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No Significant Benefit of Omental Pedicled Flap in Preventing Anastomotic Leak After Rectal Cancer Surgery

Researchers assessed the impact of omental pedicled flap (OPF) on anastomotic leak in patients undergoing low anterior resection for rectal cancer. Out of the 853 patients included in the study, OPF was utilized in 12.4% of cases. The analysis revealed that OPF use did not affect the occurrence of anastomotic leaks or operative blood loss. However, it was associated with a longer operative duration. Consequently, OPF did not demonstrate any significant benefit in preventing anastomotic leak in this cohort of patients.

Journal Article by Ali D, Syed M (…) Khan A et 7 al. in J Surg Oncol

© 2023 Wiley Periodicals LLC.

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Predictive Factors for Early Recurrence in Metastatic Colorectal Cancer Treated with Combined Liver Resection and HIPEC

The study aimed to identify predictive factors for early recurrence and survival outcomes in colorectal cancer patients with liver and peritoneal metastases who underwent combined liver resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy. The results showed that patients with advanced primary tumors (PT4 and/or PN2 status) had a higher risk of early recurrence, while retroperitoneal lymph node metastasis was associated with poor overall survival. These findings can help improve patient selection and guide treatment strategies for this specific group of patients.

Journal Article by Grange R, Rousset P (…) Kepenekian V et 7 al. in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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Surgical Management Guidelines for Gastrointestinal Neuroendocrine Neoplasms Provide Individualized Approach

Surgical oncologists face the challenge of managing gastrointestinal midgut neuroendocrine neoplasms (NENs), particularly neuroendocrine tumors (NETs). While guidelines offer valuable insights, they rely on expert opinions and retrospective evidence. This review outlines recent recommendations for managing midgut NETs, emphasizing the need for individualized approaches based on tumor behavior, endocrine syndrome association, and prognosis. Staying updated on evolving therapies and tumor understanding is crucial for optimal patient care.

Journal Article by Hallet J and Clarke CN in Ann Surg Oncol

© 2023. Society of Surgical Oncology.

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Higher State Trauma Funding Reduces In-Hospital Mortality among Injured Patients

Increased state trauma funding is associated with a lower risk of in-hospital mortality among injured adult patients. The study analyzed data from 17 states and found that patients in states with more than $1.00 per capita state trauma funding had a 0.82 decreased adjusted odds of in-hospital mortality compared to those in states with less funding.

Journal Article by Byskosh A, Shi M (…) Stey AM et 5 al. in Am J Surg

Copyright © 2023 Elsevier Inc. All rights reserved.

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Bariatric Surgery Facilitates Renal Transplantation in Patients with End-Stage Renal Disease and Obesity

Bariatric surgery (BS) can be a beneficial intervention for patients with obesity and end-stage renal disease (ESRD) who require renal transplantation (RT). A review of 31 patients referred for BS found that those who underwent the procedure had increased access to RT and experienced safe and effective outcomes. These findings suggest that the use of BS in specialized units should be considered for patients with obesity and ESRD.

Journal Article by Bosch KD, Harrington C (…) Parmar C et 7 al. in Obes Surg

© 2024. Crown.

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Metformin Boosts Gemcitabine Response in Cholangiocarcinoma: Targeting PKM2 for Enhanced Apoptosis

Metformin and gemcitabine have a synergistic effect in inhibiting cholangiocarcinoma cell viability, migration, and invasion while promoting apoptosis. In vivo, the combination of metformin and gemcitabine inhibits the growth of cholangiocarcinoma cell-derived tumors. The study suggests that metformin enhances the response of cholangiocarcinoma cells to gemcitabine by suppressing pyruvate kinase M2 (PKM2) and activating mitochondrial apoptosis. This finding provides a promising approach for improving chemotherapeutic sensitivity in cholangiocarcinoma treatment.

Journal Article by Deng H, Qian X (…) Yang P et 2 al. in Dig Dis Sci

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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No Microsatellite Instability in Pancreatic Adenocarcinoma: Correlations with Prognostic Parameters

The study aimed to assess the relationship between DNA mismatch repair (MMR) proteins and prognostic parameters in pancreatic adenocarcinoma. No errors were found in MMR proteins, indicating microsatellite stability. Significant correlations were observed between patient age, tumor diameter, surgical margins, vascular invasion, and survival. Although microsatellite instability was not detected, the study suggests the importance of determining microsatellite status for predicting chemotherapy response and choosing immunotherapy options in pancreatic adenocarcinoma.

Journal Article by Urganci N, Kepil N, Ergun S and Bakkaloglu OK in J Surg Oncol

© 2024 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.

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Safety and Efficacy of Robotic Distal Gastrectomy for Gastric Cancer in Japan

Real-world evidence from a large-scale database in Japan shows that robotic distal gastrectomy (RDG) for gastric cancer is safe and effective. RDG has comparable in-hospital mortality and postoperative complication rates to laparoscopic distal gastrectomy (LDG), but RDG is associated with a longer duration of anesthesia, similar time to diet resumption, and shorter postoperative length of stay. Since becoming insured, RDG has provided shorter postoperative length of stay compared to LDG.

Journal Article by Hondo N, Yamamoto Y (…) Soejima Y et 7 al. in J Surg Oncol

© 2024 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.

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Minimally Invasive Gastrectomy A Safe Alternative to Open Gastrectomy for Advanced Gastric Cancer in Western Countries

Minimally invasive gastrectomy (MIG) shows comparable postoperative recovery, oncological outcomes, and quality of life to open gastrectomy (OG) in patients with advanced gastric cancer in Western countries. A pooled analysis of two European randomized controlled trials found MIG to be a safe alternative to OG, with MIG showing lower blood loss but longer surgery duration compared to OG. This study suggests that the positive outcomes seen with MIG in Asian countries can also be extrapolated to Western populations with advanced gastric cancer.

Journal Article by van der Wielen N, Brenkman H (…) van Hillegersberg R et 6 al. in J Surg Oncol

© 2024 The Authors. Journal of Surgical Oncology published by Wiley Periodicals LLC.

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A Proposed Clinical Synoptic Operative Report Improves Documentation of Ileocolic Resection for Crohn’s Disease

Researchers conducted a retrospective analysis of 66 ileocolic resections (ICR) in 63 Crohn’s disease patients to evaluate the completeness of operative reports. They found that crucial information, such as the examination of bowel for macroscopic disease and the extent of mesenteric resection, was often poorly documented in standard operative reports. However, the proposed clinical synoptic operative report, presented and approved through a consensus process, achieved 100% compliance in recording essential clinical sections. This study highlights the need for standardized reporting to improve future management and research outcomes for Crohn’s patients.

Journal Article by Ng ZQ, Mackenzie S (…) Gibson K et 2 al. in ANZ J Surg

© 2024 The Authors. ANZ Journal of Surgery published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Surgeons.

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