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Robot-assisted pancreatoduodenectomy costs become comparable to traditional methods.

A post-hoc analysis of 588 patients revealed that while robot-assisted pancreatoduodenectomy (rpd) incurs initial higher costs compared to open pancreatoduodenectomy (opd), outcomes improve significantly with experience. Total hospital stay shortened from 12 to 9 days, and costs per rpd procedure decreased from €32,836 to €21,778. By the second half of the study, total costs for rpd were comparable to opd (€21,778 vs. €21,013), suggesting rpd’s evolving cost efficiency.

Journal Article by Menso JE, Francken MFG (…) Besselink MG et 17 al. in Ann Surg

Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.

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Patients with gastrointestinal cancers show low knowledge and practices.

A study involving 408 patients with gastrointestinal cancers revealed inadequate knowledge, moderate attitudes, and suboptimal practices regarding whole-course management. Mean scores indicated a significant deficit in understanding, with knowledge influencing both attitudes and practices positively. The structural equation model underscored that enhancing knowledge could lead to improved attitudes and practices. Findings suggest that targeted health education may enhance patients’ management of their condition, ultimately improving health outcomes.

Journal Article by Huang M, Feng L (…) Yang L et 6 al. in World J Surg Oncol

© 2025. The Author(s).

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New laparoscopic approach enhances outcomes for colon cancer surgery

A novel laparoscopic technique combining priority dissecting of the inferior mesenteric artery with a complete medial approach significantly improved surgical outcomes for left-sided colon cancer. In a study of 68 matched patients, those using the new method experienced shorter operation times (p=0.032), reduced blood loss (p=0.003), and a quicker hospital stay (p=0.011), while also harvesting more lymph nodes. Importantly, the method did not increase perioperative complications compared to traditional approaches.

Journal Article by Wang Y, Hu G (…) Tang J et 5 al. in World J Surg Oncol

© 2025. The Author(s).

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Transabdominal ultrasonography effectively detects bile duct obstructions

Transabdominal ultrasonography (TAUS) shows high compatibility with endoscopic retrograde cholangiopancreatography (ERCP) in diagnosing bile duct obstructive lesions. A retrospective study analyzed patient data and found substantial agreement in identifying conditions such as cholangiocarcinoma, bile duct stricture, and pancreatic cancer, with compatibility rates between 71.4% and 100%. TAUS offers a reliable, non-invasive, and radiation-free imaging option for patients with obstructive jaundice, posing minimal risk of serious complications.

Journal Article by Binnuhaid AA, Alshoabi SA (…) Qurashi AA et 3 al. in Pak J Med Sci

Copyright: © Pakistan Journal of Medical Sciences.

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Percutaneous catheter drainage is a safe alternative for abscess management

In a study involving 90 patients with periappendiceal abscesses, ultrasound-guided percutaneous catheter drainage (PCD) combined with antibiotics demonstrated significant advantages over emergency laparoscopic surgery (ELS). The PCD approach resulted in shorter operative times, fewer postoperative complications, and reduced hospital stays. These results highlight PCD’s efficacy as a viable alternative to surgical intervention, yielding benefits that can alleviate patient discomfort and optimize healthcare resources, although further multicenter research is necessary for broader validation.

Journal Article by Ding YB, Wang WN and Zhan XL in Pak J Med Sci

Copyright: © Pakistan Journal of Medical Sciences.

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Metabolic Changes and GLP-1 Levels Predict Liver Failure

Significant metabolic alterations and the dynamics of GLP-1 and GLP-2 were identified during liver resection in patients, particularly linking these changes to posthepatectomy liver failure (PHLF). Of the patients studied, metabolic clustering showed that 93% of PHLF individuals fell within one cluster. Preoperative GLP-1 levels were notably elevated in PHLF patients, and its incorporation into existing predictive models improved PHLF prediction, highlighting its potential role in assessing liver regeneration outcomes.

Journal Article by Ammann M, Jonas JP (…) Starlinger PP et 14 al. in Hepatobiliary Surg Nutr

Copyright © 2025 AME Publishing Company. All rights reserved.

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Nanovesicles enhance chemosensitivity in cholangiocarcinoma models

Aptamer-decorated milk-derived nanovesicles (mnvs) effectively targeted cholangiocarcinoma (cca) cells, promoting the delivery of short interfering RNAs (siRNAs) that inhibited key gene expressions. This selective uptake led to reduced tumor growth and increased reactive oxygen species production. Notably, the combined treatment with nanovesicles and chemotherapy showed enhanced therapeutic efficacy in both immunocompetent and patient-derived xenograft models. The study highlights a promising strategy to improve treatment options for patients with this aggressive malignancy.

Journal Article by Yu M, Sample JW (…) Smoot RL et 16 al. in Hepatology

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Prognostic factors vary between neoadjuvant and chemo-naïve patients.

Neoadjuvant therapy changes the prognostic landscape for patients with resected pancreatic ductal adenocarcinoma (PDAC). In a study of 2,760 patients, independent predictors of overall survival (OS) differed significantly: chemotherapy-naïve patients were affected by age, CA19-9 levels, and tumor stage, while neoadjuvant therapy patients faced challenges like CA19-9 normalization and nodal presence. These insights led to online personalized prediction tools designed to enhance patient prognostication.

Journal Article by Javed AA, Habib JR (…) Daamen LA et 15 al. in Ann Surg

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New silicone model enhances laparoscopic appendectomy training

A novel silicone model developed for laparoscopic appendectomy training demonstrated high effectiveness among first-year surgical residents. Participants who used the model reported increased confidence and solid foundational learning. The study revealed that those with more experience using the model outperformed others, highlighting its educational value. Feedback from 91% of trainees indicated strong approval of the model’s adequacy for simulation. This low-cost approach shows promise in improving surgical education and training for young residents.

Journal Article by Gonçalves MR, Marinho R (…) Castelo-Branco Sousa M et 6 al. in Updates Surg

© 2025. The Author(s).

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Preferred technique for gastrostomy feeding tubes identified

A guideline by the American Society for Gastrointestinal Endoscopy recommends percutaneous endoscopic gastrostomy (PEG) as the preferred method for initial enteral access over interventional radiology-guided gastrostomy. The article details recommendations regarding medication management, stating tube feeding can safely commence within four hours post-procedure. It emphasizes that antiplatelet medications can generally be continued, while anticoagulation management decisions should involve a multidisciplinary approach, particularly for patients with malignant dysphagia.

Journal Article by None None, Kohli DR (…) Qumseya BJ et 18 al. in VideoGIE

© 2025 by the American Society for Gastrointestinal Endoscopy. Published by Elsevier, Inc.

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