A novel predictive and prognostic signature, named chemoresist, was developed to assess the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) post-surgery and adjuvant chemotherapy. In a multicohort analysis, significant survival differences were noted between high and low chemoresist patients, with median overall survival reaching 42 months in low chemoresist groups, compared to just 17 […]
Category: HPB & Spleen
Omitting abdominal drains improves outcomes after left pancreatectomy
A systematic review and meta-analysis involving 15,817 patients revealed that avoiding routine abdominal drainage following left pancreatectomy significantly reduces major morbidity, postoperative pancreatic fistula rates, readmissions, and surgical site infections. The no-drain group experienced a 23% reduction in major complications and substantially lower rates of fistulas and infections. Additionally, patients without drains had shorter hospital […]
Early recurrence significantly worsens survival in HCC patients.
A multicenter study involving 2828 patients with hepatocellular carcinoma (HCC) and microvascular invasion revealed that early recurrence (ER) occurs more frequently within the first year after hepatectomy, leading to poorer outcomes than late recurrence (LR). Median overall survival was 20.2 months for ER compared to 52.6 months for LR. Regular postoperative surveillance significantly improved overall […]
Individualized strategies improve survival in metastatic rectal cancer
An extent-based tailored strategy for managing rectal cancer with synchronous resectable liver metastases achieved an 82% complete resection rate in a study involving 83 patients. Over a median follow-up of 43 months, the median overall survival reached 58 months, with one- and three-year survival rates at 94% and 73%, respectively. Multivariate analysis highlighted complete resection […]
Surgery, IORT, and PVC Improve Survival for HCC Patients
A novel triple therapy combining surgery, intraoperative radiotherapy (IORT), and postoperative PVC significantly enhances survival for hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombosis (MPVTT). A retrospective study of 56 patients revealed the surgery-IORT-PVC group achieved superior median overall survival (not reached vs. 7 months) and median progression-free survival (not reached vs. 4 […]
Single-layer pancreaticojejunostomy may lower complication rates
A meta-analysis of ten studies involving 1,811 patients found that single-layer pancreaticojejunostomy (PJ) is associated with a significantly reduced rate of clinically relevant postoperative pancreatic fistula (cr-popf) compared to double-layer PJ. The single-layer approach demonstrated a lower grade B popf rate and a consistent trend of reduced complications across various subgroups, including those defined by […]
Predictive model enhances decision-making in gallbladder cancer surgeries
A study involving 788 gallbladder cancer patients identified key predictors of futile up-front surgery, defining futile cases as those resulting in early recurrence or death post-operation. Among patients, 13.6% experienced futile outcomes, with a stark median survival of 6.8 months versus 57.4 months for non-futile cases. Major risk factors included advanced tumor stage, lymph node […]
High accuracy in predicting clean common bile ducts
A study involving 584 acute biliary pancreatitis patients revealed that age, gamma-glutamyl transferase, alkaline phosphatase, and direct bilirubin levels significantly correlate with choledocholithiasis presence. The determined cut-off values indicated a 97% negative predictive value for a clean common bile duct when all four parameters were below thresholds. Consequently, unnecessary imaging could be minimized, leading to […]
Laparoscopic navigation improves outcomes in liver surgery
Laparoscopic portal territory fluorescence navigation-guided anatomical liver resection (LPTAR) outperforms classic anatomical resection (CAR) for hepatocellular carcinoma (HCC) patients. In a study of 234 patients, those undergoing LPTAR demonstrated significantly wider resection margins, reduced blood loss, and fewer postoperative complications compared to CAR. Furthermore, the recurrence-free survival rates at 1, 3, and 5 years were […]
Endoscopic techniques may enhance palliative care for pancreatic cancer
Significant advancements in endoscopic techniques for managing malignant biliary and gastric outlet obstruction in pancreatic cancer patients provide promising alternatives to traditional surgical bypass. Emerging evidence suggests that endoscopic ultrasound-guided methods, including biliary drainage and gastroenterostomy, may outperform conventional approaches, addressing symptom relief more effectively. These developments highlight the necessity for improved palliative strategies as […]