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Textbook outcomes enhance survival for pancreatic cancer patients.

A retrospective analysis of 111 pancreatic cancer patients undergoing pancreaticoduodenectomy revealed that 62.2% achieved textbook outcomes, significantly improving overall survival (OS) [p=0.03; HR=0.60]. Cox regression identified achievement of these outcomes as a protective factor for OS [p=0.04; HR=4.08]. Key barriers to achieving textbook outcomes included high amylase levels, prolonged surgery duration, and soft pancreatic texture, underscoring their importance in surgical quality control measures.

Journal Article by Wang H, Hu X (…) Zhang H et 4 al. in Transl Gastroenterol Hepatol

2024 Translational Gastroenterology and Hepatology. All rights reserved.

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Shared molecular mechanisms identified between COVID-19 and pancreatic cancer

Gene expression analysis revealed 236 common differentially expressed genes (DEGs) between COVID-19 and pancreatic cancer (PC) patients. Functional enrichment pointed to pathways linked to viral replication and tumorigenesis. Ten hub genes, including cyclin-dependent kinase 1 and aurora kinase B, were identified, along with 42 transcription factors and 23 microRNAs that regulate gene expression. This research suggests therapeutic potential for agents like etoposide and methotrexate in treating both conditions, highlighting critical connections between them.

Journal Article by Fang C, Sun H (…) Zhai D et 3 al. in Medicine (Baltimore)

Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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Nomogram predicts posthepatectomy liver failure more effectively.

A novel nomogram, based on liver stiffness (ls) via 2D-sheared wave elastography and spleen area (spa), was developed to predict posthepatectomy liver failure (PHLF) in hepatocellular carcinoma patients. Analysis of 562 patients demonstrated superior diagnostic performance compared to conventional models, such as the MELD and ALBI scores. In the training cohort, the nomogram achieved an area under the curve (AUC) of 0.833, while in the validation cohort, it showed an AUC of 0.802, indicating high predictive accuracy.

Observational Study by Cheng GW, Fang Y (…) Ding H et 6 al. in World J Gastroenterol

©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

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Fundoplication leads to fewer complications than gastric fixation.

A retrospective cohort study analyzing 1,317 emergency hiatal hernia repairs revealed that fundoplication significantly reduced 30-day complication (odds ratio [OR] 0.53, p < 0.001) and mortality rates (OR 0.55, p = 0.033) compared to gastric fixation. No significant differences were found regarding 30-day readmission (OR 0.86, p = 0.449) or reoperation rates (OR 0.66, p = 0.063). Fundoplication emerges as a safe and feasible approach for managing hiatal hernias in urgent situations.

Journal Article by Srikrishnaraj D, Hawel J, Schlachta CM and Elnahas A in Surg Endosc

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Music intervention reduces hemodynamic fluctuations and anxiety in women.

Preoperative music significantly decreased hemodynamic instability and anxiety among women undergoing elective non-cardiac surgery. In a study involving 164 participants, those in the music intervention group exhibited lower mean arterial pressure fluctuations and heart rate instability compared to the control group. Furthermore, the State-Trait Anxiety Inventory scores post-intervention indicated a substantial reduction in anxiety levels, with a between-group difference of 8.01, highlighting the efficacy of music in enhancing perioperative experiences.

Journal Article by Wang J, Jiang L (…) Xiong W et 4 al. in Clinics (Sao Paulo)

Copyright © 2024. Published by Elsevier España, S.L.U.

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Increase in trauma-related injuries noted post-earthquake

A retrospective study analyzed 2,155 patients admitted after the February 2023 Kahramanmaraş earthquake. Falls accounted for 57.2% of injuries, with significant occurrences of rhabdomyolysis (20.6%) and fractures (11.1% upper, 21.3% lower extremities). The orthopedics department performed the most surgical interventions, revealing a critical need for healthcare professionals to manage increased workloads. Mortality reached 2.87%. Effective disaster preparedness can significantly alleviate healthcare crises and reduce associated morbidity and mortality.

• Why it matters: nan

Journal Article by Köseoğlu Z, Çolak T (…) Söker S et 5 al. in Ulus Travma Acil Cerrahi Derg

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Nomogram effectively predicts overall survival for gastric cancer patients.

The study developed a prognostic nomogram for gastric cancer patients post-neoadjuvant chemotherapy and radical surgery, revealing promising results. The median progression-free survival was 43.8 months, and overall survival reached 61.2 months. The nomogram demonstrated excellent discrimination with a c-index of 0.689 and area under the curve (AUC) values of 0.778, 0.746, and 0.725 for 3-, 5-, and 10-year overall survival, respectively. It outperformed traditional TNM and Japanese criteria, proving useful for clinical prognosis.

Journal Article by Wang Y, Zhang S (…) Liu T et 7 al. in Transl Gastroenterol Hepatol

2024 Translational Gastroenterology and Hepatology. All rights reserved.

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Early detection of infectious complications post-gastric cancer surgery

Elevated interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in serum and drainage fluid indicate infectious complications following minimally invasive gastric cancer surgery. Among 205 patients, pod 1 serum IL-6 levels above 47 pg/ml exhibited 74.1% sensitivity, while drainage fluid IL-6 levels over 14,750 pg/ml demonstrated 100% sensitivity for intra-abdominal abscess detection. These findings suggest that IL-6 measurement on postoperative day 1 can effectively identify potential infections early.

Journal Article by Itami T, Kurokawa Y (…) Doki Y et 10 al. in Eur J Surg Oncol

Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Anterior approach improves survival in liver resection surgeries

In a systematic review of six randomized controlled trials involving 736 patients, the anterior approach with or without liver hanging maneuver demonstrated significant survival benefits over conventional techniques. Overall and disease-free survival rates improved markedly (HR: 0.65; p < 0.0001). Although associated with longer surgery times (WMD: 29.5 min; p = 0.004), this approach resulted in reduced intraoperative blood loss (WMD: 24.3; p = 0.0014). Other postoperative outcomes showed no significant differences.

Review by Granieri S, Frassini S (…) Cotsoglou C et 10 al. in Eur J Surg Oncol

Copyright © 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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Combined use of diagnostic criteria significantly enhances appendicitis detection

Diagnostic accuracy for appendicitis improves beyond 90% when utilizing Alvarado criteria, ultrasound, and CRP together. Individual sensitivities showed Alvarado at 75.2% compared to ultrasound and CRP, which were higher. Analyses demonstrated that combinations, particularly Alvarado with CRP, outperformed others, indicating a need for a more integrated approach to diagnosing acute appendicitis. The study emphasizes the inadequacy of the Alvarado criteria alone and highlights significant advancements achieved through the concurrent application of all three modalities.

Journal Article by Tayebi A, Olamaeian F (…) Mehr DE et 5 al. in BMC Gastroenterol

© 2024. The Author(s).

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