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Endoscopic gastrojejunostomy shows benefits over surgical options

Findings indicate that endoscopic gastrojejunostomy (EGJ) is associated with fewer peri-procedural complications compared to surgical gastrojejunostomy (SGJ) for patients with malignant gastric outlet obstruction. Data from over 20,000 hospitalizations from 2016 to 2020 revealed that EGJ resulted in lower rates of respiratory failure, blood transfusions, and peritonitis, alongside reduced hospitalization costs and shorter stays. The preference for EGJ has grown, while use of SGJ has declined during this period.

Journal Article by Pinnam BSM, Ojemolon PE (…) Inamdar S et 11 al. in Gastrointest Endosc

Copyright © 2025 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

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New survival model offers real-time predictions for gastric cancer

A dynamic survival prediction model for gastric neuroendocrine carcinoma (GNEC) was developed using machine learning and conditional survival (CS) analysis. Data from 654 patients were split into training and validation sets. The CS model demonstrated improved 5-year survival probabilities, rising from 48% at diagnosis to 94% after four years. Key prognostic factors—age, tumor grade, stage, surgery, and chemotherapy—were identified, forming the basis of a nomogram that effectively stratified patients by risk and improved survival prediction.

Journal Article by Ding F, Zhuang Y and Chen S in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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Nomogram predicts complications in robotic radical gastrectomy patients

A predictive nomogram was developed to assess the risk of postoperative complications in gastric cancer patients undergoing robotic-assisted radical gastrectomy. The study analyzed data from 636 patients across two cohorts and identified five independent risk factors: tumor diameter, TNM stage III, ASA classes I and III, and visceral fat area. The nomogram demonstrated good discrimination, with AUC values of 0.81 for internal validation and 0.79 for external validation, proving useful for clinical decision-making.

Validation Study by Ma Y, Deng Y (…) Ma Y et 7 al. in Langenbecks Arch Surg

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Deep learning algorithm excels in kidney trauma detection

A deep learning model, RenotrNet, demonstrated high accuracy in detecting kidney trauma on CT scans, achieving 0.88 accuracy in internal testing and 0.93 in external validation with RSNA data. The model showed robust performance metrics, including 0.75 sensitivity and 0.95 specificity internally, and 0.73 sensitivity and 0.94 specificity externally. Its high negative predictive value of 0.98 suggests substantial reliability, highlighting its potential for clinical deployment in trauma diagnosis.

Journal Article by Liao CH, Ouyang CH (…) Cheng CT et 6 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Bismuth subgallate-borneol ointment enhances healing in surgical wounds

A novel bismuth subgallate-borneol compound ointment significantly improved wound healing in infectious postoperative wounds after anorectal surgery. In a randomized controlled trial involving 46 patients, the experimental group showed a higher granulation growth rate at all observation points and a notable increase in wound healing rate by day 14 compared to the control group. These results suggest that the ointment’s antibacterial properties effectively promote healing when used alongside standard care.

Randomized Controlled Trial by Yu L, Lei Y and Yuan K in Medicine (Baltimore)

Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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Predictive model enhances surgical options for liver tumor patients

A predictive model for identifying intrahepatic collateral vessels in patients with caval confluence tumors reveals that 78% exhibited such vessels. Out of those, 92% underwent parenchyma-sparing hepatectomies, with zero operative mortality and no liver congestion reported. The study established tumor size, number, hepatic vein infiltration, and tissue density as key predictors for the presence of these vessels, achieving an 82% discrimination rate. This model could significantly guide surgical strategies and improve resectability.

Journal Article by Procopio F, Galvanin J (…) Torzilli G et 5 al. in BMC Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

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Methylated ctDNA predicts outcomes in liver metastases treatment

A prospective study of 56 colorectal cancer patients reveals that preoperative circulating tumor DNA (meth-ctDNA) serves as a significant biomarker for assessing treatment plans. Negative preoperative meth-ctDNA correlates with longer median progression-free survival (PFS), identified as a strong independent predictor (HR=3.3). Similarly, negative postoperative meth-ctDNA also indicates improved survival outcomes. This study suggests that assessing meth-ctDNA can inform multidisciplinary decisions regarding the timing and nature of liver interventions and chemotherapy for colorectal liver metastases.

Journal Article by Raunkilde L, Andersen RF (…) Jensen LH et 2 al. in Eur J Surg Oncol

Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Eight interventions proved effective in preventing post-operative stenosis

A systematic review and network meta-analysis identified eight effective interventions for preventing postoperative esophageal stenosis following endoscopic resection of superficial cancer. Notable approaches included the combination of polyglycolic acid with a steroid and botulinum toxin. These interventions also led to significant reductions in the number of endoscopic balloon dilatation sessions needed. Importantly, none of the interventions were associated with increased complications, underscoring their safety and efficacy.

Journal Article by Dong Y, Xu H (…) Lin Z et 7 al. in Int J Surg

Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc.

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Laparoscopic surgery shows benefits for metachronous colorectal cancer patients

In a comparative study of 59 patients with metachronous colorectal cancer, laparoscopic surgery demonstrated significant advantages over open surgery. Patients who underwent laparoscopic procedures experienced less blood loss (56.80 ml vs. 136.47 ml), faster recovery of bowel function, and shorter hospital stays (7.24 days vs. 10.79 days). Additionally, those in the laparoscopic group returned to bowel function more quickly, with a time to first flatus of 2.20 days compared to 3.50 days in the open group.

Comparative Study by Li J, Tian R (…) Zheng Z et 2 al. in BMC Surg

© 2025. The Author(s).

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Tumor-Stroma Ratio Accurately Predicts Peritoneal Metastasis in Gastric Cancer

Analysis reveals a strong correlation between tumor-stroma ratio (tsr) and peritoneal metastasis (pm) in gastric cancer patients. The study included 640 patients across several cohorts, establishing a diagnostic model integrating tsr with CA125, CA724, and Borrmann type. The model demonstrated robust predictive capabilities, achieving an area under the curve (AUC) of 0.85 in the training cohort and 0.73 in external validation. Ultimately, tsr serves as a critical marker for diagnosing pm in gastric cancer.

Journal Article by Zhong L, Huang H (…) Xie L et 6 al. in Clin Exp Gastroenterol

© 2025 Zhong et al.

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