In metastatic Grade 1 gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs), a higher burden of liver disease significantly reduces progression-free survival (PFS). Patients with concomitant extra-hepatic involvement have a lower overall survival (OS) rate. Liver tumor burden emerged as the sole predictor of PFS. These findings suggest a need for more aggressive treatment strategies in metastatic Grade 1 […]
Category: Sarcoma & rare tumors
Endoscopic Ultrasonography for Residual Rectal Neuroendocrine Tumor Diagnosis
Endoscopic ultrasonography (EUS) is a sensitive method for identifying residual rectal neuroendocrine tumors (NETs) post-resection. EUS detection, with a high sensitivity of 94%, is superior to visual detection. Salvage endoscopic treatment, incorporating EUS, is safe and effective in managing incompletely resected NETs, with no recurrence observed in patients during follow-up. EUS shows promise in accurately […]
Minimally Invasive Surgery for Pancreatic Neuroendocrine Tumors
Minimally invasive surgery for left pancreatic resection in patients with resectable pancreatic neuroendocrine tumors reduces major complications and offers comparable long-term oncologic outcomes. A study comparing minimally invasive and open surgery showed lower rates of major morbidity, postoperative complications, and better outcomes with minimally invasive surgery. This suggests that minimally invasive surgery can be safely […]
Gender Impact on Survival in Small Intestinal Stromal Tumors
Male patients with small intestinal stromal tumors (SISTs) have a higher risk of mortality compared to females. Females exhibit superior overall survival and cancer-specific survival rates than males. Surgical intervention significantly improves survival outcomes in both genders. Gender, along with age, grade, TNM stage, surgery, and mitotic rate, serves as a predictive indicator for survival […]
Improved Patient Outcomes with SPARC Collaboration
Establishing the SPARC program led to improved patient outcomes for retroperitoneal sarcoma at RPAAH and COBLH. The program saw an increase in operations from 15 to 35 cases annually, with liposarcomas and leiomyosarcomas being the most common types resected. The majority of cases underwent extended resections, resulting in a high rate of R0/R1 resections. Collaboration, […]
Comparable Long-Term Survival Prognoses in Gastrointestinal Neuroendocrine Neoplasms
Endoscopic treatment and surgery show similar overall and cancer-specific survival rates in gastrointestinal neuroendocrine neoplasms. Endoscopic treatment may offer a better cancer-specific survival in certain cases such as stage I tumors and those smaller than 10mm. Both treatment options are viable for patients, with endoscopic treatment as a potential alternative for those hesitant about surgery. […]
Similar Long-Term Survival in MIS for Ileal NETs
Minimally invasive surgery (MIS) shows comparable long-term survival outcomes to open surgery for ileal neuroendocrine tumors (i-NETs), with no significant difference in overall survival rates at around 99 to 103 months follow-up. MIS is a viable alternative for i-NETs resection, especially in cases without bulky mesenteric masses or concurrent liver resections. The study suggests MIS […]
Multidisciplinary Approach Boosts Surgical Outcomes for Retroperitoneal Sarcomas in India
Establishing a dedicated multidisciplinary tumor board significantly improved surgical outcomes for retroperitoneal sarcoma patients. The post-clinic era saw a marked increase in annual surgeries from 16.3 to 42.4 (p = 0.001), and a rise in complex resections (49% vs. 18.2%; p = 0.0001). These changes underscore the importance of standardized management protocols and collaborative care […]
### Title
Meta-analysis findings show that neoadjuvant imatinib achieves high 1-year, 3-year, and 5-year overall survival rates of 100%, 94%, and 88%, respectively. Patients with gastric and rectal tumors benefit most with an 8-month treatment duration. Additionally, mutational analysis can aid in treatment decision-making. Effective outcomes include an 89% R0 resection rate and a 67% disease response […]
MRI Predicts Histological Grades in Soft Tissue Sarcomas
MRI effectively predicts histological grades of soft tissue sarcomas. Peritumoral high-intensity T2-weighted signals and peritumoral postcontrast enhancement are valuable indicators of high-grade tumors. The study’s findings highlight the importance of MRI in treatment decision-making for sarcoma patients, with each score point increment doubling the chance of high-grade tumors. Journal Article by Marques TMDM, Cerqueira WS […]