Indocyanine Green (ICG) fluorescence in laparoscopic subtotal gastrectomy for gastric cancer showed a sensitivity of 75.86% in detecting metastatic lymph nodes and 90.7% in identifying them. ICG-guided lymphadenectomy revealed higher fluorescent lymph node numbers in patients with metastases. The method offers high negative predictive value and clear visualization of the lymphatic system, indicating effectiveness in […]
Author: STITCHES Newsletter
Factors associated with loss to follow-up in surgical trials
Loss to follow-up (LTFU) is uncommon in surgical randomized controlled trials. Characteristics associated with reduced LTFU include standard-of-care outcome assessments, surgery for transplantation or cancer. Increased LTFU risk is seen in trials with patient-reported outcomes and longer follow-up periods. Understanding these factors can help investigators anticipate and address LTFU to ensure trial integrity. Journal Article […]
Sex Differences in Weight Loss and Complications Post Bariatric Surgery
Male patients had slightly greater weight loss and higher complication rates compared to females following bariatric surgery. However, these differences were not clinically significant. Providers should consider referring males earlier for surgery given their higher comorbidity rates. This study highlights the need to assess sex differences in outcomes to personalize bariatric care effectively. Journal Article […]
Filgotinib 200 mg Shows Efficacy in Perianal Fistulising Crohn’s Disease
Filgotinib 200 mg demonstrated efficacy in treating perianal fistulising Crohn’s disease, with a higher proportion of participants achieving a combined fistula response compared to lower doses and placebo. Serious adverse events were more frequent with the 200 mg dose, but no treatment-related serious adverse events or deaths were reported. Filgotinib 200 mg was generally well […]
High Rates of Colitis-Associated Post-Colonoscopy Colorectal Cancers
Analysis reveals 61% of inflammatory bowel disease-related colorectal cancers were post-colonoscopy, often due to delays in surveillance and missed lesions in areas of inflammation. Proactive strategies are needed to reduce endoscopic burden and improve surveillance adherence, as traditional methods show limitations in detecting aggressive cancer evolution. Molecular biomarkers may enhance risk assessment in future clinical […]
Development of Gallstone Recurrence Prediction Model
A nomogram model was developed to predict gallstone recurrence after gallbladder-preserving surgery based on identified risk factors. Factors such as gallstone duration, symptoms, number of stones, cholecystitis history, and diet were significant predictors. The nomogram showed good predictive value (c-index = 0.692). Clinicians can utilize this model to strategize treatment for gallstone patients, suggesting caution […]
Improved Surgical Outcomes with Thoracic Duct Visualization
Patent blue injection enhances intraoperative thoracic duct visualization during esophagectomy. In a pilot trial, the duct was visualized in 60% of patients, leading to significantly shorter operative times, fewer complications, and shorter hospital stays compared to controls. Although chyle leak rates did not significantly differ, this simple method shows promise for improving surgical outcomes in […]
Optimal Proximal Margin Length Improves Prognosis in Adenocarcinoma of Gastroesophageal Junction
Study finds proximal margin length ≥1.2 cm linked to improved outcomes in Siewert II/III adenocarcinoma of esophagogastric junction, lowering risk of disease progression. This offers valuable guidance for surgical decision-making and enhances patient outcomes, particularly for subgroups with specific tumor characteristics. These findings emphasize the importance of optimal proximal margin length in surgical approaches for […]
Improved Survival Prediction in Intrahepatic Cholangiocarcinoma
Preoperative CT radiomics of intrahepatic cholangiocarcinoma and peritumoral tissue enhances survival prediction. Combined with clinical data, the radiomic model achieves equivalent prognostic estimates compared to postoperative pathology. In a study of 215 patients, the addition of radiomic features led to a significant improvement in overall and progression-free survival predictions. Consideration of both portal and arterial […]
Combination Therapy Improves Survival in Early-Onset Pancreatic Cancer
Study on non-metastatic early-onset pancreatic cancer patients showed postoperative survival improvement with adjuvant therapy. Surgery followed by neoadjuvant and adjuvant therapy recommended for locally advanced cases. 1-year, 2-year, and 3-year overall survival rates were 84.3%, 51.5%, and 27.6% respectively. Findings suggest a positive impact of combination therapy including surgery, radiotherapy, and chemotherapy on survival outcomes […]