Tumor-derived organoids have emerged as crucial tools in diagnosing and modeling primary liver cancers, particularly hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Among 39 studies analyzed, most organoids were patient-derived, showcasing their role in biomarker discovery and therapeutic exploration. Innovative approaches like organoid-on-a-chip systems suggest promising advancements in treatment regimens. These findings underline the importance of personalized […]
Category: HPB & Spleen
Genetic mutations influence survival in intrahepatic cholangiocarcinoma patients
Analysis of 24 studies revealed that mutations in kras, idh1/2, and tp53 significantly affect long-term survival outcomes in patients with resectable intrahepatic cholangiocarcinoma. Specifically, kras mutations increased the risk (HR: 2.476), while idh1/2 mutations suggested a protective effect (HR: 0.624). tp53 mutations also indicated a higher risk (HR: 2.771). Notably, the prevalence of kras and […]
Early Postoperative Recurrence Peaks at 6 Months for CRLM Patients
A study of 1,804 patients after curative resection of colorectal liver metastases revealed a median recurrence-free survival of 19.9 months, with the highest recurrence risk occurring at approximately 6 months post-surgery. The hazard curve peaked at 5.9 months, indicating a need for closer postoperative monitoring, especially in patients with high and medium tumor burdens who […]
Overweight patients face higher postoperative complications after surgery.
A study investigating laparoscopic pancreaticoduodenectomy outcomes found that overweight patients showed significantly higher incidences of clinically relevant postoperative pancreatic fistula and delayed gastric emptying compared to normal-weight counterparts. However, no differences in perioperative mortality or long-term survival rates were observed between the two groups. The study analyzed data from 432 patients, concluding that while laparoscopic […]
Safe and feasible simultaneous minimal invasive resections demonstrated
A study assessing simultaneous minimally invasive resections of colorectal liver metastases and primary tumors found the procedure to be safe and feasible. Out of 281 patients, 11.7% underwent this approach, primarily affecting rectal tumors. Notably, no anastomotic leakages occurred post-resection, with complication rates remaining consistent regardless of surgical difficulty. These findings suggest that the indications […]
Enhanced recovery protocol lowers postoperative complications in liver surgery
The enhanced recovery after surgery (ERAS) protocol significantly reduced overall postoperative complications in liver cancer patients undergoing hepatectomy. Analysis of twelve studies with 1,892 participants revealed lower odds ratios for complications, including Clavien-Dindo grade 1-2 (OR=0.39) and pneumonia (OR=0.34). Additional benefits included decreased intraoperative blood loss and duration of abdominal drain. Importantly, ERAS did not […]
Society of Radiologists in Ultrasound (SRU) guidelines reduce gallbladder surgery and costs significantly
A comparison of clinical guidelines for managing gallbladder polyps reveals marked differences in recommended actions. Researchers found that adherence to Society of Radiologists in Ultrasound (SRU) guidelines resulted in 16.9% of patients undergoing immediate surgery compared to 52.5% under European guidelines. Additionally, the SRU approach suggested ultrasound as a reasonable next step for 42.4% versus […]
New guidelines enhance systemic therapy for hepatocellular carcinoma
Updated clinical practice guidelines provide evidence-based recommendations for systemic therapy in hepatocellular carcinoma management. Researchers highlight the introduction of new targeted therapies and immune-checkpoint inhibitors to address critical issues, including recurrence after curative treatment and disease progression among patients ineligible for other therapies. Enhanced understanding of immune-related adverse events contributes to improved patient management. This […]
Early surgery outperforms endoscopy in chronic pancreatitis patients
A long-term follow-up study reveals that early surgery significantly reduces pain and enhances patient satisfaction compared to an endoscopy-first approach in chronic pancreatitis patients. After an average of 98 months, the early surgery group reported lower pain scores (33 vs. 51) and a higher rate of complete pain relief (45% vs. 20%). Additionally, satisfaction with […]
Two predictive models for HCC recurrence developed successfully
A study identified a 70.9% postoperative recurrence rate for type iii-iv in hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion. Key independent risk factors included young age, large tumor size (≥10 cm), and high Ki67 index. Two nomograms—pre- and postoperative—demonstrated strong prediction capabilities with ROC curve areas of 0.827 and 0.891, respectively. Both models effectively […]