A novel Diabetes Remission Index (DRI) and Weight Loss-Adjusted Diabetes Remission Index (W-DRI) were developed to predict remission rates for type 2 diabetes following metabolic and bariatric surgery. In internal validation, the DRI model achieved an AUC of 0.80 with a 44.7% remission rate, while the W-DRI improved accuracy to 0.82. External validation confirmed similar […]
Category: Metabolic and Bariatric Surgery
Bariatric surgery significantly reduces mortality in MASLD patients
Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and cirrhosis experience significantly lower long-term mortality rates after bariatric surgery, particularly with laparoscopic techniques. A study in California analyzed data from 91,708 patients, revealing that those who underwent bariatric surgery had a 5-year overall mortality rate of 24.9%, compared to 37.1% for non-surgical patients. Laparoscopic procedures […]
Hiatal sling technique reduces liver injury in surgeries
The hiatal sling liver retraction technique has shown promising results in bariatric and upper gastrointestinal surgeries, significantly reducing liver enzyme elevation compared to the traditional Nathanson retractor. Among 1,874 surgeries, only two cases experienced difficulties, with no liver injuries or adverse effects reported. This technique offers adequate exposure while minimizing insults to the liver, enhancing […]
At-risk populations for complications in metabolic bariatric surgery identified.
The study analyzed 973,520 cases of metabolic and bariatric surgery, revealing that conditions such as GERD, COPD, smoking, and specific surgical procedures significantly heighten the risk of inpatient postoperative care (IP-POC) needs. Male patients exhibited increased severity but lower likelihood of complications, while Black and Hispanic patients faced higher risks. Scoring thresholds for IP-POC have […]
Roux-en-Y Gastric Bypass shows significant benefits for diabetes patients
A meta-analysis of ten randomized controlled trials demonstrated that Roux-en-Y gastric bypass (RYGB) significantly enhances outcomes for patients with type 2 diabetes mellitus (T2DM). Key findings revealed improved compliance rates, higher remission rates, and reductions in glycated hemoglobin (HbA1c) and fasting blood glucose levels. Additionally, participants experienced substantial weight loss, better lipid profiles, and lower […]
Sleeve Gastrectomy Outperforms Semaglutide for Weight Loss
In a study comparing weight loss outcomes between sleeve gastrectomy (SG) and semaglutide in a minority population, SG demonstrated superior weight loss after 12 months. The cohort, primarily consisting of African American (67%) and Hispanic (21%) patients with a mean BMI of 55 kg/m², included 206 participants. Results indicated that semaglutide may be less effective […]
Improved survival linked to histological remission post-bariatric surgery
Histological remission of metabolic dysfunction-associated steatohepatitis (MASH) and significant fibrosis enhances survival rates post-bariatric surgery. In a cohort of 3028 patients over a median follow-up of 10.1 years, those with persistent MASH or worsening fibrosis exhibited increased mortality, while those whose MASH resolved without fibrosis worsening showed no increased risk. Survival was significantly prolonged in […]
Sleeve gastrectomy improves outcomes for obesity and sleep apnea.
A meta-analysis revealed that sleeve gastrectomy (SG) significantly reduces the apnea-hypopnea index (AHI), body mass index (BMI), weight, and fat areas while enhancing forced vital capacity (FVC) and sleep metrics in patients with obesity and obstructive sleep apnea (OSA). Key post-surgical benefits included decreased arousal index, oxygen desaturation index (ODI), and improvements in metabolic markers […]
Identification of six hub genes for NAFLD treatment
Comprehensive machine learning facilitated the identification of 12 consensus predicted genes (CPGs) linked to non-alcoholic fatty liver disease (NAFLD) following metabolic and bariatric surgery (MBS). A mouse model confirmed the mRNA expression of six hub genes—PPARA, PLIN2, MED13, INSIG1, CPT1A, and ALOX5AP—showing strong correlations with data from three validation datasets. These findings highlight the potential […]
Sleeve gastrectomy reduces all-cause mortality compared to RYGB.
In adults with morbid obesity, sleeve gastrectomy (SG) significantly lowers all-cause mortality risks during follow-up compared to Roux-en-Y gastric bypass (RYGB). A systematic review and meta-analysis of 22 studies involving 333,713 patients revealed that SG is linked to reduced reoperation, reintervention, and hospitalization rates, although it has a higher revision rate. These findings underscore the […]