Wound irrigation with polyhexanide solution did not significantly decrease the incidence of surgical site infections compared to saline or no irrigation after laparotomies. The study, involving 689 patients, found an overall infection rate of 11.8%, with no statistically significant difference between the groups. Further research is needed to assess the potential benefits in contaminated and […]
Category: Wounds
Risk factors for anastomotic dehiscence in patients receiving negative pressure wound therapy after intestinal anastomosis.
The use of negative pressure wound therapy (NPWT) during intestinal anastomosis has been controversial. A single-center cohort study was conducted to identify risk factors for anastomotic dehiscence in patients who received NPWT therapy. The study found that females, delayed fascial closure, use of vasopressors, and NPWT pressures >110 mmHg were associated with a higher risk […]
Non-Thermal Plasma accelerates wound healing in abdominal surgeries
Non-Thermal Plasma (NTP) therapy was evaluated as a method to speed up wound healing in patients who underwent laparoscopic and open abdominal surgeries. Researchers used a needle-type reactor with an irradiance of 0.5 w/cm² to apply NTP. The pilot study showed promising results, indicating that NTP therapy can be efficacious and safe in enhancing recovery […]
Customized bacteriophage therapy effectively cures chronic wounds and promotes healing
A randomized, placebo-controlled, double-blind clinical trial evaluated the efficacy and safety of bacteriophage therapy for chronic wounds. Customized bacteriophage cocktails were applied to wounds, resulting in 93.3% becoming sterile in 39 days, followed by complete healing within 90 days. In contrast, 83.3% of wounds treated with placebo remained colonized by bacteria without healing. The study […]
Weight Loss, Not BMI Alone, Predicts Wound Complication Risk in Obese Hernia Patients
A retrospective study analyzed 182 obese patients who underwent open transversus abdominis release (TAR) for complex ventral hernias. Among these patients, those with a BMI greater than 40 did not show significant differences in surgical site occurrences and infections compared to those with a lower BMI. However, patients who achieved at least a 3% preoperative […]
Sterile Gloves Are Not Superior to Nonsterile Gloves for Wound and Laceration Repair
This systematic review and meta-analysis compared the use of sterile and nonsterile gloves for wound and laceration repair. The analysis found no significant difference in the rates of infection or wound healing between the two types of gloves. These results suggest that nonsterile gloves are equally effective in preventing complications during wound and laceration repair, […]
Aqueous Povidone-Iodine Irrigation Does Not Reduce Surgical Site Infection Incidence Compared to Saline Irrigation
Researchers conducted a randomized controlled trial to compare the effectiveness of intraoperative wound irrigation with aqueous povidone-iodine (PVP-I) versus saline in reducing surgical site infections (SSI) in clean-contaminated wounds after gastroenterological surgery. The study included 941 patients and found that the incidence of incisional SSI was slightly higher in the group receiving PVP-I (7.6%) compared […]
Global Telemedicine for Surgical Wound Assessment: Lower SSIs Found in International Cohort and Meta-analysis
Using telemedicine for remote wound reviews can be upscaled globally and may help reduce the risk of SSI after surgery. In an international cohort study of over 15,000 patients from 66 countries, telemedicine follow-up resulted in slightly lower SSI rates compared to in-person review. This association persisted after risk adjustment and was consistent across sensitivity […]
Decoding Aberrant Scarring: Unraveling Mechanisms and Implications
Skin wound healing often leads to abnormal scarring, such as keloids or hypertrophic scars, impacting millions globally. While the precise mechanisms remain elusive, evidence suggests ongoing inflammation in susceptible individuals perpetuates extracellular matrix changes, resulting in fibrotic lesions. Abnormal scarring, causing pain, functional impairment, and aesthetic concerns, lacks effective treatment. The study underscores the urgent […]
Prophylactic Negative Pressure Wound Therapy in Emergency Laparotomy: No Significant Reduction in Surgical Site Infections
Examining 65,803 emergency laparotomy patients, researchers found no significant difference in surgical site infection (SSI) rates when comparing prophylactic negative pressure wound therapy (NPWT) to standard dressings. Propensity-matched cohorts with completely or partially closed incisions showed similar SSI rates (13.4% vs. 11.9% and 3.6% vs. 4.4%, respectively). Secondary outcomes, including postoperative complications and hospital length […]