Blog

Circulating Tumor DNA Predicts Recurrence in Pancreatic Cancer

Preoperative and postoperative circulating tumor DNA (ctDNA) are crucial for predicting outcomes in pancreatic cancer patients undergoing surgery.

  • Preoperative ctDNA presence linked to 2.08-fold higher risk of disease-free survival (DFS) and 2.31-fold increased risk of overall survival (OS).
  • Postoperative positivity raises the risk of DFS by 3.29 times and OS by 3.42 times.

Monitoring ctDNA can refine patient selection for neoadjuvant, surgical, and adjuvant therapies, enhancing personalized treatment strategies.

Journal Article by Borges FC, Pinto MS (…) Büchler MW et 11 al. in Ann Surg

Copyright © 2026 The Author(s). Published by Wolters Kluwer Health, Inc.

read the whole article in Ann Surg

open it in PubMed

Improving Surgical Decision-Making for Dementia Patients

Surgeons must navigate the complex landscape of surgical decision-making for patients with dementia, emphasizing informed choices and collaboration.

  • 28 recommendations were developed, with 25 deemed critically important but feasible only in the long-term.
  • Consensus among 23 stakeholders highlighted the need for better resources and team-based care for surgical candidates with cognitive impairment.

Prioritize education on dementia in surgical practice to enhance outcomes and effectively support patients and families.

  • All 21 research priorities gained high consensus, guiding future studies crucial for improving surgical strategies.

Journal Article by Adler RR, Shah SK (…) Traeger L et 12 al. in Ann Surg

Copyright © 2026 Wolters Kluwer Health, Inc. All rights reserved.

read the whole article in Ann Surg

open it in PubMed

Elective Surgery Waitlists Linked to High Emergency Admissions

Patients awaiting elective procedures are facing significant emergency hospital admissions, highlighting a need for timely surgical interventions.

  • Over 33 million waiting days led to 69,322 emergency admissions, using 535,806 bed days.
  • Highest emergency admission rates were for urinary stent procedures (0.71) and endoscopic retrograde cholangiopancreatography (0.63).

Surgeons should prioritize timely treatment to reduce patient risks and alleviate emergency care burdens.

  • Nine procedures experienced more emergency bed days than elective days post-treatment, notably ureteric stones (4.59 ratio).

Observational Study by James AP, Gray WK (…) Lansdown M et 2 al. in Br J Surg

© The Author(s) 2026. Published by Oxford University Press on behalf of BJS Foundation Ltd. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

read the whole article in Br J Surg

open it in PubMed

Multimodal Prehabilitation Shows Limited Impact on Surgery

Multimodal prehabilitation didn’t significantly reduce complications or hospital stays for elective surgery patients, suggesting a need for focused patient selection.

  • Among 4,131 patients, no difference in complications (adjusted risk ratio 1.02) or hospital stay (adjusted ratio 1.04) was found between standard care and prehabilitation.
  • In high-risk gastrointestinal surgery patients, complication risk was 9% lower but not statistically significant (adjusted risk ratio 0.91).

Consider targeting high-risk patients for prehabilitation to better assess its effectiveness in improving surgical outcomes.

Journal Article by Drager LD, Atsma F (…) van den Heuvel B et 8 al. in Br J Surg

© The Author(s) 2026. Published by Oxford University Press on behalf of BJS Foundation Ltd.

read the whole article in Br J Surg

open it in PubMed

Medicare Advantage Limits Access for Surgical Specialists

Medicare Advantage plans often limit patient access to surgical specialists, which can affect care delivery and outcomes.

  • Among 36,584 counties, the average Medicare Advantage network included only 57.6% of surgical specialists.
  • Plastic surgery networks had the least access, averaging 47.1%, while vascular, thoracic, and orthopedic networks exceeded 60%.
  • Over 1 million enrollees reside in counties with no in-network surgeons, particularly in rural areas.

Surgeons should consider these access gaps when evaluating care options for Medicare Advantage patients, especially in underserved regions.

