads to shorter surgery-adjuvant treatment interval and higher rates of adjuvant therapy initiation within 2 months post-surgery. This study highlights the oncological benefits of laparoscopy in high-risk VER patients. […]
Feasibility and Safety of Highly Complex Liver Resections
Highly complex liver resections (HCLR) can be performed with an acceptable complication profile, similar to major non-HCLR procedures. However, HCLR is associated with increased rates of biliary complications, readmissions, and reoperations. No postoperative 90-day mortality was observed in the HCLR group. Tertiary hepato-pancreato-biliary centers should be considered for cases of questionable resectability. Journal Article by […]
Management of Infected Collections in Acute Pancreatitis: To Drain or Not Drain?
Recent literature advocates for delaying catheter drainage in acute pancreatitis, but critically ill patients with severe disease and infected peri-pancreatic collections may still benefit from drainage procedures. A retrospective review of 72 patients showed high rates of ICU admission, respiratory and renal failure, and in-hospital mortality. Until more research is done, drainage should continue to […]
Laparoscopic Liver Resection VS Radiofrequency Ablation for Small Hepatocellular Carcinoma
Patients with small hepatocellular carcinoma showed similar overall and recurrence-free survival rates whether treated with laparoscopic liver resection or radiofrequency ablation. This randomized clinical trial suggests that percutaneous radiofrequency ablation may offer comparable therapeutic effects to laparoscopic liver resection for this patient population. Journal Article by Song J, Cao L (…) Zheng S et 4 […]