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Nomogram effectively predicts intra-abdominal infection risk post-gastrectomy

A nutrition-based nomogram has been developed to predict the risk of intra-abdominal infection (IAI) after D2 radical gastrectomy for gastric cancer. An analysis of 404 patients identified key indicators, including the NRS2002 score, fasting blood glucose, and multi-visceral resection, associating them with IAI risk. The nomogram demonstrated good predictive capacity (AUROC 0.744) and excellent calibration, providing clinicians a valuable tool for assessing postoperative complications effectively.

Journal Article by Ma X, Jiang X (…) Lu X et 3 al. in Langenbecks Arch Surg

© 2025. The Author(s).

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Amino acid profiles may predict postoperative recovery in gastric cancer patients.

Significant preoperative amino acid elevations were found in gastric cancer patients. Post-surgery, many amino acids decreased but were partially restored with nutritional intervention, with some levels surpassing preoperative values. However, methionine and glutamine remained lower than in healthy individuals. Correlations were identified between specific amino acid changes and faster gastrointestinal recovery as well as reduced inflammation. These findings suggest that targeted amino acid supplementation may enhance postoperative outcomes and serve as biomarkers for recovery.

Journal Article by Guo Z, Xiang Z (…) Pan J et 8 al. in World J Surg Oncol

© 2025. The Author(s).

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EUS-guided gallbladder drainage proves effective for acute cholecystitis

EUS-guided gallbladder drainage (EUS-GBD) is emerging as a safe, effective solution for managing acute cholecystitis in patients unfit for surgery. Recent findings indicate improved technical and clinical outcomes, especially with the use of lumen-apposing metal stents, which facilitate direct gallbladder inspection. The study emphasizes the necessity of standardized techniques and precise patient selection, while highlighting the need for ongoing research to refine clinical indications and assess long-term outcomes.

Review by Marasco M, Signoretti M (…) Galasso D et 3 al. in Expert Rev Gastroenterol Hepatol

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Lactated Ringer’s solution improves outcomes in acute pancreatitis

A meta-analysis of 1500 patients found that lactated Ringer’s (LR) solution significantly reduces the risk of progressing to moderate-to-severe acute pancreatitis compared to normal saline (NS), with an odds ratio of 0.48. Patients receiving LR also experienced shorter hospital stays and lower ICU admission rates. Additionally, the incidence of local complications was reduced in the LR group. However, no significant differences in mortality or organ failure rates were noted between the two treatment groups.

Journal Article by Zhao T, Kang Z (…) Zhu SK et 6 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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New model predicts treatment response in liver cancer therapy

A deep learning-based clinical-radiomics model has shown strong predictive capability for durable clinical benefit (dcb) in patients with potentially convertible hepatocellular carcinoma receiving immune checkpoint inhibitors (ICIs). The model achieved an area under the curve (AUC) of 0.96 in training and 0.88 in testing, accurately stratifying survival risk and revealing significant disparities in overall survival. Additionally, the model’s scores correlated with immune-related factors, highlighting connections to mutations and immune mechanisms in effective treatment outcomes.

Journal Article by Lin Z, Wang W (…) Mao K et 3 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Robotic technique improves safety in gastric conduit reconstruction

A novel robotic approach for the retrosternal route in gastric conduit reconstruction has demonstrated safety and efficiency. In a study involving 43 esophageal cancer patients, the median time for creating this route was just nine minutes, with no incidences of pleural injury or postoperative hemorrhage reported. Additionally, there was no significant variation in creation time among the four surgeons, indicating the technique’s ease of learning and execution.

Journal Article by Tsuji T, Inaki N (…) Kinoshita J et 7 al. in Minim Invasive Ther Allied Technol

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New fluorescent probes enhance surgical navigation for liver cancer

Recent advancements in fluorescence-guided surgery provide significant improvements in identifying hepatocellular carcinoma (HCC) lesions. Indocyanine green has been essential for delineating tumor boundaries yet lacks the ability to differentiate between benign and malignant tumors. This review discusses clinical applications and emerging alternatives, such as aggregation-induced emission probes, which demonstrate enhanced fluorescence and stability. These innovative probes may facilitate more precise and effective real-time navigation during liver cancer surgeries, ultimately improving patient outcomes.

Review by Xiao T, Chen D (…) Li M et 5 al. in J Clin Transl Hepatol

© 2025 Authors.

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Navigation system improves robotic gastrectomy outcomes for novices

A vascular navigation system significantly enhances robotic distal gastrectomy for novice surgeons, according to a study involving 49 patients. The navigation group showed reduced dissection times (179.85 vs. 204.87 minutes) and increased lymph node retrieval (41.81 vs. 30.96). Additionally, the system contributed to lower C-reactive protein levels, indicating reduced surgical trauma (8.27 vs. 11.68 mg/dl). Notably, complication rates and recovery remained unchanged, emphasizing the system’s role in improving efficiency without introducing additional risks.

Journal Article by Chung JH, Lim D, Lee SH and Hwang SH in J Robot Surg

© 2025. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature.

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Detection of mutant KRAS ctDNA predicts metastatic risk in pancreatic cancer.

In a cohort study of 785 patients with pancreatic ductal adenocarcinoma, the presence of mutant KRAS circulating tumor DNA (ctDNA) was linked to higher metastatic risk and poorer survival outcomes. Out of those tested, 104 showed plasma MKRAS positivity, correlating with increased likelihood of metastatic disease. Furthermore, among 419 patients tested for peritoneal MKRAS, 123 were positive, revealing a tendency towards occult metastases. Overall, MKRAS detection significantly impacts prognosis and treatment strategies in localized PDAC cases.

Journal Article by Leiting JL, Alva-Ruiz R (…) Truty MJ et 15 al. in Ann Surg Oncol

© 2025. The Author(s).

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Simulation-based education enhances surgical training transitions

Effective simulation-based education interventions are essential for addressing risks associated with transitional phases in surgical careers. These programs, developed by the American College of Surgeons, focus on key transitions—from medical school to residency and into practice—promoting cognitive, technical, and non-technical skills. Emphasizing competency and mastery-based approaches, along with tailored educational methods like mentoring and proctoring, these initiatives aim to improve safety in patient care while nurturing future leaders in surgical education.

Journal Article by Sachdeva AK in BMC Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

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