Adjuvant therapy markedly enhances overall survival (OS) and disease-free survival (DFS) in patients post-pancreaticoduodenectomy for distal cholangiocarcinoma. A meta-analysis of 22 studies involving 7,078 patients revealed an OS hazard ratio of 0.80 and a DFS hazard ratio of 0.84 for adjuvant therapy compared to follow-up alone. Notably, combined chemo-radiotherapy yielded the best outcomes, though high […]

A study of 790 patients with advanced pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CC) reveals strong mutation concordance (MCR) between circulating tumor DNA (ctDNA) and tissue next-generation sequencing (NGS). In PDAC, 65.4% showed shared alterations, while CC had 66.7%. Additionally, ctDNA could signal resistant clones: increased TP53 variant frequencies correlated with a greater likelihood of […]

Child-Pugh scores reveal a sharp correlation between liver function and surgical outcomes in gastrointestinal cancer patients. Among 167,680 surgeries analyzed, those with a score of 9 faced significantly increased surgical mortality—31.8% after distal gastrectomy and 20.7% after right hemicolectomy. Even after adjusting for risk factors, these patients exhibited much higher mortality rates compared to those […]

Nearly 46% of hepatocellular carcinoma patients exhibited circulating tumor cells (CTCs) in the portal vein, surpassing hepatic vein detection rates. Portal vein CTC positivity linked to microscopic invasion, significantly reducing disease-free and overall survival. Notably, PD-L1-positive CTCs in this cohort correlated with dire prognoses. These findings underscore portal vein CTCs as critical prognostic biomarkers and […]

Surgical treatment significantly improves overall, 1-year, and 3-year survival rates for metastatic pancreatic adenocarcinoma, particularly in patients with liver-only metastases. Compared to chemotherapy and palliative care, surgical options reduce mortality risk (HR: 0.42). Despite promising results, outcomes vary based on metastatic sites, with no survival benefit observed for lung-only metastases. Further prospective trials are essential […]

The Fib-3 index demonstrates superior accuracy in predicting liver fibrosis and long-term outcomes in hepatocellular carcinoma patients over 65. An independent risk factor for recurrence-free survival, it outshines the conventional Fib-4 index by eliminating age-related biases. Effective risk stratification for 5-year survival hinges on its application alongside specific cutoff values, positioning the Fib-3 index as […]

Surgical intervention for pancreatic adenocarcinoma markedly enhances survival rates in patients at all stages, except for those classified as stage IV with T4 or N1 classifications. A deep learning model, DeepSurv, demonstrated a robust c-index of 0.85 in predicting survival, with surgery notably lowering mortality risks. Importantly, M stage emerged as the top mortality predictor, […]

Patients with high pre-treatment CA19-9 levels show significantly poorer prognoses than those with normal levels. Neoadjuvant treatment (NAT) markedly enhances survival for these patients, with optimal outcomes for those achieving normalized CA19-9 or sufficient reduction post-treatment. Stratification reveals that patients with levels under 296 u/ml and over 40% reduction mirror the prognosis of those with […]

A newly validated nomogram accurately predicts postoperative recovery outcomes for patients undergoing pancreaticoduodenectomy for invasive intraductal papillary mucinous neoplasm (IPMN). Analyzing data from 479 patients, it identifies four key predictors: severe COPD, hypertension, elevated INR, and prolonged operative time, achieving a textbook outcome in roughly half the cases. This tool enhances preoperative planning and risk […]