In this study, 383 patients with hepatitis B virus-related cirrhotic portal hypertension were followed up for 11 years to investigate the impact of laparoscopic splenectomy and azygoportal disconnection (LSD) on hepatocellular carcinoma (HCC) risk. The LSD group demonstrated higher survival rates and lower incidence of HCC compared to the endoscopic therapy group. Logistic regression analysis […]
Category: HPB & Spleen
Predictive Factors for Early Recurrence in Metastatic Colorectal Cancer Treated with Combined Liver Resection and HIPEC
The study aimed to identify predictive factors for early recurrence and survival outcomes in colorectal cancer patients with liver and peritoneal metastases who underwent combined liver resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy. The results showed that patients with advanced primary tumors (PT4 and/or PN2 status) had a higher risk of early recurrence, while retroperitoneal […]
Metformin Boosts Gemcitabine Response in Cholangiocarcinoma: Targeting PKM2 for Enhanced Apoptosis
Metformin and gemcitabine have a synergistic effect in inhibiting cholangiocarcinoma cell viability, migration, and invasion while promoting apoptosis. In vivo, the combination of metformin and gemcitabine inhibits the growth of cholangiocarcinoma cell-derived tumors. The study suggests that metformin enhances the response of cholangiocarcinoma cells to gemcitabine by suppressing pyruvate kinase M2 (PKM2) and activating mitochondrial […]
No Microsatellite Instability in Pancreatic Adenocarcinoma: Correlations with Prognostic Parameters
The study aimed to assess the relationship between DNA mismatch repair (MMR) proteins and prognostic parameters in pancreatic adenocarcinoma. No errors were found in MMR proteins, indicating microsatellite stability. Significant correlations were observed between patient age, tumor diameter, surgical margins, vascular invasion, and survival. Although microsatellite instability was not detected, the study suggests the importance […]
Impact of Tumor Size on Outcomes of Hepatic Resection for Hepatocellular Carcinoma
The study evaluated the impact of tumor size on perioperative and long-term outcomes of liver resection for hepatocellular carcinoma (HCC). Three groups were categorized based on tumor size. Group III had larger tumors and exhibited higher incidence of unfavorable factors such as multiple tumors, organ invasion, and lymph node presence. Group III also required more […]
Personalized Circulating Tumor DNA Predicts Recurrence in Resectable Pancreatic Cancer
Researchers evaluated the feasibility of using a personalized, tumor-informed circulating tumor DNA (ctDNA) assay to detect recurrence in patients with resectable pancreatic adenocarcinoma (PDAC). They successfully designed ctDNA assays for all patients, and found that ctDNA positivity during the immediate postoperative period was associated with significantly inferior recurrence-free survival and overall survival. This study demonstrates […]
Intra-Abdominal Abscesses After Major Liver Trauma: Unraveling Risk Factors
The study investigated risk factors associated with intra-abdominal abscesses (IAA) following major operative liver trauma. Based on a retrospective multi-center study involving 372 patients, it was found that patients with penetrating trauma, activation of intraoperative massive transfusion protocol, biloma/bile leak, longer hospital length of stay, and additional intra-abdominal injuries had a higher risk of developing […]
Extent of intramucosal involvement in gallbladder adenocarcinoma is a marker for advanced disease and poorer survival.
Patients with diffuse involvement of the gallbladder mucosa have aggressive tumor biology and worse overall survival compared to those with focal disease. This retrospective study analyzed 63 patients with non-metastatic gallbladder adenocarcinoma and found that 50.7% had diffuse cancer. There was no difference in the utilization of definitive surgery between the groups. These findings provide […]
Emergence of Predictive Models and Gallbladder-Preserving Polypectomy Procedures in the Management of Gallbladder Polyps
Researchers have made advances in the management of gallbladder polyps through the establishment of predictive models and the use of gallbladder-preserving polypectomy procedures. These procedures allow for the eradication of lesions while preserving a functional gallbladder, providing benefits to patients with benign polyps. However, further large-scale clinical studies are needed to address limitations such as […]
Predictive Factors for Early Recurrence in Metastatic Colorectal Cancer Treated with Combined Liver Resection and HIPEC
The study aimed to identify predictive factors for early recurrence and survival outcomes in colorectal cancer patients with liver and peritoneal metastases who underwent combined liver resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy. The results showed that patients with advanced primary tumors (PT4 and/or PN2 status) had a higher risk of early recurrence, while retroperitoneal […]