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New Staging System Enhances Prognostication in Colon Cancer

A novel staging system integrating tumor deposits and positive lymph nodes significantly improved overall survival stratification in stage III colon cancer compared to existing AJCC staging. Analysis of 788 institutional and 77,790 national patients revealed increased ROC curve areas and concordance indices, demonstrating better prognostic accuracy. Notably, approximately 17.1% of patients were identified as understaged. These findings support the implementation of Sassun-Mayo N/TNM staging to enhance prognostic assessments in colon cancer.

Journal Article by Sassun R, Sileo A (…) Larson DW et 6 al. in JAMA Surg

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Research highlights global trends in necrotizing pancreatitis studies

The analysis of 929 articles on necrotizing pancreatitis revealed China as the leading contributor, followed by the United States and India. Notable findings included a focus on minimally invasive treatments, with key publications in specialized journals like “Pancreatology.” Despite increased research efforts over the past decade, the mortality rate for pancreatic necrosis remains concerning, indicating ongoing challenges in managing acute pancreatitis complications and emphasizing the need for innovative therapeutic strategies to enhance patient outcomes.

Systematic Review by Gainollina GG, Jakanov MK (…) Kurmanbayev BA et 3 al. in Front Med (Lausanne)

Copyright © 2025 Gainollina, Jakanov, Zhakiev, Karsakbayev, Taishibayev and Kurmanbayev.

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Surgeons Experience Emotional Distress from Caring for Dying Patients

A systematic scoping review reveals that surgeons face significant emotional turmoil while caring for dying patients and their families. The study, analyzing 26 articles, found that without personalized and timely support, surgeons are at risk of depression, burnout, and substance abuse, impacting patient safety and satisfaction. Key themes identified include the effects on personal identity and various predisposing factors related to this distress. The need for robust assessment tools to support surgeons is critical.

Systematic Review by Tan JR, Ong YT (…) Krishna LKR et 4 al. in BMC Surg

© 2025. The Author(s).

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Explainable machine learning model predicts mortality in infected pancreatic necrosis

An explainable machine learning model for predicting 90-day mortality in patients with infected pancreatic necrosis (IPN) has shown promising results. The final model, developed from a cohort of 344 patients, achieved a c-index of 0.863 in internal validation and 0.857 in external validation, outperforming nine other models. Key mortality predictors included multiple organ failure and acute physiology scores. The model’s utility is enhanced by two web-based applications, improving clinical decision-making and patient outcomes.

Journal Article by Ning C, Ouyang H (…) Huang G et 12 al. in EClinicalMedicine

© 2025 The Author(s).

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High prevalence of combat injuries in Ukraine demands better prevention

A qualitative assessment revealed that complex polytrauma is the norm among Ukrainian combatants, with significant injuries such as blast wounds, traumatic brain injuries, and spinal cord trauma prevalent. Limited injury prevention measures were identified, primarily relying on combat body armor. Despite the need, respondents noted a lack of formal processes to use data for injury prevention. Recommendations include improved protective gear and establishing a trauma registry to enhance understanding of combat-related injuries and preventive strategies.

Journal Article by Lawry LL, Mani V (…) Koehlmoos TP et 7 al. in BMJ Mil Health

© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.

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KRAS mutations in duodenal fluid improve pancreatic cancer detection

KRAS mutations identified in duodenal lavage fluid after secretin stimulation demonstrated a high diagnostic accuracy for detecting resectable pancreatic ductal adenocarcinoma (pdac). With an area Under the Curve (AUC) of 0.934, the method achieved a sensitivity of 83.1% at 100% specificity, significantly outperforming traditional serum biomarkers. This innovative approach enhances early detection, which is crucial for effective pdac management and increasing survival rates, underscoring the potential for less invasive diagnostic techniques.

Journal Article by Yachida S, Yoshinaga S (…) Matsumoto K et 26 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Dual-time-point radiomic models enhance prognosis prediction for colorectal liver metastasis

The dual-time-point radiomic models, developed using pre- and post-neoadjuvant therapy MRI features, effectively stratified colorectal liver metastasis patients undergoing surgery. In a study with 100 cases, post-neoadjuvant therapy models showed superior predictive power in overall and disease-free survival compared to pre-neoadjuvant therapy models. Fong score models did not perform as well. The integration of radiomic features with clinical and pathological variables led to significant improvements in the prognostic assessment of patients.

Journal Article by Li ZF, Zhang JN (…) Ye ZX et 3 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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AI framework quantifies clinical influences on posthepatectomy length of stay

An innovative artificial intelligence framework was developed to quantify the impact of clinical factors on posthepatectomy length of stay (LOS), explaining 75% of its variability. The study analyzed 21,039 patients, revealing that clinical influences are significant while nonclinical factors account for the remaining 25%. Notably, major resections had a longer mean LOS of 6.9 days compared to 5.0 days for minor resections. Random forest models demonstrated the strongest performance among the tested methodologies.

Journal Article by Putman K, Moheb ME (…) Tsung A et 3 al. in Ann Surg Oncol

© 2025. The Author(s).

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High acute postoperative pain increases risk of chronic pain

Analysis of 1170 elective abdominal surgery patients revealed two acute pain trajectory clusters: high and low. Those in the high pain groups experienced almost double the likelihood of developing chronic postsurgical pain (cpsp), along with a significantly poorer recovery quality. Mediation analysis indicated that the quality of recovery within the first five days and subacute pain levels at one month post-surgery are critical mediators linking acute pain trajectories to cpsp risk, highlighting the need for targeted management strategies.

Journal Article by Chen DX, Zhang YY, Liu J and Chen Y in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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New guidelines enhance prehospital bleeding control strategies

A systematic review produced fourteen new consensus-based recommendations for prehospital bleeding control in patients with multiple and/or severe injuries. Analyzing fifteen studies on interventions such as tourniquets and pelvic binders, researchers highlighted the importance of bleeding control as a treatment objective. Despite the strong consensus on these recommendations, the review reveals a significant gap in high-quality studies that compare different bleeding control methods, leaving several research questions unanswered for future guidelines.

Review by Trentzsch H, Goossen K (…) Bieler D et 10 al. in Eur J Trauma Emerg Surg

© 2025. The Author(s).

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