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Effectiveness of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer

A meta-analysis of 16 randomized controlled trials with 1,641 patients assessed the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) for treating and preventing peritoneal carcinomatosis in advanced gastric cancer. Surgery plus HIPEC improved overall survival in both prophylactic (HR 0.56) and therapeutic (HR 0.57) settings, with a 3-year mortality rate of 32% for the prophylactic HIPEC group versus 55% for controls. Recurrence rates were reduced without significant differences in morbidity. HIPEC shows potential for treating and preventing peritoneal carcinomatosis, though more large-scale studies are needed for a definitive recommendation.

Review by Stefano M, Perrina D (…) Catena F et 13 al. in J Gastrointest Surg

Copyright © 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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Association Between Social Vulnerability and Outpatient Management of Symptomatic Cholelithiasis

Patients with symptomatic cholelithiasis from vulnerable regions are more likely to fail outpatient management, leading to recurrent ED visits. Socially vulnerable status, especially in terms of socioeconomic and minority groups, significantly increases the odds of management failure. Timely follow-up and elective cholecystectomy can help reduce overutilization of ED resources for these patients.

Journal Article by Sibia US, Klune JR (…) Essner R et 3 al. in J Gastrointest Surg

Copyright © 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.

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Long-term Efficacy of Imatinib Combined with Hepatic Resection for GIST Liver Metastases

Imatinib combined with hepatic resection significantly improves overall survival in patients with gastrointestinal stromal tumor liver metastases compared to imatinib monotherapy. Achieving no evidence of disease status through surgical intervention leads to prolonged overall survival, liver-specific progression-free survival, and progression-free survival. Age ≤60 years and combination therapy were independently associated with better outcomes.

Journal Article by Wen H, Huang Y (…) Zhang X et 11 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Computed Tomography Radiogenomics: Predicting Molecular Subtypes in Gastric Stromal Tumors

A combined model integrating clinical and contrast-enhanced computed tomography (CE-CT) features accurately predicts specific genetic mutations in gastrointestinal stromal tumors (GISTs). Researchers developed three models from data from 231 GIST patients, with the best model achieving high accuracy in predicting molecular subtypes. In the training cohort, the area under the curve (AUC) values indicated significant accuracy, suggesting that preoperative CE-CT radiogenomics may guide personalized precision therapy in GIST patients.

Journal Article by Yin XN, Wang ZH (…) Zhang B et 6 al. in World J Gastrointest Oncol

©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

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Effect of Compression Time on Postoperative Complications in Stapled Hemorrhoidopexy

Longer compression time (2 minutes) before stapler firing in staple hemorrhoidopexy resulted in decreased postoperative bleeding compared to typical compression time (30 seconds). Typical compression time was associated with higher rates of bleeding, additional procedures, and fecal urgency. No significant differences were found in dehiscence and stenosis rates between the groups.

Journal Article by Yoo BE, Kang WH (…) Lim CH et 2 al. in Ann Coloproctol

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Factors Influencing Variation in Postoperative Opioid Prescribing

Prescribing variation after surgery is largely influenced by prescriber-level factors, with a significant proportion of unwarranted variation in opioid quantities identified. Unwarranted covariates associated with higher opioid quantities include race, insurance status, smoking history, discharge times, and prescriber type. Targeting prescribers through education and training may effectively reduce excessive postoperative opioid prescribing practices.

Journal Article by Zanocco K, Romanelli RJ (…) Watkins KE et 7 al. in J Am Coll Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Surgeons.

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Benefit of Surgical Cytoreduction for Patients with Small Intestinal Neuroendocrine Tumors Metastatic to the Liver and Peritoneum

Complete cytoreduction can significantly improve survival and relieve symptoms in patients with small intestinal neuroendocrine tumors metastatic to the liver and peritoneum. Despite initial controversies, achieving complete cytoreduction yielded comparable outcomes in patients with isolated liver metastases and those with liver and peritoneal metastases. Aggressive surgical cytoreduction should be considered even in the presence of peritoneal metastases for favorable patient outcomes.

Journal Article by Gudmundsdottir H, Fogliati A (…) Starlinger P et 9 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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Whole Blood Hemostatic Resuscitation in Geriatric Trauma: Impact on Mortality

A nationwide study examined the impact of whole blood (WB) hemostatic resuscitation on geriatric trauma patients with severe hemorrhagic shock. Among 1,194 patients identified, 141 (12%) received WB in addition to component therapy (CT). Multivariable analysis revealed that WB use was associated with reduced 24-hour mortality (odds ratio 0.62, 95% CI 0.41-0.94, p = 0.024) and in-hospital mortality (odds ratio 0.60, 95% CI 0.40-0.90, p = 0.013) compared to CT alone. These findings suggest WB resuscitation may improve early and overall mortality in geriatric trauma patients with hemorrhagic shock.

Journal Article by Hosseinpour H, Anand T (…) Joseph B et 7 al. in J Surg Res

Copyright © 2024 Elsevier Inc. All rights reserved.

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Management of Recurrent Laryngeal Nerve Infiltrated by Thyroid Carcinoma

Novel intraoperative phonosurgical management significantly improved voice quality post-surgery in patients with thyroid carcinoma infiltrating the recurrent laryngeal nerve. Resection and arytenoid adduction for medullary thyroid cancer, resection and ansa cervicalis-to-rln anastomosis for well-differentiated thyroid cancer with preoperative paralysis, and rln preservation for patients with normal vocal fold mobility showed promising outcomes.

Journal Article by Peng J, Zhu G (…) Wang W et 9 al. in Langenbecks Arch Surg

© 2024. The Author(s).

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A Novel Groin Hernia Classification Incorporating Clinical Parameters

Researchers have developed a new groin hernia classification system that integrates clinical elements with anatomical details, providing a comprehensive framework to stratify patients by disease severity. This system consists of nine grades and allows more precise data collection for future audits, monitoring disease progression, and assessing the impact of different management strategies. Initial evaluation involved a task force from the Hong Kong Hernia Society and application to a single hernia surgeon’s registry. Further validation studies are recommended to confirm its utility in clinical practice.

Journal Article by Yang G, Tung KLM, Tumtavitikul S and Li MKW in Hernia

© 2024. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature.

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