An international consensus has established a complexity and experience grading system to guide patient selection for minimally invasive pancreatoduodenectomy (mipd). This system categorizes patient-related risk factors and surgeon experience, enhancing decision-making in surgical procedures. The grading system is designed to mitigate the challenges in adopting mipd globally by emphasizing appropriate patient selection based on defined […]

A post-hoc analysis of 588 patients revealed that while robot-assisted pancreatoduodenectomy (rpd) incurs initial higher costs compared to open pancreatoduodenectomy (opd), outcomes improve significantly with experience. Total hospital stay shortened from 12 to 9 days, and costs per rpd procedure decreased from €32,836 to €21,778. By the second half of the study, total costs for […]

Significant metabolic alterations and the dynamics of GLP-1 and GLP-2 were identified during liver resection in patients, particularly linking these changes to posthepatectomy liver failure (PHLF). Of the patients studied, metabolic clustering showed that 93% of PHLF individuals fell within one cluster. Preoperative GLP-1 levels were notably elevated in PHLF patients, and its incorporation into […]

Aptamer-decorated milk-derived nanovesicles (mnvs) effectively targeted cholangiocarcinoma (cca) cells, promoting the delivery of short interfering RNAs (siRNAs) that inhibited key gene expressions. This selective uptake led to reduced tumor growth and increased reactive oxygen species production. Notably, the combined treatment with nanovesicles and chemotherapy showed enhanced therapeutic efficacy in both immunocompetent and patient-derived xenograft models. […]

Neoadjuvant therapy changes the prognostic landscape for patients with resected pancreatic ductal adenocarcinoma (PDAC). In a study of 2,760 patients, independent predictors of overall survival (OS) differed significantly: chemotherapy-naïve patients were affected by age, CA19-9 levels, and tumor stage, while neoadjuvant therapy patients faced challenges like CA19-9 normalization and nodal presence. These insights led to […]

A novel ALBI-GGT score was developed to enhance prognostic accuracy for patients undergoing hepatocellular carcinoma (HCC) resection. This composite score combines the albumin-bilirubin and gamma-glutamyl transferase metrics, showing superior predictive ability for long-term survival compared to either measure alone. In multivariable analysis, both components significantly predicted overall mortality, with the ALBI-GGT score achieving the highest […]

A retrospective cohort study revealed that antiviral therapy (AVT) markedly reduces late recurrence rates in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and compensated cirrhosis post-hepatectomy. The 1-, 3-, 5-, and 10-year recurrence rates for the AVT group were significantly lower than those of the non-AVT group (26%, 49%, 65%, and 76% vs. […]

A comprehensive review found that the main pancreatic duct diameter and pancreatic texture are critical for predicting postoperative pancreatic fistula, while age and ASA score are significant for other complications. Of 90 studies evaluated, only 26% of risk stratification tools had external validation, with even fewer (20%) for artificial intelligence models. The findings emphasize the […]