Delving into the ideal moment for post-pancreatic adenocarcinoma surgery chemotherapy, a simulated trial tracked 1491 patients. Noteworthy findings revealed a median survival of 29.9 months for late initiators (>4-8 weeks) versus 30.4 months for early starters (0-4 weeks). Encouragingly, delaying treatment up to 8 weeks post-surgery showed comparable safety, offering a nuanced approach that respects […]

A systematic scoping review explored the role of intraoperative pancreatoscopy (IOP) in the surgical management of intraductal papillary mucinous neoplasms (IPMN) in the pancreas. IOP allows for the visualization of the main pancreatic duct, aiding in surgical planning. The review of five studies revealed IOP to be safe, detecting additional lesions in 34% of cases […]

This study delves into the impact of surgical approach on the 30-day outcomes of pancreatic cancer patients after neoadjuvant treatment (NAT). Researchers compared minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD) within NAT groups. Among the 5,588 patients analyzed, MIPD after neoadjuvant chemotherapy alone resulted in lower complication rates, shorter hospital stays, and fewer complications […]

For those facing surgery for perihilar cholangiocarcinoma (pcca), concerns about hepatic steatosis and fibrosis were investigated. Analyzing data from 401 patients, researchers found that neither hepatic steatosis nor fibrosis were associated with postoperative outcomes, including posthepatectomy liver failure (phlf) or 90-day mortality. Instead, factors like preoperative cholangitis and liver remnant size proved to be more […]

This systematic review and meta-analysis delved into the world of pancreatic cancer, focusing on frailty. Among 35,191 patients, they discovered that 45% of pancreatic cancer patients were frail. This frailty took a toll, significantly reducing their chances of survival. While the results displayed some variation, they underscored the vital role of assessing frailty in pancreatic […]

Researchers explored the impact of hepatopancreaticoduodenectomy (HPD), a radical surgery for biliary carcinoma, on survival in patients with widespread cancer. Of the 54 patients who underwent HPD, 89% achieved R0 resection, significantly improving survival with a median of 36.9 months. Pathological portal vein involvement was identified as an independent prognostic factor. Those with peripancreatic lymph […]

A study exploring the surgical treatment of resectable pancreatic adenocarcinoma in minority serving hospitals (MSH) revealed significant disparities. Patients at MSH were less likely to undergo surgical resection, facing unique barriers, and leading to increased mortality among those who did. These findings highlight the urgent need for targeted interventions to improve the care provided to […]

A multicenter study harnessed Magnetic Resonance Elastography (MRE) to create a prediction model for hepatic decompensation in Non-Alcoholic Fatty Liver Disease (NAFLD) patients. This model, which combines MRE data with clinical factors like age, albumin, aspartate aminotransferase, and platelets, demonstrated excellent accuracy in forecasting the risk of hepatic decompensation over 3- and 5-year periods. The […]

To enhance the precision of small liver tumor removal, a phase II study in Japan will evaluate preoperative marking’s effectiveness. Patients with liver tumors ≤15 mm requiring hepatectomy will undergo microcoil placement near the tumor using either the percutaneous or transvascular approach. The study aims to determine the successful resection rate, with secondary endpoints including […]