Surgeons need to tackle failure to rescue (FTR) after hepatectomy to enhance patient outcomes.

• FTR, linked to complications like liver failure and sepsis, remains a critical issue despite better surgical techniques.
• Higher surgical volumes correlate with lower FTR rates; experienced teams and quick interventions are key.

Proactive strategies, including preoperative optimization and better surveillance, can significantly improve survival.

• Future tech like predictive analytics and AI could aid in early complication detection.

Next-generation sequencing identifies actionable targets in biliary tract cancer, changing treatment for fit patients.

• Roughly 50% of biliary tract cancer patients have actionable genomic alterations, especially in intrahepatic cholangiocarcinoma.
• Targeted therapies are showing clinical benefits and manageable safety profiles over standard treatments.

Surgeons should consider incorporating molecular profiling into patient assessments to optimize postoperative therapy options.

• Future strategies aim to address treatment resistance and better integrate targeted drugs into treatment pathways.

Laparoscopic enucleation is a safe, efficient option for large benign or low-grade malignant pancreatic tumors.

• No difference in perioperative complications between large and small tumor patients undergoing laparoscopic enucleation.
• Laparoscopic enucleation significantly reduces operative time (160 vs. 397 minutes) compared to standard pancreatectomy procedures.

Surgeons may consider laparoscopic enucleation to optimize surgical outcomes without increasing risks in larger tumor cases.

ECVF from contrast-enhanced CT can predict postoperative pancreatic fistula risk.

• In a study of 71 patients post-pancreatic resection, ECVF correlated with pancreatic fibrosis.
• An ECVF of less than 36% linked to increased risk of pancreatic fistula.

Understanding ECVF helps in patient selection and surgical decision-making.

• ECVF also indicates acinar loss and overall pancreatic histology.