Pancreatic cancer remains a leading global cause of death, exacerbated by aging demographics and rising risk factors like obesity and smoking. Despite its generally poor prognosis, advancements in treatment have emerged, particularly through neoadjuvant therapies, targeted therapies based on genetic testing, and immune checkpoint inhibitors. Minimally invasive surgical techniques have enhanced the safety and efficacy […]

A systematic review and meta-analysis comparing liver resection (LR) and radiofrequency ablation (RFA) for solitary hepatocellular carcinoma (HCC) ≤3 cm highlights that LR offers superior overall survival, disease-free survival, and recurrence-free survival compared to RFA, particularly for lesions ≤2 cm. While no significant differences were found in randomized controlled trials, cohort studies indicated LR’s advantages, […]

Recent findings reveal that external-beam radiation therapy (EBRT) significantly enhances patient outcomes in hepatocellular carcinoma, addressing critical care gaps. Randomized trials show that EBRT boosts overall survival and recurrence-free survival compared to conventional treatments, particularly when combined with sorafenib. Additionally, it improves the quality of life for patients with painful tumors. As technology advances, guidelines […]

A systematic review and meta-analysis revealed five significant risk factors linked to failure in achieving textbook outcomes following pancreatoduodenectomy. Key contributors include preoperative biliary drainage, smaller tumor size, soft pancreatic texture, small pancreatic duct diameter, and increased intraoperative blood loss. These findings, synthesized from ten studies involving over 5,000 patients, aim to assist surgeons in […]

The novel two-stage laparoscopic algorithm evaluated in 40 patients with suspected gallbladder cancer demonstrated safety and feasibility. Procedures included laparoscopic whole-layer cholecystectomy for early-stage lesions and gallbladder bed resection for uncertain borders. Median operation time was 165 minutes with minimal blood loss, and no bile leakage occurred. Histological evaluation confirmed gallbladder cancer in 16 patients, […]

The analysis of over 20,000 patients undergoing left pancreatectomy revealed an overall ideal outcome rate of 59.1%, with significant variation across North America, Germany, the Netherlands, and Sweden. Minimally invasive procedures yielded notably higher ideal outcomes (65.4%) compared to open surgeries (53.3%). Postoperative pancreatic fistula rates showed the largest discrepancies between regions, emphasizing differing surgical […]

A real-world safety analysis of histotripsy in 230 liver tumor patients revealed a low complication rate of 5.2%, with the majority classified as minor. Complications greater than grade II were rare, occurring in just 1.3% of cases. This novel non-invasive ultrasound technology, approved by the FDA, demonstrates a favorable safety profile in comparison to existing […]

Racial disparities in pancreatic cancer survival are linked to distinct immune microenvironments and genomic profiles. In a comprehensive analysis of 4,679 pancreatic adenocarcinoma samples, African American patients exhibited a higher frequency of TP53 mutations than European Americans. Additionally, gene expression profiling indicated significant immunologic differences between the two groups. These findings suggest that understanding these […]

A multicenter analysis of 556 patients with intraductal papillary mucinous neoplasms indicated that epithelial types significantly affect postoperative results. The pancreatobiliary type demonstrated a notably higher 10-year cumulative incidence of metachronous pancreatic ductal adenocarcinoma (22.7%) and high-risk lesions (37.2%) compared to gastric and intestinal types. Five-year disease-specific survival rates varied substantially, with 76.1% for the […]