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Best Papers in General Surgery
The five that matter, every day.
The hiatal sling liver retraction technique has shown promising results in bariatric and upper gastrointestinal surgeries, significantly reducing liver enzyme elevation compared to the traditional Nathanson retractor. Among 1,874 surgeries, only two cases experienced difficulties, with no liver injuries or adverse effects reported. This technique…
A novel AI-driven system effectively quantifies CD8+ tumor-infiltrating lymphocytes (TILs) in hepatocellular carcinoma (HCC) patients post-liver resection. In a study involving 514 patients, the automated CD8+ TIL scoring system (ATLS-8) revealed five-year overall survival rates of 34.05% for low-score and 65.03% for high-score cohorts. This…
A post-hoc analysis of 588 patients revealed that while robot-assisted pancreatoduodenectomy (rpd) incurs initial higher costs compared to open pancreatoduodenectomy (opd), outcomes improve significantly with experience. Total hospital stay shortened from 12 to 9 days, and costs per rpd procedure decreased from €32,836 to €21,778.…
A study involving 408 patients with gastrointestinal cancers revealed inadequate knowledge, moderate attitudes, and suboptimal practices regarding whole-course management. Mean scores indicated a significant deficit in understanding, with knowledge influencing both attitudes and practices positively. The structural equation model underscored that enhancing knowledge could lead…
A novel laparoscopic technique combining priority dissecting of the inferior mesenteric artery with a complete medial approach significantly improved surgical outcomes for left-sided colon cancer. In a study of 68 matched patients, those using the new method experienced shorter operation times (p=0.032), reduced blood loss…
Transabdominal ultrasonography (TAUS) shows high compatibility with endoscopic retrograde cholangiopancreatography (ERCP) in diagnosing bile duct obstructive lesions. A retrospective study analyzed patient data and found substantial agreement in identifying conditions such as cholangiocarcinoma, bile duct stricture, and pancreatic cancer, with compatibility rates between 71.4% and…
In a study involving 90 patients with periappendiceal abscesses, ultrasound-guided percutaneous catheter drainage (PCD) combined with antibiotics demonstrated significant advantages over emergency laparoscopic surgery (ELS). The PCD approach resulted in shorter operative times, fewer postoperative complications, and reduced hospital stays. These results highlight PCD’s efficacy…
Significant metabolic alterations and the dynamics of GLP-1 and GLP-2 were identified during liver resection in patients, particularly linking these changes to posthepatectomy liver failure (PHLF). Of the patients studied, metabolic clustering showed that 93% of PHLF individuals fell within one cluster. Preoperative GLP-1 levels…
Aptamer-decorated milk-derived nanovesicles (mnvs) effectively targeted cholangiocarcinoma (cca) cells, promoting the delivery of short interfering RNAs (siRNAs) that inhibited key gene expressions. This selective uptake led to reduced tumor growth and increased reactive oxygen species production. Notably, the combined treatment with nanovesicles and chemotherapy showed…
Neoadjuvant therapy changes the prognostic landscape for patients with resected pancreatic ductal adenocarcinoma (PDAC). In a study of 2,760 patients, independent predictors of overall survival (OS) differed significantly: chemotherapy-naïve patients were affected by age, CA19-9 levels, and tumor stage, while neoadjuvant therapy patients faced challenges…
