Analyzing 1020 patients with gastric signet-ring cell cancer (GSRCC), researchers investigated the relationship between the number of examined lymph nodes (ELNs) and prognosis. X-tile analysis determined the optimal ELN cutoff as 22. Patients with more than 22 ELNs demonstrated higher 5-year overall survival (66.9% vs. 74.9%). Multivariate analyses revealed that a higher number of ELNs […]

Examining 115 elderly esophageal cancer patients, researchers assessed preoperative sarcopenia comprehensively using skeletal mass index, handgrip strength, and gait speed. Sarcopenia, identified in 20% of patients, correlated with older age and advanced cancer stage. Although postoperative complications showed no significant difference, slow gait speed was associated with more severe complications. The sarcopenia group exhibited significantly […]

A cohort study involving 205 gastric adenocarcinoma patients treated with neoadjuvant chemotherapy aimed to improve prognosis prediction. The developed radiomic model, incorporating pre- and post-treatment features, outperformed pathological T stage models. The final radiomic model, integrating radiomic and clinicopathological data, demonstrated superior accuracy in predicting 3-year survival. Results suggest the radiomic model could serve as […]

Analyzing data from the Logica randomized controlled trial (RCT) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA), researchers explored the influence of the Logica RCT on laparoscopic gastrectomy practice in the Netherlands (2012-2021). While the Logica RCT showed no significant impact on outcomes, the DUCA nationally revealed a shift, indicating laparoscopic gastrectomy’s benefits, significantly reducing […]

Examining elderly gastric cancer patients (>75 years) in the U.S., this study, using propensity score matching, reveals that neoadjuvant chemotherapy (NAC) utilization increased from 2013 to 2019 (21% to 42.7%). After matching, 1958 patients showed that those receiving NAC experienced enhanced oncological outcomes following resection for locally advanced gastric cancer. The findings advocate for the […]

Examining esophagectomy outcomes for pathologic T3 esophageal cancer (n=519, 2000–2019), researchers categorized patients based on circumferential radial margin (CRM) involvement. CRM+ (tumor at CRM) correlated with shorter disease-free survival (DFS) and overall survival (OS) compared to CRM-. CRM-close (tumor >0 to 1 mm from CRM) showed similar outcomes to CRM-. After adjustments, College of American […]

A European multicenter study comparing total (TG) and subtotal gastrectomy (SG) for antropyloric poorly cohesive carcinoma found no significant difference in 5-year overall survival (TG: 53.8%, SG: 53.0%) or disease-free survival (TG: 46.0%, SG: 45.3%). Despite similar baseline characteristics, TG showed higher postoperative complications. This study supports subtotal gastrectomy as a viable option, offering comparable […]

Analyzing 34 cases with right aortic arch (RAA) or double aortic arch (DAA) and esophageal cancer, the study found that esophagectomy, whether via thoracotomy or thoracoscopic surgery, can be safely performed for both conditions. Patients, predominantly Japanese males with squamous cell carcinoma, commonly underwent left thoracotomy for RAA and showed similar left and right approaches […]

Examining 2013 publications, researchers spotlight the surge in gastric cancer immunotherapy research, with China dominating contributions. Keywords like “tumor microenvironment” and “adoptive immunotherapy” emerged as hotspots. Analysis of clinical trials underscores progress, emphasizing immune checkpoint inhibitors and chimeric antigen receptor T-cells as promising options. The study calls for future research fusing immunotherapies with conventional treatments, […]