Skin wound healing often leads to abnormal scarring, such as keloids or hypertrophic scars, impacting millions globally. While the precise mechanisms remain elusive, evidence suggests ongoing inflammation in susceptible individuals perpetuates extracellular matrix changes, resulting in fibrotic lesions. Abnormal scarring, causing pain, functional impairment, and aesthetic concerns, lacks effective treatment. The study underscores the urgent […]
Category: Wounds
Prophylactic Negative Pressure Wound Therapy in Emergency Laparotomy: No Significant Reduction in Surgical Site Infections
Examining 65,803 emergency laparotomy patients, researchers found no significant difference in surgical site infection (SSI) rates when comparing prophylactic negative pressure wound therapy (NPWT) to standard dressings. Propensity-matched cohorts with completely or partially closed incisions showed similar SSI rates (13.4% vs. 11.9% and 3.6% vs. 4.4%, respectively). Secondary outcomes, including postoperative complications and hospital length […]
Boosting Wound Healing: Unleashing the Power of Mesenchymal Stem Cells with Combo Therapy
Researchers explore the evolving landscape of mesenchymal stem cell (MSC) therapy in wound healing. While MSCs show promise in tissue repair, their full potential is hindered. The study advocates for combination therapies, citing enhanced efficacy through biomaterials, platelet-rich plasma (PRP), and stress-response manipulation. By synergizing MSCs with strategic approaches, the review illuminates a path toward […]
Single-Use Negative Pressure Wound Therapy Reduces Surgical Site Infections
Analyzing 19 studies, researchers reviewed whether single-use negative pressure wound therapy (sNPWT) could diminish surgical site infections (SSIs) in at-risk patients with closed surgical incisions. The meta-analysis indicated a significant reduction in composite, superficial, and deep SSIs with sNPWT compared to standard care across diverse surgical specialties. The -80 mmHg sNPWT device emerged as an […]
Mapping Review Reveals Strategies for Reducing Pain in Chronic Wound Dressing Changes
This mapping review addresses a pressing issue: pain during chronic wound dressing changes. Existing UK guidelines prioritize wound healing over pain management during these procedures. The review aims to gather, assess, and describe current research on strategies for assessing and reducing pain during chronic wound dressing changes. By sifting through the available evidence, it seeks […]