The EPA for Metastasis Trial 2 (EMT2) study protocol aims to address the need for safe and cost-effective adjunctive treatment for advanced colorectal cancer (CRC). The trial evaluates the effect of EPA on CRC outcomes in patients undergoing liver resection surgery for CRC liver metastasis. The primary endpoint is CRC progression-free survival, with key secondary […]
Category: HPB & Spleen
Long-term Survival Outcomes of Liver Resection for Metastatic Anal Squamous Cell Carcinoma
The study evaluated the outcomes of liver resection in patients with metastatic anal squamous cell carcinoma (SCC) to the liver. Among the 21 patients undergoing liver resection and/or ablation, 95% had undergone the Nigro protocol for the primary tumor, with 57% experiencing a complete response. The median overall survival was 32.2 months, and the 5-year […]
Multidisciplinary Treatment Guidelines for Hepatocellular Carcinoma in Italy: Surgical Treatments and Expert Collaboration.
The Italian scientific societies involved in hepatocellular carcinoma (HCC) management have collaborated to create updated treatment guidelines using evidence-based methods. This study presents the first part of the guidelines, focusing on the surgical treatments and expert tumor board collaboration for HCC. HCC is the third most common cause of cancer-related death worldwide, and the complexity […]
Robotic Enucleation for Challenging Pancreatic Head Insulinomas
The results of this study demonstrate that robotic enucleation is a safe and feasible treatment option for pancreatic head insulinomas located in challenging areas. The use of intraoperative ultrasound and endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic duct stent placement were key components in preserving the pancreatic duct during surgery. Both patients experienced successful resolution of […]
Age-adjusted Charlson Comorbidity Index is an Independent Prognostic Factor for Hilar Cholangiocarcinoma Patients Undergoing Laparoscopic Resection
The prognostic value of age-adjusted Charlson comorbidity index (ACCI) in laparoscopic resection for hilar cholangiocarcinoma was assessed in this study. Data from 136 patients undergoing laparoscopic resection were analyzed, and ACCI scores were divided into high and low groups. Higher ACCI scores (ACCI > 4.0) were found to be an independent risk factor significantly impacting […]
Identification of Lymph Node Stations Relevant to Pancreatic Cancer Using Sectioned Images and 3D Models
Researchers utilized true color and high-resolution sectioned images of a cadaver with pancreatic cancer to enhance the understanding of lymph node stations in pancreatic cancer surgery. Through the images and 3D models, they successfully identified 21 out of the known 28 lymph node stations based on location, size, and color. The remaining five stations were […]
Adjuvant Therapy Timing Impact on PDAC Prognosis: Significance in Transitional Circulating Tumor Cells
The study found that a delay in the initiation of adjuvant therapy in patients with pancreatic ductal adenocarcinoma (PDAC) is associated with worse recurrence-free survival only in those who have transitional circulating tumor cells (trCTCs) after surgical resection. The presence of trCTCs and the absence of adjuvant therapy were both linked to poorer prognosis. However, […]
Total Pancreatectomy with Islet Autotransplantation: A Safer Alternative to Pancreaticoduodenectomy in High-risk Patients
In a prospective randomized trial, researchers compared pancreaticoduodenectomy (PD) and total pancreatectomy (TP) with islet autotransplantation (IAT) in high-risk patients. They found that TP-IAT had a lower morbidity rate and shorter postoperative stay compared to PD. PD was associated with a higher risk of complications, while TP-IAT had a higher risk of diabetes. However, most […]
Laparoscopic pancreatoduodenectomy (LPD) is feasible and as safe and efficient as open pancreatoduodenectomy (OPD) when performed by highly skilled surgeons in high-volume centers
LPD and OPD were compared in this study, and it was found that LPD is feasible and equally safe and efficient as OPD when performed by highly skilled surgeons in high-volume centers. LPD has a shorter length of hospital stay, shorter ICU stay, lower blood loss, lower blood transfusion rate, and lower surgical site infection […]
Definition of Textbook Outcome in Liver Surgery (TOLS)
Renowned international liver surgeons achieved consensus on the definition of Textbook Outcome in Liver Surgery (TOLS) using a modified Delphi method. The TOLS definition includes the absence of intraoperative incidents, postoperative complications, bile leakage, liver failure, readmission due to major complications, mortality within 90 days, and the presence of a clear resection margin. This consensus-based […]