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The Role of Adipose Tissue Mesenchymal Stem Cells in Preventing Anastomotic Leak in Colonic Surgery

Adipose tissue-derived mesenchymal stem cells (ADMSCs) were investigated for their potential in reducing inflammation and preventing anastomotic leak in rats with inflammatory bowel disease. Rats were divided into four groups, and those with induced intestinal inflammation were treated with ADMSCs prior to surgery. The study found that ADMSCs effectively attenuated inflammation and significantly reduced the occurrence of anastomotic leak. These findings suggest that ADMSCs could be a promising therapeutic approach for improving colonic anastomosis healing in patients with inflammatory bowel disease.

Journal Article by Ntampakis G, Pramateftakis MG (…) Aggelopoulos S et 9 al. in J Clin Med

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Defining Success in Colorectal Peritoneal Metastasis Surgery: International Consensus and Improved Survival

An international consensus has been reached on the definition of textbook oncologic outcomes (TOO) in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastasis. The TOO parameters for CRS/HIPEC in this context include absence of certain complications, achievement of complete cytoreduction, and no contraindications for chemotherapy. A study cohort of 251 patients showed that patients who met TOO criteria had significantly better overall survival and disease-free survival compared to those who did not. Achievement of TOO as defined by consensus is associated with improved survival.

Journal Article by Zohar N, Nevler A (…) Bowne WB et 6 al. in J Am Coll Surg

Copyright © 2023 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

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Robotic Resection for Perihilar Cholangiocarcinoma Shows Promising Short-term Outcomes

Robotic resection for perihilar cholangiocarcinoma is a safe and feasible approach with acceptable short-term clinical and oncological outcomes. In a multicenter study of 38 patients, the majority had Klatskin type-3 tumors. The median age was 72 years, and most patients underwent preoperative biliary drainage. The procedure had a median operative time of 481 minutes and 82% achieved R0 resection margins. Complications occurred in 16% of patients, and the median length of stay was 6 days. With a median follow-up of 15 months, 68% of patients were alive without disease, 13% had recurrence, and 19% died.

Journal Article by Sucandy I, Marques HP (…) DiBenedetto F et 6 al. in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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Combined use of tumor markers improves prognostic accuracy in gastric cancer

This study evaluated the combined use of three tumor markers (CEA, CA72-4, and CA19-9) for prognostic assessment in gastric cancer patients. Data from 1,966 patients who underwent curative gastrectomy were analyzed, and hazard ratios were calculated. The results showed that the combined use of tumor markers significantly improved prognostic accuracy compared to using a single marker. The survival prediction model incorporating the combined tumor markers proved accurate and effective, indicating its potential as a practical prognostic tool for clinicians.

Journal Article by Zhang R, Chen X (…) Chen Y et 6 al. in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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Drug Response Heterogeneity Found in Patients Undergoing CRS/HIPEC for Nongynecologic Cancers

Among patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for nongynecologic cancers, intra- and interpatient drug response heterogeneity was observed. Researchers generated patient-derived tumor organoids (PDTOs) and conducted in vitro drug screens to assess drug response. PDTOs were successfully generated from 13 out of 23 patients, and drug screen results were obtained in as few as 7 days. The study revealed varying drug sensitivities among tumor types and multiple drug-resistant or pan-sensitive PDTOs. Intrapatient drug response heterogeneity was also observed in patients with organoids generated from multiple metastatic sites.

Journal Article by Radomski SN, Dunworth M (…) Ewald AJ et 3 al. in Ann Surg Oncol

© 2024. Society of Surgical Oncology.

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Perioperative Chemotherapy Linked to Superior Overall Survival in Patients with Colorectal Liver Metastases

Perioperative chemotherapy is associated with superior overall survival in patients with synchronous colorectal liver metastases. Resection of both the primary and metastatic sites is linked to better overall survival. The study also found that patients who received perioperative chemotherapy had significantly longer overall survival compared to those who had preoperative or postoperative chemotherapy alone. Additionally, patients who underwent resection without chemotherapy had shorter overall survival. The findings support a treatment approach with resection and peri- or preoperative systemic therapy for patients with colorectal liver metastases.

Journal Article by Sarkar J, Attwood K and Schwarz RE in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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Optimal surgical techniques and accumulation of cases lead to improved outcomes in robotic pancreaticoduodenectomy

Researchers from a Japanese single center experience studied 76 cases of robotic pancreaticoduodenectomy (RPD) and found that the mean operation time decreased over time despite the involvement of new surgeons. They also observed a decrease in major complications from the early competency phase to the mastery phase. Additionally, optimization of the procedure, specifically the hanging maneuver of the retropancreatic tissue, proved effective in reducing operation time and educating new RPD surgeons. These findings highlight the importance of surgical experience and technique refinement in enhancing RPD outcomes.

Journal Article by Mizumoto T, Takahara T (…) Suda K et 7 al. in Surg Endosc

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Comparison of Short-Term Outcomes of Esophagojejunal Anastomotic Techniques during Laparoscopic Total Gastrectomy

Based on a network meta-analysis of 20 studies involving 3,177 patients, the study found that different esophagojejunal anastomotic techniques during laparoscopic total gastrectomy (LTG) for gastric cancer have comparable rates of anastomotic leakage and stenosis. No significant differences were observed in anastomotic bleeding, operative time, time to soft diet resumption, pulmonary complications, hospital length of stay, and 30-day mortality. However, the functional end-to-end anastomosis technique showed a reduced operative time compared to others. Surgeon preference remains a determining factor when choosing the appropriate technique.

Review by Aiolfi A, Sozzi A (…) Bona D et 5 al. in Surg Endosc

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Laparoscopic Splenectomy Reduces Hepatocellular Carcinoma Risk in Cirrhotic Patients

In this study, 383 patients with hepatitis B virus-related cirrhotic portal hypertension were followed up for 11 years to investigate the impact of laparoscopic splenectomy and azygoportal disconnection (LSD) on hepatocellular carcinoma (HCC) risk. The LSD group demonstrated higher survival rates and lower incidence of HCC compared to the endoscopic therapy group. Logistic regression analysis confirmed that LSD was an independent protective factor against HCC. These findings suggest that LSD can improve postoperative survival and prevent HCC in patients, making it a valuable alternative to liver transplantation in the context of donor shortages.

Journal Article by Gao TM, Xiao KQ (…) Jiang GQ et 7 al. in Surg Endosc

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Endoscopic Intervention Highly Effective and Safe for Gastric Band Erosion

Researchers conducted a systematic review and meta-analysis to evaluate the role of endoscopic removal in treating eroded gastric bands. The analysis included ten studies with a total of 282 patients. The results showed that endoscopic intervention was highly effective and safe for managing gastric band erosion. The average patient age was 40.68 years with an average band placement duration of 38.49 months. This study confirms that endoscopic intervention is a minimally invasive and successful treatment option for gastric band erosion.

Journal Article by Deshmukh A, Desai PM (…) Bazarbashi AN et 5 al. in Obes Surg

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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