Use of pegsitacianine, a pH-sensitive imaging agent, detected residual disease in 50% of patients undergoing cytoreductive surgery. Pegsitacianine showed high sensitivity, improved surgeon assessment, and had acceptable safety profile. This agent has the potential to enhance detection of residual disease and improve outcomes in peritoneal carcinomatosis patients. Journal Article by Wagner P, Levine EA (…) […]
Category: Cytoreductive Surgery & Peritoneum
Hyperthermic Intraperitoneal Chemotherapy Improves Survival in Gastric Cancer Patients
Hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improved overall survival and reduced recurrence rates in both prophylactic and therapeutic settings for peritoneal carcinomatosis of gastric origin. This systematic review and meta-analysis of randomized trials highlights the efficacy of HIPEC as a safe and effective tool for prophylaxis and a promising resource for treatment, emphasizing the need for […]
Extent of Resection and Long-Term Outcomes for Appendiceal Adenocarcinoma
Mucinous and non-mucinous appendiceal adenocarcinomas exhibit differences in recurrence rates and nodal positivity. Colectomy is associated with improved disease-specific survival for non-mucinous tumors at certain stages and grades, but not for mucinous tumors. This suggests that colectomy may not be necessary for mucinous appendiceal adenocarcinoma patients. Journal Article by Tsagkalidis V, Choe JK (…) Ecker […]
Deep Learning System Outperforms Surgeons in Identifying Peritoneal Surface Metastases
Development and testing of a prototype deep learning surgical guidance system showed improved performance in identifying peritoneal surface metastases compared to oncologic surgeons. The system demonstrated potential for increasing identification of metastases by 5% and reducing unnecessary biopsies by 28% in a simulated clinical environment. Journal Article by Schnelldorfer T, Castro J, Goldar-Najafi A and […]
Simultaneous Resection of Liver Metastases Combined with HIPEC Improves Clinical Outcomes in Synchronous Colorectal Cancer Liver Metastasis
The study showed that simultaneous resection of liver metastases combined with HIPEC resulted in a significantly higher complete resection rate, total effective rate, and negative change of CEA compared to resection alone. This approach demonstrated superior efficacy in treating synchronous colorectal cancer liver metastases, potentially extending patient survival and improving quality of life. Journal Article […]
Centralization of Cytoreductive Surgery Alone Improves Perioperative Outcomes for Colorectal Peritoneal Metastases
Centralization of cytoreductive surgery alone for colorectal peritoneal metastases improved 90-day postoperative mortality and failure-to-rescue rates. High-volume centers showed lower mortality rates compared to low-volume and no-hipec centers. After the Prodige 7 trial, there was a drastic decrease in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy rates in cancer centers, while patients treated with cytoreductive surgery […]
Histological Growth Pattern Predicts Survival in Peritoneal Metastases
Patients with colorectal peritoneal metastases who underwent cytoreductive surgery had better disease-free and overall survival if they had a dominant pushing histological growth pattern compared to infiltrating pattern. The study confirmed the prognostic value of these patterns regardless of neoadjuvant chemotherapy or extent of peritoneal disease burden. No significant associations were found between neoadjuvant chemotherapy […]
Improved Pain Management and Recovery After Implementation of ERAS Protocol for CRS-HIPEC
Enhanced Recovery After Surgery (ERAS) protocol implementation for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) led to increased epidural use, decreased oral and intravenous opioid requirements, and earlier restoration of bowel function. Patients with epidurals had significantly lower opioid needs post-ERAS, with improved ambulation, diet initiation, and return of bowel function compared to pre-ERAS patients. […]
Improved Odds of Cytoreductive Surgery with HIPEC and Survival for Colorectal Peritoneal Metastases
Findings from a nationwide population-based study revealed that patients diagnosed in hipec centers had better odds of undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) and improved survival rates before 2016. However, after national efforts to increase awareness and improve referral networks, these differences were no longer present between patients diagnosed in hipec and referring […]
Impact of Laparoscopic HIPEC on Safety and Perioperative Outcomes in Gastric Cancer with Peritoneal Metastasis
Laparoscopic HIPEC for gastric cancer with peritoneal metastasis is safe and associated with minimal perioperative complications. Approximately one third of patients undergoing initial laparoscopic HIPEC proceeded to cytoreduction and gastrectomy. Preliminary survival data from this study indicate a median overall survival of 11 months from the initial procedure and 19.3 months from the diagnosis, suggesting […]