Minimally invasive, ultrasound-guided robotic resections for gastric gastrointestinal stromal tumors (GISTs) demonstrate remarkable safety and efficacy. A study of 46 patients, primarily with challenging tumor locations, revealed no intraoperative complications or conversions to open surgery. The approach resulted in less than 5% postoperative morbidity and an impressive median disease-free survival rate of 98% at 36 […]
Category: Upper Gastrointestinal Tract
RefluxStop surgery shows significant long-term effectiveness in GERD treatment
In a multicenter trial involving 50 adults with chronic gastroesophageal reflux disease (GERD), RefluxStop surgery demonstrated remarkable long-term outcomes over five years. The median GERD-Health-Related Quality of Life (GERD-HRQL) score improved by 90%, and 24-hour pH monitoring revealed a 90% reduction in acid exposure time. Notably, only one participant continued proton pump inhibitors at follow-up, […]
Endoscopic submucosal dissection outperforms endoscopic mucosal resection
Researchers found that endoscopic submucosal dissection (ESD) offers superior clinical outcomes for early oesophageal cancer compared to endoscopic mucosal resection (EMR). ESD demonstrated a shorter hospitalization time (7.51 vs. 9.16 days) and a significantly better postoperative quality of life. Although ESD surgeries took longer, both techniques achieved comparable resection rates. Importantly, ESD resulted in fewer […]
High-Volume Centers Offer Better Long-Term Survival for Esophageal Cancer Surgery
Patients undergoing esophagectomy for cancer at high-volume centers exhibit improved long-term survival, as shown in a meta-analysis involving 23,194 individuals. Those treated in these centers lived an average of 4.3 months longer compared to their counterparts in low-volume centers. The analysis also indicated a significantly reduced risk of mortality over a 60-month follow-up period. This […]
Predictive model enhances surgical planning for advanced gastric cancer
A new predictive model developed for assessing surgical difficulty in distal gastrectomy for advanced gastric carcinoma shows promise. An analysis of 520 patients revealed seven independent risk factors, including BMI and tumor size. The model achieved an impressive area under the curve (AUC) of 0.787, indicating strong predictive accuracy. This tool aims to aid surgeons […]
New nomogram predicts survival for signet ring cell gastric cancer patients
A novel prognostic nomogram has been developed for predicting overall survival (OS) and cancer-specific survival (CSS) in signet ring cell gastric cancer patients post-surgery. Analyzing data from 3,481 patients, researchers identified critical independent prognostic factors, including race, chemotherapy, and lymph node ratio. The nomogram demonstrated impressive accuracy with a c-index of 0.748 for OS and […]
Pathological complete response enhances survival in esophageal cancer.
A recent meta-analysis indicates that pathological complete response (pCR) following neoadjuvant chemoradiotherapy significantly improves long-term survival outcomes in patients with locally advanced esophageal cancer undergoing surgery. Findings from 38 included studies revealed a hazard ratio of 0.54 for overall survival and 0.51 for disease-free survival among those achieving pCR. Subgroup analyses showed even greater benefits […]
Nomogram effectively predicts anastomotic leakage in elderly patients.
A LASSO-based nomogram has been developed to predict anastomotic leakage (AL) in elderly patients undergoing laparoscopic gastrectomy. An analysis of 884 patients identified significant predictors, including age, ASA score, diabetes, intraoperative blood loss, and prognostic nutritional index. The nomogram demonstrated high predictive accuracy, achieving AUC values of 0.870 and 0.890 in training and validation cohorts, […]
Cryopreserved fibroblast sheets reduce esophageal leakage risk
Cryopreserved allogeneic multilayered fibroblast sheets demonstrated efficacy in preventing esophageal anastomotic leakage in a rat model. The incidence of leakage was significantly lower in the fibroblast sheets group (28%) compared to controls (61%; p = .02). Additionally, the burst pressure was notably higher in the sheet group (124 ± 30 mm Hg) versus controls (78 […]
Effective Management Strategies for Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) poses challenges with its typical and atypical presentations requiring careful diagnosis. Key diagnostic tools like endoscopy, manometry, and reflux monitoring are essential for confirming GERD and tailoring treatment. Management varies from lifestyle modifications to pharmacologic therapies, with surgical options available for persistent cases. Effective treatment can significantly improve prognosis and quality […]