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Serum EV-MDM2 Levels May Indicate Liposarcoma Recurrence

Elevated levels of extracellular vesicle (EV) MDM2-DNA in retroperitoneal liposarcoma patients suggest this biomarker could identify disease recurrence. In a study involving 42 patients, EV-MDM2 levels were significantly higher in individuals with well-differentiated or dedifferentiated liposarcoma compared to healthy controls. Post-surgery, levels dropped but rose again during follow-up for some, aligning with imaging evidence of disease recurrence. These findings indicate EV-MDM2’s potential in guiding early surveillance and treatment decisions for liposarcoma.

Journal Article by Calore F, Casadei L (…) Grignol VP et 9 al. in Ann Surg

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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Diffusion-Weighted MRI Detects More Occult Liver Metastases

In a pilot study involving 38 patients with high-risk pancreatic adenocarcinoma, diffusion-weighted MRI revealed occult liver metastases in 34.2% of cases, significantly higher than peritoneal metastases at 5.3%. With a sensitivity of 86.7% for liver metastases, it allowed avoidance of unnecessary surgical explorations in nearly 40% of patients. Ultimately, intraoperative findings revealed additional metastases in some cases, emphasizing the potential impact of DWI-MRI on surgical planning and patient outcomes.

Journal Article by Charbonneau J, Noël P (…) Brind’Amour A et 5 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Seventeen lymph nodes optimally predict survival in mucinous adenocarcinoma

A multicenter study analyzed lymph node evaluations in colorectal mucinous adenocarcinoma (MAC) and established that examining at least 17 lymph nodes (ELNs) significantly correlates with improved survival rates. Data from Chinese and SEER cohorts showed a consistent median ELN count of 17, with higher counts reducing mortality risks for MAC patients. This finding challenges the current standard of 12 ELNs, suggesting a need for revised evaluation protocols to enhance prognostic outcomes in MAC surgeries.

Journal Article by Yin Q, Sun Y (…) Yang H et 25 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Predictive Model Enhances Surgical Decision-Making for Pancreatic Tumours

A study evaluating tumour pseudocapsule status using CT-based radiomics found that patients with a complete pseudocapsule showed significantly better recurrence-free survival rates than those with an incomplete pseudocapsule. Specifically, 3- and 5-year survival rates were 94.8% and 92.5% for the complete group compared to 76.7% and 70.4% for the incomplete group. This radiomics-predictive model effectively identifies pseudocapsule status, suggesting that enucleation may be more beneficial for patients with intact pseudocapsules.

Journal Article by Wang Y, Gu W (…) Ji S et 10 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Treatment adjustments significantly enhance endoscopic prognosis in Crohn’s disease

In a cohort of 199 Crohn’s disease patients with postoperative anastomotic lesions, treatment adjustments yielded notable improvements in endoscopic outcomes. Specifically, strategies such as biologics switching and biologic optimization led to marked mucosal healing and ulcer improvement. Switching from non-biologics to biologics resulted in superior endoscopic results, while optimization of biologics enhanced outcomes for patients with low trough levels. Overall, these findings emphasize the effectiveness of tailored treatment adjustments in improving patient prognosis.

Journal Article by Yin L, Ding C (…) Gong J et 6 al. in Clin Transl Gastroenterol

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.

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Small bites technique improves postoperative outcomes in laparotomies

A systematic review and meta-analysis of seven randomized controlled trials involving 2,299 patients highlighted that the small bites technique for midline abdominal incision closure significantly reduced the incidence of ventral incisional hernia (RR: 0.46, p < 0.01) and surgical site infection (RR: 0.73, p < 0.01) compared to large bites. Additionally, patients experienced a shorter hospital stay (MD: -1.03 days, p < 0.01) without an increase in overall mortality rates, indicating superior postoperative recovery.

Journal Article by Alrashidi A, Hageen AW (…) Elmahi M et 10 al. in World J Surg

© 2025 International Society of Surgery/Société Internationale de Chirurgie (ISS/SIC).

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CALLY Index effectively predicts intestinal ischemia in hernias

The study demonstrates that the CALLY Index and modified Glasgow Prognostic Score (MGPS) serve as significant predictors for intestinal ischemia in patients with strangulated abdominal wall hernias. Among 125 patients analyzed, a CALLY score below 2.5 was independently associated with higher ischemia risk. Receiver operating characteristic (ROC) analysis revealed strong predictive power for this cutoff, indicating its potential role in enhancing early detection and guiding timely surgical intervention, crucial for improving patient outcomes.

Journal Article by Angın YS, Şendil AM (…) Ulaş M et 3 al. in Hernia

© 2025. The Author(s).

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Four distinct trajectories of postoperative recovery identified.

The study identified four postoperative quality of recovery (QoR) trajectories among 206 esophagectomy patients: poor QoR (18.4%), poor to moderate QoR (40.3%), moderate to good QoR (24.8%), and good QoR (16.5%). Key predictors of poor QoR included preoperative nutritional risk, lower QoR-15 scores, longer surgical duration, and higher postoperative pain scores during coughing. These findings emphasize the necessity for targeted interventions to enhance postoperative recovery outcomes.

Journal Article by Yin F, Li LT (…) Yu H et 2 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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High postoperative complications and mortality remain in gastric volvulus surgeries.

A systematic review analyzed surgical outcomes for acute gastric volvulus due to large paraesophageal hernias, involving 15,178 patients across 171 studies. Despite advancements, 32% faced postoperative complications, 7.6% required reinterventions, and 30-day mortality reached 5.7%. The average hospital stay was 7.9 days. These concerning results underscore the need for early diagnosis and timely surgical intervention to enhance outcomes in affected patients, particularly given their average age of 75 years.

Review by Manterola C, Biel E (…) Grande L et 2 al. in World J Emerg Surg

© 2025. The Author(s).

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Key risk factors for bowel resection identified in hernia patients

A study of 652 patients undergoing emergency surgery for acute irreducible inguinal hernias revealed that 15% required bowel resection. Key preoperative risk factors for resection included femoral hernia and intestinal obstruction, with additional factors like female gender, older age, and comorbidities increasing likelihood of surgery. Patients needing resection had heightened post-operative complications and longer hospitalizations. Integrating these findings into clinical decision-making may enhance patient management and outcomes.

Journal Article by Rodrigues-Gonçalves V, Verdaguer-Tremolosa M (…) López-Cano M et 3 al. in Cir Esp (Engl Ed)

Copyright © 2025. Published by Elsevier España, S.L.U.

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