Analysis of 86 patients with hepatocellular carcinoma and portal vein tumor thrombosis showed no significant difference in overall survival and recurrence-free survival between laparoscopic and open liver resections. The only predictors of recurrence-free survival were specific pathological factors, not the type of surgery. Laparoscopic resection for HCC with PVTT provides comparable short- and long-term outcomes […]
Category: HPB & Spleen
Visceral Adipose Tissue Predicts Survival in Resectable Pancreatic Adenocarcinoma
In patients with resectable pancreatic adenocarcinoma, a study analyzed body composition metrics from baseline CT scans in the SWOG S1505 trial. Visceral adipose tissue (VATA) was associated with overall survival, but no significant links were found between survival and sarcopenia or sarcopenic obesity. This prospective multicenter trial revealed novel insights, suggesting a potential role for […]
Prognostic Factors in Solitary Colorectal Liver Metastasis: N2 Stage, Hypoalbuminemia, and Neutrophil-Lymphocyte Ratio
Researchers analyzed data from 230 patients with solitary liver metastases from colorectal cancer undergoing liver resection. They found that initial N2 stage, hypoalbuminemia before surgery, and high neutrophil-to-lymphocyte ratio after surgery were independent prognostic factors for recurrence-free and overall survival. Patients with these factors should receive upfront chemotherapy, prompt postoperative chemotherapy, and intensive postoperative surveillance. […]
Impact of perioperative blood transfusion on survival after curative hepatectomy for hepatocellular carcinoma
Perioperative blood transfusion during curative hepatectomy for hepatocellular carcinoma was associated with a higher incidence of postoperative complications and longer hospitalization, but did not significantly impact overall survival. A total of 846 patients were studied, with 125 receiving transfusions and 720 not. Patients who received blood transfusion had worse disease-free and overall survival rates across […]
Impact of Multibipolar Radiofrequency Ablation on Intrahepatic Cholangiocarcinoma Recurrence
Multibipolar radiofrequency ablation (RFA) resulted in lower local recurrence rates in patients with intrahepatic cholangiocarcinoma (ICCA) compared to monopolar RFA. Treatment-naive patients had a median overall survival of 26 months and tumor size and Child-Pugh B score were associated with higher mortality. Distant recurrence rates were lower for small ICCA tumors. Cirrhotic ICCA patients had […]
Surgeons Exhibit Varied Views on PDAC Resectability, Regardless of Classification System
Surgeons’ classification of pancreatic ductal adenocarcinoma (PDAC) resectability varies significantly, regardless of the adopted classification system, according to a survey distributed to international HPB surgeons. The study found notable discordance among surgeons in determining resectability, with a median concordance rate of 62.5% with their chosen classification system. Overall, the findings highlight the need for standardized […]
Development of a Preoperative Risk Score for Recurrence in Non-Cirrhotic Hepatocellular Carcinoma Patients
Researchers developed a preoperative risk score based on early recurrence to estimate outcomes after liver resection in non-cirrhotic hepatocellular carcinoma patients. By analyzing data from 263 patients, they identified macroscopic vascular invasion, multifocal tumor, and spontaneous tumor rupture as predictors of early recurrence. This score allows for stratification of patients based on recurrence risk assessment, […]
Adverse Impact of Perioperative Blood Transfusions on Pancreatic Cancer Surgery Survival
Researchers investigated perioperative factors influencing survival in pancreatic ductal adenocarcinoma (PDAC) surgery. Analyzing a Danish cohort (2011ā2020), they found that perioperative blood transfusions were linked to significantly shorter overall survival (OS) in resected PDAC patients (HR 2.53, pā=ā0.005), with a marked difference at 72 months post-surgery. No significant associations were observed for surgery duration or […]
Absence of a pancreatic microbiome in intraductal papillary mucinous neoplasm: a study on microbial presence and diversity
Researchers analysed 338 cyst fluid samples from 190 IPMN patients and found no significant difference in microbiome signatures compared to negative controls. In patients who recently had invasive procedures, a gut-associated microbe outlier signal was evident. The study concluded that IPMNs and pancreatic cystic neoplasms do not have a distinct microbiome, supporting the concept of […]
Benchmarking Report Guides Infection and Antibiotic Control in Pediatric Appendicitis
Complete liver splitting along the demarcation line induced higher portal vein pressure and more rapid future liver remnant hypertrophy than partial or ectopic liver splitting after portal vein ligation in a rat model. The portal hemodynamic alterations, rather than inflammatory cytokine release, played a significant role in accelerating liver hypertrophy. Extrahepatic organ injury, such as […]