Triple therapy with folfox-based hepatic arterial infusion chemotherapy, tyrosine kinase inhibitors, and PD-1 inhibitors significantly prolonged overall survival (24.6 vs 11.9 months) and progression-free survival (10.0 vs 7.7 months) compared to dual therapy. The triple-therapy group also had higher response rates and more patients converted to non-high-risk status, showcasing its potential as a first-line treatment […]
Category: General Surgery
Platelet Count and CEA Levels Crucial for predicting Prognosis in Early Colorectal Cancer
Low preoperative platelet count and high serum CEA levels are significant predictors of poor disease-free and overall survival in early colorectal cancer patients (pT2N0M0 or pT3N0M0). Platelet count is a protective factor for disease-free survival, while CEA level is an independent risk factor for overall survival. These easily detectable and patient-acceptable measures could have broader […]
Late Oral Feeding Enhances Nutritional Status Post-Esophagectomy
Patients undergoing late oral feeding post-esophagectomy had significantly less body weight loss, higher calorie and protein intake, and lower malnutrition rates compared to those with early feeding. Complication rates and hospital stays were similar between the groups, indicating that late oral feeding may improve postoperative nutritional status without compromising surgical outcomes. • Why it matters: […]
Improved Surgical Safety Checklist Performance with Simulation Training
OR Black Box technology assessed surgical safety checklist performance during a study comparing in-situ simulation intervention. The simulation group showed improved debrief quality (84% vs. 79%, p
Minimally Invasive vs Open Surgery for Gallbladder Perforations
Among 42 patients with type I gallbladder perforations, 28 underwent laparoscopic cholecystectomy (LC) and 14 had conversion to open cholecystectomy (COC). Significant differences included the location of perforations, with LC more common for fundal perforations, while COC was often required for neck perforations. LC had shorter surgical times and younger surgeons compared to COC. Factors […]
Laparoscopic and Open Pancreaticoduodenectomy Outcomes for Ampullary Cancer
In a comparison of laparoscopic (LPD) versus open (OPD) pancreaticoduodenectomy for ampullary cancer, LPD showed longer operative times but less blood loss and shorter hospital stays. No significant differences were found in morbidity, survival rates, or recurrence-free survival between LPD and OPD. Both approaches had comparable short- and long-term outcomes. Despite fewer lymph nodes harvested […]
New Standardized Reporting of Inguinal Lymph Node Dissection Complications
Experts from various specialties created a standardized system for reporting complications in inguinal lymph node dissection. Using a modified Delphi consensus approach, 47 consultants achieved unanimous agreement on defining and categorizing intraoperative and postoperative complications. The new system classifies postoperative issues into five macrocategories and standardizes reporting for melanoma, penile, and vulval cancer treatments. This […]
Effective Modifiable Risk Reduction in Colorectal Surgery
The DoubleCheck study implemented an enhanced care bundle targeting modifiable risk factors during colorectal surgery, resulting in a significant reduction in colorectal anastomotic leakage (CAL) compared to historical controls. Patients in the intervention group experienced fewer intraoperative risk factors and a lower incidence of CAL (6.2% vs. 8.6%, p=0.039). Multivariate analysis confirmed the bundle’s effectiveness […]
Effect of Home Residency Programs on Surgical Match Rates
Students from institutions with home surgical residency programs were 1.76 times more likely to match into surgical specialties compared to those without, resulting in 39.1% match rate for the former and 22.3% for the latter. Additionally, students with home programs were more likely to match into academic residencies. Future studies should investigate how resources impact […]
Robotic Warshaw Procedure Reduces Splenic Infarction Risk
Robotic warshaw procedure (r-wp) demonstrated superiority over laparoscopic (l-wp) in reducing postoperative splenic infarction incidence, despite longer operative times. Among 33 cases analyzed, r-wp completed procedures laparoscopically, while l-wp required open conversion in 8.7% cases. Although r-wp showed prolonged surgery duration (421 vs. 300 min), blood loss was comparable (19 vs. 20 ml). Notably, l-wp […]