A study evaluated the feasibility of EUS-guided fine-needle biopsy (EUS-FNB) for next-generation sequencing (NGS) in unresectable pancreatic ductal adenocarcinoma (PDAC). The technical yield of EUS-FNB met criteria in 48% of cases, while the molecular yield was remarkably high at 98%. This means that nearly all qualifying biopsies provided sufficient DNA for mutation detection. Most frequently […]
Category: Surgical Endoscopy
EUS-BD offers reduced pancreatitis risk compared to ERCP
A systematic review and meta-analysis revealed that endoscopic ultrasound-guided biliary drainage (EUS-BD) is a safe alternative to ERCP transpapillary drainage (ERCP-TPD) for primary biliary drainage in patients with distal malignant biliary obstruction (DMBO). Among 815 patients analyzed, clinical and technical success rates were similar for both techniques. However, EUS-BD showed a significant reduction in post-procedure […]
Radiation-emitting stents improve survival in cholangiocarcinoma patients
In a multicenter trial, the use of radiation-emitting metallic stents (REMS) combined with hepatic arterial infusion chemotherapy (HAIC) significantly enhanced overall survival (10.2 months vs. 6.7 months) and time to symptomatic progression (8.6 months vs. 5.4 months) compared to self-expandable metallic stents (SEMS) with HAIC in patients with unresectable Bismuth type III or IV perihilar […]
Narrow band imaging enhances early detection of gastrointestinal lesions
Narrow band imaging-magnifying endoscopy (NBI-ME) demonstrates high sensitivity and specificity for diagnosing gastrointestinal neoplastic lesions. In a study of 1623 patients, NBI-ME achieved an overall sensitivity of 96.2% and specificity of 91.0%. It effectively detected conditions such as Barrett’s esophagus and various gastric lesions, facilitating targeted biopsies and leading to timely interventions in patients with […]
Robotic-assisted one-stage management improves outcomes for choledocholithiasis
A recent study highlighted that robotic-assisted laparoscopic cholecystectomy with transcystic common bile duct exploration enables quicker duct clearance and shorter hospital stays. Patients undergoing this one-stage approach experienced significantly lower times for CBD clearance (45.2 hours vs. 47.0 hours), reduced length of stay (3.9 days vs. 5.1 days), and lowered radiation exposure (23.0 mSv vs. […]
TIF 2.0 demonstrates high success rates for GERD treatment
A prospective multicenter study tracked outcomes in patients with GERD after transoral incisionless fundoplication (TIF 2.0). Clinical success was achieved in 94% of participants, with improvements in GERD-specific health scores for 89% and a normalization of elevated reflux symptom index (RSI) in 85%. Patient satisfaction surged from 8% to 79%, and 80% of patients required […]
Wide hot snare polypectomy outperforms other methods for small tumors
In a study assessing salvage treatments for rectal neuroendocrine tumors (RNETs) under 10 mm, wide hot snare polypectomy (WHSP) showed superior outcomes. Of 121 patients analyzed, WHSP achieved an impressive 72.7% R0 resection rate compared to other methods. With a focus on effectiveness and safety, WHSP emerged as a rapid and straightforward approach for these […]
Higher lower esophageal sphincter pressure predicts better outcomes after POEM
In a study involving 237 patients undergoing per oral endoscopic myotomy (POEM), researchers found that while achalasia type was not predictive of the need for further interventions or symptom relief, a higher integrated relaxation pressure (IRP) on preoperative manometry was associated with greater postoperative symptom improvement, indicated by reduced Eckardt scores (p=0.03). This suggests that […]
Flexible endoscopic treatment for Zenker’s diverticulum proves effective
A multicenter study involving 327 patients demonstrated that flexible endoscopic treatment for Zenker’s diverticulum exhibits high success rates, achieving technical success of 99.2% and clinical success of 97.4%. While the rates of adverse events and re-admissions were reported at 11.2% and 16.7%, respectively, the mortality rate remained low at 0.3%. Importantly, the study found no […]
EUS-CDS with LAMS shows superior success for DMBO treatment
A comparative network meta-analysis revealed that EUS-CDS with lumen-apposing metal stents (LAMS) outperformed other drainage techniques for distal malignant biliary obstruction (DMBO). This method yielded the highest technical and clinical success rates, particularly after comparing with ERCP and EUS-CDS with self-expandable metal stents. Notably, the study recommends discontinuing percutaneous transhepatic biliary drainage (PTBD) as a […]