Journal Article by Meiselbach M, Lugo E and Jain A in J Am Coll Surg

Copyright © 2026 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

read the whole article in J Am Coll Surg

open it in PubMed

Drug Strategies to Prevent Delirium in Older Surgical Patients

Dexmedetomidine is a standout option for preventing postoperative delirium in older adults.

  • Overall delirium risk post-surgery is 14.5%.
  • Dexmedetomidine shows a significant reduction (odds ratio 0.46) in delirium risk.
  • Corticosteroids also reduce delirium severity but do not affect other outcomes like length of stay or mortality.

Be cautious with dexmedetomidine due to potential hypotension and bradycardia. Aim for a balanced approach in drug selection for your surgical patients over 60.

  • Other options like melatonin receptor agonists and intranasal insulin show promise but need further validation.

Meta-Analysis by Luney M, Holdsworth L (…) Costa M et 7 al. in BMJ

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. No commercial re-use. See rights and permissions. Published by BMJ.

read the whole article in BMJ

open it in PubMed

New Insights on Long-Term Outcomes in Ventral Hernia Repairs

A recent study shows that claims-based coding effectively tracks long-term complications after ventral hernia repair.

  • Cumulative incidence of non-recurrence procedural intervention is 7.17% using claims data, compared to 5.54% with electronic health records.
  • Reoperation for recurrence shows similar results: 6.84% for claims versus 7.00% for EHR.

This coding method improves follow-up accuracy, aiding in patient selection and surgical decision-making.

  • The study analyzed 1,229 patients over 4.5 years, emphasizing its potential for research and quality improvement initiatives.

Journal Article by Kenawy DM, Underhill JM (…) Poulose BK et 5 al. in Ann Surg

Copyright © 2026 Wolters Kluwer Health, Inc. All rights reserved.

read the whole article in Ann Surg

open it in PubMed

Chronic Immunosuppression Elevates Risks in Emergency Surgery

Patients on chronic immunosuppression face higher mortality after emergency surgery, especially with complex procedures.

  • 5.1% of over 30,000 patients studied were on chronic immunosuppression, showing a 2.3% higher mortality risk (p<0.001).
  • Increased complications, infections, and readmission rates were also observed for this group.

Surgeons should be cautious with emergency exploratory laparotomy in these patients while simpler procedures like appendectomy can be performed safely.

  • No mortality risk increase was noted for appendectomy, cholecystectomy, or small bowel obstruction surgeries.

Journal Article by Levy SC, Johnson PL (…) Hemmila MR et 3 al. in J Am Coll Surg

Copyright © 2026 by the American College of Surgeons. Published by Wolters Kluwer Health, Inc. All rights reserved.

read the whole article in J Am Coll Surg

open it in PubMed

New strategies for managing cancer-related intestinal obstruction

Cancer-related incomplete intestinal obstruction complicates treatment in advanced malignancy patients.

  • Recent techniques such as endoscopic stenting and laparoscopic surgery show improved outcomes and lower complication rates.
  • Integration of systemic therapies like immunotherapy reduces tumor burden and alleviates obstruction.

Multidisciplinary approaches remain vital for individualizing patient care and optimizing recovery.

  • Nutritional support and fluid management are essential in symptom management.

Editorial by Liu JL, Wang CX and Wang HL in World J Gastroenterol

©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.

read the whole article in World J Gastroenterol

open it in PubMed

Mentorship Improves Early-Career Success in Surgery

A structured mentoring committee significantly enhances academic trajectories for early-career surgeons.

  • After 8 years, 58 mentees rated the program highly, with 94% finding the information valuable.
  • 90% felt the meetings contributed to their academic success and 88% appreciated the communication following sessions.

Implementing formal mentoring in surgical departments can lead to better faculty development and retention.

  • PhD mentees rated the meeting time lower than MD counterparts, indicating room for improvement in program structure.

Journal Article by Leonard SP, Redlich PN (…) Evans DB et 6 al. in BMC Surg

Copyright © 2025 Elsevier Inc. All rights reserved.

read the whole article in BMC Surg

open it in PubMed