A predictive model for lymph node metastases (lnm) in intrahepatic cholangiocarcinoma patients undergoing adequate lymphadenectomy has been developed, revealing significant associations with preoperative CA 19-9 levels, suspicious lymph nodes, patient age, and tumor burden score. Analysis of 693 patients resulted in a model with high predictive accuracy, demonstrated by c-statistics of 0.723 and 0.771 in […]

A recent expert consensus from Chinese authorities presents a comprehensive framework for managing hepatocellular carcinoma (HCC) patients, addressing the complexities posed by chronic liver disease. The 2023 guidelines include 18 recommendations focusing on diagnosis, treatment, and follow-up. These pathways encompass both surgical and nonsurgical strategies, incorporating perioperative care, systematic and local treatment combinations, and tailored […]

Online preoperative and postoperative risk scores have been developed and validated for predicting early recurrence in patients with hepatocellular carcinoma (HCC) undergoing conversion liver resection after treatment with tyrosine kinase inhibitors and immune checkpoint inhibitors. The preoperative model identified key factors, achieving a c-index of 0.681, while the postoperative model scored 0.706. Both models demonstrate […]

Carboxypeptidase Z (CPZ) emerges as a promising diagnostic biomarker for hepatocellular carcinoma (HCC), showing a remarkable 90.8% positive expression rate in a study of tumor tissues. In combination with other markers, CPZ achieved sensitivities up to 79.2% and specificities near 100%. Notably, it outperformed other markers in poorly differentiated HCC, suggesting its potential role in […]

A study examining 715 patients undergoing liver resection for hepatocellular carcinoma and intrahepatic cholangiocarcinoma found that the lymphocyte-C-reactive protein ratio (LCR) could accurately predict postoperative complications, recurrence-free survival, and overall survival. An optimal LCR cutoff of 6100 was established, with lower levels associated with increased morbidity and worse survival outcomes. The findings, validated in an […]

Achievements in textbook outcomes (TO) for pancreatic surgery rose from 47% to 80.7% post-establishment of a specialized unit, indicating better surgical quality. Patients who met TO criteria showed notable overall survival rates at 1, 2, and 3 years: 86.9%, 55.7%, and 41%, compared to 62.7%, 40.3%, and 31.3% for those who did not (p=.013). Multivariate […]

A novel prognostic nomogram was developed to assess cancer-specific survival (CSS) in patients with distant-metastatic hepatocellular carcinoma (dm-hcc). Using data from 651 patients, the model identified key predictors: alpha-fetoprotein levels, tumor grade, T stage, and treatment types. The nomogram achieved a c-index of 0.721 and 0.726 in training and validation sets, respectively, demonstrating strong predictive […]