Analysis of 120 gastrectomies for appendiceal pseudomyxoma peritonei (PMP) over 20 years revealed a median survival of 104 months and a 10-year overall survival rate of 47%. While complications were observed in 32% of cases, 90-day mortality was low at 1.75%. Outcomes improved over decades, with 82.2% achieving complete cytoreduction (CCR) in the later period, […]
Category: Upper Gastrointestinal Tract
Interval conservative management is safe for incarcerated paraesophageal hernias.
Adopting an initial conservative management strategy for clinically stable patients with incarcerated paraesophageal hernias allows 66% to resolve their conditions without urgent surgery. Among the 35 patients studied, one experienced unplanned readmission before planned interval repair. Complication rates remained similar between those who underwent conservative management and those requiring surgery. Overall, managing these patients conservatively […]
Total Mesogastric Excision Shows Promising Short-Term Outcomes
A study examining total mesogastric excision (TME) for gastric cancer found that it results in significantly lower mean blood loss and a higher number of metastatic lymph nodes compared to standard D2 lymphadenectomy. With 37 patients involved, initial findings suggest TME offers advantages in peroperative and short-term outcomes, potentially improving disease-free survival. Conducted in Istanbul, […]
Neoadjuvant treatment improves survival in esophageal cancer patients
A retrospective analysis involving 645 patients with cT2 staged adenocarcinomas indicated that neoadjuvant treatment followed by surgery (nat/s) yields significantly better overall survival compared to primary surgery (ps). Median overall survival was 114.0 months for nat/s versus 51.0 months for ps in the cT2cnany cohort. Additionally, nat/s was associated with improved disease-free survival in cT2cn0 […]
High 30-Day Morbidity and Mortality Rates for PPU Surgery
In an international cohort study of 1,874 patients with perforated peptic ulcer (PPU), researchers found a 30-day morbidity rate of 48.5% and a mortality rate of 9.3%. Key factors affecting these rates included age over 50, female gender, shock on admission, and acute kidney injury, all significantly associated with increased morbidity and mortality. Delayed presentation […]
Fundoplication leads to fewer complications than gastric fixation.
A retrospective cohort study analyzing 1,317 emergency hiatal hernia repairs revealed that fundoplication significantly reduced 30-day complication (odds ratio [OR] 0.53, p < 0.001) and mortality rates (OR 0.55, p = 0.033) compared to gastric fixation. No significant differences were found regarding 30-day readmission (OR 0.86, p = 0.449) or reoperation rates (OR 0.66, p […]
Nomogram effectively predicts overall survival for gastric cancer patients.
The study developed a prognostic nomogram for gastric cancer patients post-neoadjuvant chemotherapy and radical surgery, revealing promising results. The median progression-free survival was 43.8 months, and overall survival reached 61.2 months. The nomogram demonstrated excellent discrimination with a c-index of 0.689 and area under the curve (AUC) values of 0.778, 0.746, and 0.725 for 3-, […]
Early detection of infectious complications post-gastric cancer surgery
Elevated interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in serum and drainage fluid indicate infectious complications following minimally invasive gastric cancer surgery. Among 205 patients, pod 1 serum IL-6 levels above 47 pg/ml exhibited 74.1% sensitivity, while drainage fluid IL-6 levels over 14,750 pg/ml demonstrated 100% sensitivity for intra-abdominal abscess detection. These findings suggest […]
Causal relationships exist between biliary disorders and GERD.
Significant causal effects of genetically predicted cholelithiasis, cholecystitis, and cholecystectomy on gastroesophageal reflux disease (GERD) were identified, with odds ratios of 1.04, 1.06, and 2.56, respectively. Additionally, the study confirmed a bidirectional relationship, where GERD also influences the likelihood of developing cholelithiasis and cholecystitis. Mediation analyses showed that both biliary disorders and GERD partially mediate […]
Neoadjuvant chemotherapy significantly improves survival in gastric cancer.
Findings indicate that neoadjuvant chemotherapy (ctx) for resectable gastric cancer results in significantly longer overall survival (OS) compared to neoadjuvant chemoradiation (crtx). Analysis of 14,266 patients revealed a 20%-30% improvement in 5-year OS for the ctx group, despite a higher prevalence of complete pathological response in the crtx cohort. The study posits that current AJCC […]