Patients with colon cancer at high risk of recurrence benefit from preoperative evaluation, neoadjuvant chemotherapy, and revised intraoperative strategies. Specialized treatments, including hipec intraoperative chemotherapy, improve outcomes for patients with occult peritoneal metastases. Optimized cytoreductive surgical procedures and peritonectomy reduce sites of metastases, enhancing the effectiveness of colon cancer resection. Review by Sugarbaker PH in […]
Category: Cytoreductive Surgery & Peritoneum
Long-Term Survival Benefits of Surgery with HIPEC for Perforated Low-Grade Appendiceal Mucinous Neoplasms
Study demonstrates that combining surgery with HIPEC significantly improves 5- and 10-year overall survival rates and relapse-free survival of LAMN perforation patients without impacting short-term outcomes. Analysis of 91 patients revealed higher survival rates in the HIPEC group compared to non-HIPEC group, highlighting the potential impact of this combined approach on patient outcomes. Research Support, […]
Effectiveness of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer
A meta-analysis of 16 randomized controlled trials with 1,641 patients assessed the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) for treating and preventing peritoneal carcinomatosis in advanced gastric cancer. Surgery plus HIPEC improved overall survival in both prophylactic (HR 0.56) and therapeutic (HR 0.57) settings, with a 3-year mortality rate of 32% for the prophylactic HIPEC […]
Benefit of Surgical Cytoreduction for Patients with Small Intestinal Neuroendocrine Tumors Metastatic to the Liver and Peritoneum
Complete cytoreduction can significantly improve survival and relieve symptoms in patients with small intestinal neuroendocrine tumors metastatic to the liver and peritoneum. Despite initial controversies, achieving complete cytoreduction yielded comparable outcomes in patients with isolated liver metastases and those with liver and peritoneal metastases. Aggressive surgical cytoreduction should be considered even in the presence of […]
Effectiveness of Negative Pressure Wound Therapy in Reducing SSIs after CRS/HIPEC
Researchers found that negative pressure wound therapy (NPWT) can significantly reduce surgical site infections (SSIs) after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). A study of 178 patients showed lower SSI rates with NPWT (5.6%) compared to standard surgical dressing (11.4%). Multivariate analysis confirmed that NPWT was associated with a significantly lower risk of […]
Improved Detection of Residual Peritoneal Metastases with Pegsitacianine Imaging Agent
Use of pegsitacianine, a pH-sensitive imaging agent, detected residual disease in 50% of patients undergoing cytoreductive surgery. Pegsitacianine showed high sensitivity, improved surgeon assessment, and had acceptable safety profile. This agent has the potential to enhance detection of residual disease and improve outcomes in peritoneal carcinomatosis patients. Journal Article by Wagner P, Levine EA (…) […]
Improved Detection of Residual Peritoneal Metastases with Pegsitacianine Imaging Agent
Use of pegsitacianine, a pH-sensitive imaging agent, detected residual disease in 50% of patients undergoing cytoreductive surgery. Pegsitacianine showed high sensitivity, improved surgeon assessment, and had acceptable safety profile. This agent has the potential to enhance detection of residual disease and improve outcomes in peritoneal carcinomatosis patients. Journal Article by Wagner P, Levine EA (…) […]
Hyperthermic Intraperitoneal Chemotherapy Improves Survival in Gastric Cancer Patients
Hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improved overall survival and reduced recurrence rates in both prophylactic and therapeutic settings for peritoneal carcinomatosis of gastric origin. This systematic review and meta-analysis of randomized trials highlights the efficacy of HIPEC as a safe and effective tool for prophylaxis and a promising resource for treatment, emphasizing the need for […]
Extent of Resection and Long-Term Outcomes for Appendiceal Adenocarcinoma
Mucinous and non-mucinous appendiceal adenocarcinomas exhibit differences in recurrence rates and nodal positivity. Colectomy is associated with improved disease-specific survival for non-mucinous tumors at certain stages and grades, but not for mucinous tumors. This suggests that colectomy may not be necessary for mucinous appendiceal adenocarcinoma patients. Journal Article by Tsagkalidis V, Choe JK (…) Ecker […]
Deep Learning System Outperforms Surgeons in Identifying Peritoneal Surface Metastases
Development and testing of a prototype deep learning surgical guidance system showed improved performance in identifying peritoneal surface metastases compared to oncologic surgeons. The system demonstrated potential for increasing identification of metastases by 5% and reducing unnecessary biopsies by 28% in a simulated clinical environment. Journal Article by Schnelldorfer T, Castro J, Goldar-Najafi A and […]