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Combined surgery and endoscopic therapy shows high success in Crohn’s strictures

A novel approach using combined surgery and endoscopic stricturotomy achieved a remarkable 100% immediate success rate in treating multi-segmental fibrotic strictures from Crohn’s disease. Among 21 patients, 85.7% experienced significant symptom relief, and 90.5% returned to a regular diet within eight weeks. With a median follow-up of 528 days, the one-year re-intervention rate stood at 81.7%. Although adverse events occurred in 19% of cases, they were manageable intraoperatively without further intervention.

Journal Article by Peng B, Liu Z (…) Guo Q et 2 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Opioid prescriptions can be safely omitted after major surgery.

A prospective study assessed opioid prescription necessity post-major intra-abdominal surgery. Among 333 patients, only 17% of those in the intervention group received opioids within 30 days, compared to 46% in the control group (p <.001). While inpatient opioid usage was similar across both groups, the median morphine milligram equivalents prescribed at discharge was significantly higher in the control group. Importantly, thirty-day readmission rates remained comparable, suggesting opioid omission does not disrupt recovery.

Journal Article by Ottaviano KE, Mian BM (…) Chismark AD et 5 al. in J Gastrointest Surg

Copyright © 2025. Published by Elsevier Inc.

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ω-3 fish oil emulsion significantly reduces gastric emptying delays

A retrospective cohort study involving 210 patients revealed that perioperative ω-3 fish oil fat emulsion notably lowers the incidence of delayed gastric emptying (DGE) following Roux-en-Y reconstruction for gastric cancer, with rates dropping from 15.5% to 4.3% in the intervention group. Additionally, the ω-3 group benefited from a reduced median hospital stay of 10 days compared to 13 days in controls, demonstrating ω-3 supplementation as an independent protective factor against DGE and improving recovery.

Journal Article by Jing S, Chen H (…) Wang M et 6 al. in J Gastrointest Surg

Copyright © 2025 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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Synchronous portal vein embolization improves outcomes in liver surgery

In a cohort study of 115 patients with hepatitis B virus-related hepatocellular carcinoma, synchronous terminal branches portal vein embolization (tbpve) combined with transcatheter arterial chemoembolization (tace) resulted in significantly greater future liver remnant volume and hypertrophy compared to traditional portal vein embolization (pve). Those receiving tbpve demonstrated improved perioperative metrics and better disease-free survival rates post-major hepatectomy. The study highlights tbpve’s efficacy in enhancing surgical resectability for previously unresectable cases.

Journal Article by Liu W, Tao H (…) Fang C et 3 al. in J Gastrointest Surg

Copyright © 2025. Published by Elsevier Inc.

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Advanced technologies enhance personalized medicine in gastrointestinal oncology

Advances in AI, multi-omic profiling, and imaging technologies significantly improve personalized medicine in gastrointestinal surgical oncology. These innovations lead to better patient stratification and tailored therapies, enhancing clinical outcomes. However, challenges such as data integration, patient privacy, and predictive model validation remain. To overcome these issues, researchers emphasize the need for standardized data interoperability and advanced security methods, alongside promoting transparency through explainable AI to build trust among clinicians and patients.

Review by Kim DH in J Pers Med

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Guidance aids decision-making for managing colorectal polyps

Guidelines developed by the BSG/ACPGBI assist clinicians in managing colorectal polyps for patients with a life expectancy of under 10 years. The guidance outlines 33 recommendations drawn from a consensus process involving 28 experts. It includes assessments of life expectancy, polyp characteristics, and risks of polypectomy versus conservative management. A comparative model has been established to help weigh the risks of malignancy against potential complications, allowing for personalized decision-making between clinicians and patients.

Journal Article by Rutter MD, Ranjan R (…) Sharp L et 26 al. in Gut

© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.

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EMR shows lower mortality and healthcare utilization than surgery

In a comparative study of colon adenomas and early-stage cancers, endoscopic mucosal resection (EMR) significantly outperformed traditional surgery. Among 568 EMR patients and 2,054 surgical patients, EMR was associated with a lower all-cause mortality rate (hazard ratio 0.31) and reduced healthcare utilization over an average follow-up of 4.5 years. These findings suggest EMR is a favorable treatment option for eligible lesions in community-based settings.

Journal Article by Kwok K, Chao C (…) Wu B et 5 al. in Gastrointest Endosc

Copyright © 2025 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

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Predictive model for liver metastasis risk in AEG patients

A novel nomogram accurately predicts the risk of postoperative liver metastasis in patients with adenocarcinoma of the esophagogastric junction (AEG) based on six independent factors: type of surgery, N stage, tumor differentiation, vascular thrombus, intestinal type, and p53 status. High predictive accuracy was demonstrated with a concordance index exceeding 0.96 in both training and validation cohorts, supporting enhanced risk assessment and individualized treatment strategies to improve clinical outcomes post-surgery.

Journal Article by Deng L, Sun J (…) Li B et 2 al. in BMC Gastroenterol

© 2025. The Author(s).

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Key predictors identified for laparoscopic appendectomy conversion

A systematic review of 45 studies with over 3.2 million cases revealed an 8.7% conversion rate from laparoscopic to open appendectomy. Key risk factors included older age, male gender, and comorbidities such as obesity and diabetes. Other significant predictors were previous abdominal surgery, prolonged symptom duration, and elevated inflammatory markers. This research serves as a guide for surgeons to better assess patient risks preoperatively, thereby enhancing surgical outcomes despite an overall moderate evidence quality.

Journal Article by Mirdamadi A, Javid M (…) Hassanipour S et 10 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Fully-covered metal stents outperform plastic for biliary drainage

A comprehensive review of 81 studies with 26,251 patients reveals that fully-covered self-expandable metal stents used during endoscopic retrograde cholangiopancreatography result in fewer adverse events compared to plastic stents, though they carry a higher risk of pancreatitis. Plastic stents resulted in more complications and shorter duration of effectiveness. Internal stents are identified as the best option for patients with perihilar obstruction, highlighting significant variances in efficacy and safety across preoperative biliary drainage methods.

Journal Article by Sun P, Zhong Y (…) Hu H et 9 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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