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Global Trends in Early-Onset Pancreatic Cancer: A 30-Year Analysis

Early-onset pancreatic cancer (EOPC) is increasing globally, particularly in Asia, with high burden in central and eastern Europe. From 1990 to 2019, EOPC saw a rise in incidence, mortality, and disability-adjusted life-years (DALYs). Risk factors include smoking, high BMI, and high glucose levels. Prevention strategies targeted at high-risk populations are essential to curb this growing health threat.

Journal Article by Li Z, Zhang X (…) Zhao D et 3 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Predicting Overall Survival in GEP-NETs Using a Treatment Data Nomogram

A nomogram incorporating treatment data proved better than the AJCC staging system in predicting overall survival for gastroenteropancreatic neuroendocrine tumors. Key factors include sex, age, race, tumor location, and treatment modalities. Internal and external validation showed superior performance, advocating for individual risk evaluation to enhance patient outcomes and quality of life.

Journal Article by Wu Z, Shang G (…) Lin R et 3 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Improved Skill Transfer with 3D-Printed Model for Laparoscopic Biliary-Enteric Anastomosis Training

A randomized controlled trial found that training with a 3D-printed model for laparoscopic biliary-enteric anastomosis led to significantly shorter operation times, higher performance scores, and greater goal achievement compared to traditional training methods. This suggests improved skill acquisition and transferability to a clinical setting with the novel simulation model.

Randomized Controlled Trial by Shen J, Zhang Y (…) Yang J et 5 al. in Int J Surg

Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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Advancements in Minimally Invasive Surgical Techniques for Early Gastric Cancer

Minimally invasive surgical techniques, such as endoscopic mucosal resection and laparoscopic and endoscopic cooperative surgery, offer precise and effective options for treating early gastric cancer. These advanced procedures result in less trauma, blood loss, and quicker recovery for patients, providing unique value in the examination and treatment of this condition.

Review by Li CY, Wang YF, Luo LK and Yang XJ in World J Gastrointest Oncol

©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.

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Direct Percutaneous Endoscopic Jejunostomy Tube Placement: A Safer Alternative

Direct percutaneous endoscopic jejunostomy (DPEJ) is a safe and effective alternative to surgical jejunostomy, with lower rates of adverse events at 90 days. Procedural success rates were similar among DPEJ, laparoscopic jejunostomy, and open jejunostomy, but DPEJ had significantly lower rates of tube dysfunction. DPEJ may offer a cost-effective and less invasive option for enteral feeding access in eligible patients.

Journal Article by Locke J, Norwood DA (…) Peter S et 6 al. in Gastrointest Endosc

Copyright © 2023 American Society for Gastrointestinal Endoscopy. All rights reserved.

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Incisional Wound Irrigation with Antiseptic Solutions Reduces Surgical Site Infections

Researchers found that using antiseptic solutions for prophylactic intraoperative incisional wound irrigation significantly reduced surgical site infections (SSIs). In this systematic review and network meta-analysis involving 41 randomized clinical trials with 17,188 patients, antiseptic solutions showed a 40% relative risk reduction in SSIs compared to no irrigation. Antibiotic solutions also reduced SSIs but with lower certainty of evidence. Saline irrigation did not significantly impact SSIs. The study suggests avoiding antibiotic irrigation due to global antimicrobial resistance concerns and recommends antiseptic solutions to reduce SSIs.

Journal Article by Groenen H, Bontekoning N (…) Boermeester MA et 15 al. in JAMA Surg

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Plastic Wound Protectors Significantly Reduce Surgical Site Infections in Open GI Surgery

Researchers found that using a dual-ring plastic wound protector during open gastrointestinal surgery significantly reduced the rate of surgical site infections (SSIs) compared to conventional surgical gauze. In this randomized clinical trial with 457 patients, the SSI rate for the wound protector group was 10.9% versus 20.5% for the gauze group, resulting in a relative risk reduction of 46.81%. The reduction was particularly notable for clean-contaminated wounds and superficial SSIs. Hospital stays and overall complication rates were similar between the two groups.

Journal Article by Yoo N, Mun JY (…) Kim HJ et 11 al. in JAMA Surg

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Interval Appendectomy After Antibiotic Treatment for Appendicitis: Is It Necessary?

Researchers discuss the pros and cons of interval appendectomy for patients who have recovered from acute uncomplicated appendicitis after successful antibiotic treatment. Although surgery has traditionally been the standard treatment, recent data suggest that antibiotics are a safe alternative. However, the high rate of recurrent appendicitis (35-50% at 5 years) has led to a debate about whether interval appendectomy should be offered to reduce future risks. The viewpoint suggests offering interval appendectomy in select cases, weighing factors such as patient age, recurrence risk, and potential complications.

Journal Article by Moris D and Pappas T in JAMA Surg

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Reevaluating Interval Appendectomy After Successful Antibiotic Treatment for Appendicitis

Clinicians debate the merits of interval appendectomy for patients who recover from antibiotic treatment for acute uncomplicated appendicitis. Offering this surgery to avoid future appendicitis risks extra costs, disability, and potential complications, even though many patients may never need surgery. Major clinical trials show high rates of negative pathology among interval appendectomies, suggesting surgery is often unnecessary. Despite antibiotic treatment’s success, many patients have a low risk of recurrence and need to be informed about risks and benefits for shared decision-making.

Journal Article by Talan DA and Minneci PC in JAMA Surg

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Effectiveness of Negative Pressure Wound Therapy in Reducing SSIs after CRS/HIPEC

Researchers found that negative pressure wound therapy (NPWT) can significantly reduce surgical site infections (SSIs) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). A study of 178 patients showed lower SSI rates with NPWT (5.6%) compared to standard surgical dressing (11.4%). Multivariate analysis confirmed that NPWT was associated with a significantly lower risk of developing SSIs (odds ratio 0.24 [0.06, 0.92], p = 0.037). These results suggest that NPWT could be beneficial in reducing SSIs after CRS/HIPEC.

Journal Article by Nabata KJ, Rai S (…) Hamilton TD et 2 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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