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A retrospective analysis of 111 pancreatic cancer patients undergoing pancreaticoduodenectomy revealed that 62.2% achieved textbook outcomes, significantly improving overall survival (OS) [p=0.03; HR=0.60]. Cox regression identified achievement of these outcomes as a protective factor for OS [p=0.04; HR=4.08]. Key barriers to achieving textbook outcomes included…
Gene expression analysis revealed 236 common differentially expressed genes (DEGs) between COVID-19 and pancreatic cancer (PC) patients. Functional enrichment pointed to pathways linked to viral replication and tumorigenesis. Ten hub genes, including cyclin-dependent kinase 1 and aurora kinase B, were identified, along with 42 transcription…
A novel nomogram, based on liver stiffness (ls) via 2D-sheared wave elastography and spleen area (spa), was developed to predict posthepatectomy liver failure (PHLF) in hepatocellular carcinoma patients. Analysis of 562 patients demonstrated superior diagnostic performance compared to conventional models, such as the MELD and…
In a systematic review of six randomized controlled trials involving 736 patients, the anterior approach with or without liver hanging maneuver demonstrated significant survival benefits over conventional techniques. Overall and disease-free survival rates improved markedly (HR: 0.65; p < 0.0001). Although associated with longer surgery…
The study identified several key prognostic factors impacting unresectable recurrence-free survival (urfs) in colorectal liver-only metastasis patients. Significant predictors included KRAS G12D mutation positivity (HR: 7.69), RYR2 mutation positivity (HR: 4.03), KRAS G12S mutation positivity (HR: 3.96), CA19-9 > 37 U/ml prior to hepatectomy (HR:…
A retrospective analysis of 66,326 patients revealed that 25.3% of pancreaticoduodenectomies (PD) for non-metastatic pancreatic ductal adenocarcinoma were futile, defined as death within 12 months. Factors increasing futility included macroscopically positive margins, poor tumor differentiation, and N2 nodal stage. Conversely, systemic therapy, radiation, and neoadjuvant…
The study details the technical aspects and surgical outcomes of laparoscopic anatomical right hepatectomy using a four-incision anterior approach. Key maneuvers included blocking the glissonean pedicle and ligation of critical vessels, with an emphasis on anatomical landmarks for liver section determination. Successful patient positioning and…
Analysis of 1,137 cases revealed that total hospitalization costs for pancreaticoduodenectomy were notably higher compared to pancreatectomy and hepatectomy within the China Healthcare Security Diagnosis Related Groups system. Length of hospital stay was significantly longer for pancreaticoduodenectomy patients. While the costs of pancreaticoduodenectomy and pancreatectomy…
A study analyzing surgical outcomes for robotic pancreatoduodenectomy (RPD) found that a surgeon with extensive laparoscopic pancreatoduodenectomy (LPD) experience can successfully navigate the RPD learning curve. Performance metrics indicated that operation times significantly decreased in the proficiency phase, starting from case 34, without increasing complications…
Early postoperative CT imaging after pancreatectomy significantly improved patient outcomes. Among 370 patients studied, those receiving early scans had shorter hospital stays (17.05 days vs. 22.82 days, p = .0008) and lower mortality rates (0% vs. 11%, p = .02). Early imaging also emerged as…
