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Postoperative complications in high-risk surgical populations increase mortality, disability, and costs. BIGPROMISE cohort profile discusses rationale and scope to investigate risk factors and outcomes related to postoperative complications. Over 3000 adult patients undergoing major surgery contribute data and biomarkers for analysis. With a focus on…
Patients in regions with poorer food environments exhibit higher odds of late-stage gastrointestinal cancer diagnosis and worse survival rates. These disparities are pronounced across various cancer types, highlighting the need for targeted interventions to mitigate socioeconomic and dietary influences on cancer outcomes.
Postoperative outcomes among patients treated by international medical graduate (IMG) surgeons were comparable to those by United States medical graduate (USMG) surgeons. IMG surgeons had lower rates of adverse postoperative outcomes, such as 90-day readmission and index complications. They were also more likely to care…
Postoperative complications were associated with significantly worse patient-reported outcomes, including lower physical and mental health scores, higher pain interference and fatigue, and lower physical function. A substantial number of patients reported outcomes below national benchmarks, emphasizing the need for improved post-surgical care to enhance patients'…
Among general surgery patients, major bleeding, sepsis, and myocardial injury after non-cardiac surgery (MINS) were independently associated with 30-day mortality. These complications had the largest attributable fraction of post-operative deaths. Findings suggest the need for strategies, such as perioperative bleeding prophylaxis, to reduce mortality in…
Dexmedetomidine significantly decreases postoperative acute kidney injury (AKI) incidence compared to controls (RR 0.60, 95% CI 0.45-0.78), shortening ICU and hospital stay but increasing bradycardia risk. Meta-analysis of 25 trials (n=3,997) demonstrates its efficacy in AKI prevention post-surgery, offering potential benefits in patient outcomes.
Effective management of intra-abdominal infections (IAIs) is crucial, with early diagnosis, proper source control, and timely antimicrobial therapy being key. Inappropriate antimicrobial treatment can lead to poor outcomes, including increased mortality. Optimizing antimicrobial prescriptions not only improves treatment effectiveness and patient safety but also helps…
Intra-abdominal infections cause significant morbidity and mortality in hospitals. Effective management involves rapid diagnostics, timely source control, and appropriate antimicrobial therapy. Key strategies include personalized treatment plans based on infection extent, pathogens, resistance risk, and patient condition. Hemodynamic and organ support with intravenous fluids and…
Revolutionary advancements like tracer-guided surgery with ICG fluorescence are reshaping surgical approaches, allowing for precise identification of anatomical structures, tissue perfusion assessment, and tumor detection. These innovations, coupled with the potential development of new tracers and imaging systems, signify a transformative era in surgery. A…
Vaginal approaches, once rare in general surgery, are now gaining traction as a minimally invasive option. This study provides a practical guide for general surgeons to proficiently utilize the vaginal route, covering key aspects like specimen extraction and cuff closure. Understanding and mastering this technique…
