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Combination of IRE and β-Glucan Improves Survival in Pancreatic Cancer

A Phase II trial demonstrated that combining irreversible electroporation (IRE) with β-glucan significantly improved disease-free intervals and overall survival in patients with stage III pancreatic ductal adenocarcinoma. The study included 30 patients treated with IRE followed by β-glucan, showing a median disease-free interval of 18 months and a median overall survival of 32.5 months. Notably, immunophenotyping revealed enhanced anti-tumor responses, highlighting the potential of this combination therapy.

Journal Article by Martin RC, Li Y (…) Yan J et 7 al. in J Am Coll Surg

Copyright © 2025 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Nomogram effectively predicts postoperative pneumonia post-esophageal ESD

A novel nomogram has been developed to predict postoperative pneumonia risk after esophageal endoscopic submucosal dissection (ESD). In a cohort of 492 patients, the incidence of pneumonia was 18.6%. Key predictive factors included female sex, older age, low serum albumin levels, prolonged operative duration, muscular layer damage, and comorbid pulmonary diseases. The nomogram exhibited robust predictive capabilities, validated with an area under the curve of 0.76 and 0.89 for internal and external validation cohorts, respectively.

Journal Article by Xia SY, Lu Q (…) Yang JL et 4 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Tumor downstaging improves survival in esophageal adenocarcinoma patients

Analysis of 6,400 esophageal adenocarcinoma patients revealed that 51% experienced tumor downstaging after neoadjuvant chemoradiation, with complete downstaging noted in 5%. Downstaging correlated with a 31% and 17% reduced risk of death compared to disease progression and stable staging, respectively. Additionally, robotic-assisted minimally invasive esophagectomy reduced mortality risk by 17% compared to open surgery, while minimally invasive surgery showed a 10% decrease. These findings underscore the impact of therapeutic approaches on survival outcomes.

Journal Article by Canto EA, Reilly M (…) Nandipati KC et 2 al. in Surg Endosc

© 2025. The Author(s).

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Pancreatic neuroendocrine tumor resections lead to poorer outcomes

Observational data indicate that pancreatic resections for neuroendocrine tumors (pnet) result in a significantly lower rate of ideal outcomes compared to pancreatic ductal adenocarcinoma (pdac) patients. The ideal outcome rate was 47.7% for pnet versus 55.7% for pdac, primarily due to a fourfold increase in postoperative pancreatic fistulas after pancreatoduodenectomy for pnet. This difference emphasizes the necessity for tailored patient counseling and the development of strategies to mitigate complications.

Journal Article by Chen JW, Augustinus SA (…) Nieveen van Dijkum EJM et 8 al. in HPB (Oxford)

Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Early refeeding reduces complications after colorectal cancer surgery.

A study involving 275 colorectal cancer patients revealed that early postoperative refeeding significantly reduces the risk of infectious complications and hospital stays exceeding five days. Specifically, late refeeding, use of nasogastric tubes, and intra-abdominal drains were identified as factors that increase complications. The findings indicate that early refeeding should be prioritized to enhance recovery and minimize risks associated with prolonged hospitalization. 75.4% of patients in the study received early refeeding.

Journal Article by Frizon E, Aguilar-Nascimento JE (…) Dock-Nascimento DB et 4 al. in Arq Bras Cir Dig

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EUS-directed approach resolves jaundice in patients with obstructions

A novel EUS-guided technique utilizing lumen-apposing metal stents effectively treated patients with concomitant gastric outlet and biliary obstructions. In a study involving nine severely ill individuals, complete resolution of jaundice was achieved in all cases, attributed to successful transduodenal ERCP via gastroduodenal stenting. Post-procedure evaluations showed significant improvements in gastric outlet obstruction scores across all patients, indicating the method’s potential for future interventions in poor surgical candidates.

Journal Article by Kesar V, Abel WF (…) Yeaton P et 6 al. in Gastrointest Endosc

Copyright © 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

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Risk model predicts surgical adverse events in esophagectomy patients

A risk stratification model for surgical adverse events (SAEs) in minimally invasive esophagectomy (MIE) was developed and validated using data from 747 patients. The model identified key risk factors, including chronic obstructive pulmonary disease and low albumin levels, achieving areas under the curve of 0.889 and 0.793 for the training and validation sets, respectively. Patients experiencing SAEs had notably longer hospital stays and higher complication rates, underscoring the model’s potential in enhancing preoperative management.

Validation Study by Zhong QH, Huang JS (…) Lin JB et 7 al. in World J Gastroenterol

©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

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DCNN Model Enhances Early Gastric Cancer Diagnosis

A study established a deep convolutional neural network (DCNN) system that significantly improved diagnostic accuracy for early gastric cancer (EGC). In independent tests, the model achieved an area under the curve (AUC) of 0.917 and sensitivity of 93.38% for image datasets, while video tests showed an AUC of 0.930 and 96.92% sensitivity. Novice endoscopists reached near-expert accuracy levels with DCNN support, and overall diagnostic times decreased, demonstrating the system’s potential in clinical settings.

Journal Article by Feng J, Zhang Y (…) Huang X et 6 al. in Surg Endosc

© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Consensus guidelines enhance surgical management of colorectal liver metastases

A consensus guideline developed by the AHPBA highlights the significant role of surgical management in colorectal liver metastases (CRLM), emphasizing early surgical involvement for improved patient survival. It outlines the effectiveness and limitations of diagnostic tools, including imaging and next-generation sequencing. The guidelines advocate for treatment sequencing, combining surgical and non-surgical approaches, especially in cases of unresectable disease, to optimize outcomes for patients facing this complex diagnosis.

Practice Guideline by None None in HPB (Oxford)

Copyright © 2024 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

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Improved survival linked to histological remission post-bariatric surgery

Histological remission of metabolic dysfunction-associated steatohepatitis (MASH) and significant fibrosis enhances survival rates post-bariatric surgery. In a cohort of 3028 patients over a median follow-up of 10.1 years, those with persistent MASH or worsening fibrosis exhibited increased mortality, while those whose MASH resolved without fibrosis worsening showed no increased risk. Survival was significantly prolonged in patients with improved histological status compared to those with persistent conditions, highlighting the importance of monitoring liver health post-surgery.

Journal Article by Lassailly G, Caiazzo R (…) Mathurin P et 15 al. in Clin Gastroenterol Hepatol

Copyright © 2024 AGA Institute. Published by Elsevier Inc. All rights reserved.

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