Surgeons need to consider how perioperative quality of life fluctuates in pancreatic cancer patients to enhance outcomes.

• Quality of life scores significantly change between perioperative stages (p < 0.001).
• Main issues needing attention: pain and nausea in the first week, social functioning before discharge, and fatigue one month post-op.

Timely interventions on these factors can improve care and patient well-being.

• 66.79% of patients had ductal adenocarcinoma, indicating a majority skew in disease type affecting recovery profiles.

Surgical resection significantly enhances survival in borderline resectable and locally advanced pancreatic cancer compared to continued oncology therapy.

• Median overall survival (OS) is 39.0 months after resection versus 16.7 months with oncology therapy (p < 0.0001).
• In a matched cohort, OS is 42.6 months with resection compared to 18.6 months with oncology therapy (p < 0.0001).

Selecting patients with favorable chemotherapy responses for surgery can lead to better outcomes.

• Resection remains advantageous even with postoperative mortality included in the analysis.

This study shows that using a stapler for pancreatic transection in robot-assisted pancreaticoduodenectomy reduces clinically relevant postoperative pancreatic fistulas.

• The stapler method group had a cr-popf incidence of 13.1% compared to 31.5% in the conventional group (p=0.014).
• Body mass index is a risk factor for cr-popf (OR 1.34), while the stapler method reduced risk (OR 0.31).

Surgeons should consider the stapler method to improve postoperative outcomes without increasing complication rates.

• Postoperative amylase levels were higher with the stapler method, but acute pancreatitis rates were similar (1.6% vs. 1.4%).

Non-benchmark patients with perihilar cholangiocarcinoma can achieve good outcomes despite higher complexity.

• 64% of 648 patients analyzed were classified as non-benchmark, with median overall survival at 46 months.
• Postoperative liver failure occurred in 16.7%, bile leakage in 22.8%, and in-hospital mortality was 2.9%, all within benchmark limits.

Choose treatment strategies carefully: complexity impacts survival significantly, with 5-year rates dropping from 50.5% in medical only to 15.4% in dual patients.

• Left trisectionectomy had the highest mortality rate at 9.5%.