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New Amylase Metric Predicts Pancreatic Fistulas Better

The “real amylase value” (RAV) significantly outperforms traditional drain amylase concentration in predicting postoperative pancreatic fistula (POPF) risk. An analysis of 198 patients revealed RAV’s area under the ROC curve reached 0.85 on postoperative day 1 and 0.89 on day 3, compared to 0.79 for classic measurement. Enhanced prediction lets surgeons optimize clinical management, refine drain removal timing, and target intervention strategies for high-risk patients, potentially improving recovery outcomes.

Journal Article by Emral AC, Çetinkaya G, Dikmen K and Kerem M in ANZ J Surg

© 2025 The Author(s). ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.

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Radiomics Models Predict Complications in Hepatocellular Carcinoma

New radiomic prediction models effectively identify post-hepatectomy complications and early recurrences in hepatocellular carcinoma patients. Utilizing features from two-dimensional shear wave elastography, the comprehensive complication index (CCI) model achieved an AUC of 0.896, while the recurrence model reached 0.854. Key predictors included radiomic signatures, platelet count, age, and blood flow. These advancements enable targeted interventions for high-risk individuals at a crucial postoperative stage, enhancing patient outcomes.

Observational Study by Jiang D, Ren J (…) Li Y et 8 al. in Eur J Med Res

© 2025. The Author(s).

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Surgery for Benign Polyps Often Causes Unnecessary Harm

Surgical treatment of complex benign colonic polyps significantly increases the risk of adverse events compared to endoscopy. An analysis of 240 patients revealed surgeries were linked to a higher likelihood of complications (odds ratio 3.27), severe adverse events (OR 7.5), and reinterventions (OR 25.6). Average hospital stays extended to 10 days for surgical patients, while endoscopic patients had no stay. These findings underscore the urgent need for improved referral pathways to prioritize less invasive treatments.

Journal Article by Sala-Miquel N, Medina-Prado L (…) Jover R et 11 al. in Therap Adv Gastroenterol

© The Author(s), 2025.
© The Author(s), 2025.

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ERCP Triumphs in Treating Severe Acute Cholangitis

Endoscopic retrograde cholangiopancreatography (ERCP) outperformed percutaneous transhepatic biliary drainage (PTBD) in patients with severe acute cholangitis due to common bile duct stones. ERCP achieved definitive stone clearance in 92.1% of cases and enabled shorter hospital stays, with faster ambulation and reduced patient discomfort. Although both methods effectively lowered inflammation and pain, PTBD patients experienced significantly higher discomfort from drainage. The overall complication rates were comparable, underscoring ERCP as the superior single-stage treatment.

Journal Article by Yang Y, Wang Y (…) Zhu L et 2 al. in Updates Surg

© 2025. Italian Society of Surgery (SIC).

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National Barrett’s Registry Boosts Early Detection of Esophageal Cancer

A structured Barrett’s program has empowered early diagnosis and treatment of esophageal adenocarcinoma (EAC), revealing a 4.7% incidence rate of high-grade dysplasia (HGD) and EAC among patients. Over 9,400 patients were monitored, with a median follow-up of 4.4 years. Key risk factors for progression included age, male gender, and Barrett’s length. This initiative anticipates reduced mortality through quality-assured surveillance and eradication therapies, achieving 100% cancer-specific survival.

Journal Article by Raftery NB, Elliott JA (…) Reynolds JV et 13 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Mini-laparoscopic cholecystectomy excels in obese patients

Mini-laparoscopic cholecystectomy (mlc) using a 5 mm umbilical port significantly improves outcomes for obese patients with gallstones. The mlc group experienced no port-site hernias, shorter operative times (46 minutes vs. 52), less postoperative pain, and a quicker return to daily activities. Patient satisfaction surged while in-hospital analgesic needs dropped. However, surgeon satisfaction dipped slightly with the smaller telescope. Overall, mlc outperforms traditional methods in safety and recovery, making it a compelling option.

Journal Article by Korayem IM, Bessa AS and Hassan RW in Surg Endosc

© 2025. The Author(s).

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New NTAA Model Transforms Prognosis for Liver Cancer Patients

The NTAA prognostic model redefines outcomes for BCLC stage B hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE). Analyzing over 2,500 patients, it identified tumor size, number, alpha-fetoprotein levels, and albumin-bilirubin grade as key survival predictors. Dividing patients into low, intermediate, and high-risk groups revealed median survival rates of 68.1, 35.7, and 15.4 months, respectively. The model outperforms traditional criteria, enhancing clinical decision-making and personalizing treatment strategies.

Journal Article by Chen S, Shen L (…) Fan W et 17 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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EUS-BD Outperform BEA-ERCP in Complex Biliary Obstruction

In a multicenter study, endoscopic ultrasound-guided biliary drainage (EUS-BD) demonstrated superior efficacy to balloon enteroscopy-assisted ERCP (BEA-ERCP) for patients with surgically altered anatomy and unresectable malignant biliary obstruction. EUS-BD achieved a significantly higher technical success rate and shorter procedure times, while maintaining similar clinical success and adverse event rates. BEA-ERCP was identified as an independent predictor of technical failure, particularly in patients with Roux-en-Y reconstruction.

Journal Article by Itonaga M, Takenaka M (…) Kitano M et 16 al. in Dig Endosc

© 2025 Japan Gastroenterological Endoscopy Society.

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Robotic Surgery Beats Laparoscopy in Rectal Cancer Recovery

Robotic colorectal surgery (RCS) significantly accelerates bowel function recovery and reduces major complications compared to laparoscopic colorectal surgery (LCS). In a meta-analysis of 1,731 patients, RCS showed a 0.62-day improvement in bowel function, a 30% decrease in major complications, and a lower conversion rate to open surgery. Although RCS required 22.7 additional minutes of operative time, its advantages in recovery and precision support its expanded use in colorectal cancer treatment.

Review by Mirza W, Dadan S, Khan HM and Yasmin S in J Robot Surg

© 2025. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

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New Benchmarks for Liver Surgery in Colorectal Metastases

Liver resection demonstrates strong oncologic outcomes for colorectal liver metastases (CRLM), with a 90-day mortality rate below 5%. One-year overall survival (OS) rates exceed 85% for most patients, dropping to 78% for those with ten or more metastases. Five-year OS rates range from 28% to 67%, depending on tumor burden. These findings establish critical benchmarks that can guide the evaluation of emerging treatment options like thermal ablation and transplantation.

Journal Article by Viganò L, Risi L (…) Adam R et 12 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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