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Best Papers in General Surgery
The five that matter, every day.
A prospective cohort study involving 66 patients with ultra-low rectal cancer revealed that colonic j-pouch reconstruction significantly enhances bowel function and quality of life compared to direct anastomosis. At all postoperative intervals (1, 3, and 6 months), patients who received the j-pouch exhibited superior LARS…
A multicenter study involving 2828 patients with hepatocellular carcinoma (HCC) and microvascular invasion revealed that early recurrence (ER) occurs more frequently within the first year after hepatectomy, leading to poorer outcomes than late recurrence (LR). Median overall survival was 20.2 months for ER compared to…
An extent-based tailored strategy for managing rectal cancer with synchronous resectable liver metastases achieved an 82% complete resection rate in a study involving 83 patients. Over a median follow-up of 43 months, the median overall survival reached 58 months, with one- and three-year survival rates…
A study of 32,280 emergency general surgery patients revealed that surgical intervention led to lower risk-adjusted inpatient mortality rates compared to nonoperative management, despite the surgical group experiencing higher complication odds and longer hospital stays. Younger patients and those without preexisting conditions were more likely…
A novel triple therapy combining surgery, intraoperative radiotherapy (IORT), and postoperative PVC significantly enhances survival for hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombosis (MPVTT). A retrospective study of 56 patients revealed the surgery-IORT-PVC group achieved superior median overall survival (not reached vs.…
Elevated myoglobin levels in trauma patients correlate significantly with the development of coagulopathy, systemic inflammatory response syndrome (SIRS), and acute kidney injury (AKI). In a study of 312 patients, myoglobin emerged as a notable independent risk factor for these complications, particularly AKI, with a predictive…
A meta-analysis of ten studies involving 1,811 patients found that single-layer pancreaticojejunostomy (PJ) is associated with a significantly reduced rate of clinically relevant postoperative pancreatic fistula (cr-popf) compared to double-layer PJ. The single-layer approach demonstrated a lower grade B popf rate and a consistent trend…
A study involving 788 gallbladder cancer patients identified key predictors of futile up-front surgery, defining futile cases as those resulting in early recurrence or death post-operation. Among patients, 13.6% experienced futile outcomes, with a stark median survival of 6.8 months versus 57.4 months for non-futile…
A significant association was found between behavioral health disorders and new persistent opioid use following major surgeries. Among 62,585 patients studied, 20.3% with behavioral health disorders developed persistent opioid use compared to 16.6% without. This group also required higher median morphine doses. Additionally, those with…
A novel prognostic oxidative stress-immune-inflammation score (posii score) has been developed to enhance survival predictions for gastric cancer patients post-radical gastrectomy. Analysis of 3,612 patients revealed that those in the low posii group exhibited significantly higher 5-year overall and disease-free survival rates, along with reduced…
