A nomogram incorporating treatment data proved better than the AJCC staging system in predicting overall survival for gastroenteropancreatic neuroendocrine tumors. Key factors include sex, age, race, tumor location, and treatment modalities. Internal and external validation showed superior performance, advocating for individual risk evaluation to enhance patient outcomes and quality of life. Journal Article by Wu […]
Category: Sarcoma & rare tumors
Recommendations for Surgery in Advanced Small Bowel Neuroendocrine Tumours
Experts from the European Society of Endocrine Surgeons provide evidence-based recommendations for surgery in advanced small bowel neuroendocrine tumours, addressing key controversial topics such as primary tumour resection, cytoreduction, lymph node clearance, and management of unknown primary tumours. The recommendations, based on a systematic literature review of 84 papers due to lack of randomized controlled […]
Advancements in Medical Treatment for Pancreatic Neuroendocrine Tumors
This editorial highlights remarkable advancements in tailored medical treatment strategies for pancreatic neuroendocrine tumors. Cytoreductive surgery and somatostatin analogs are key in managing tumors, with additional treatment options available for refractory patients. Different subtypes require distinct therapeutic approaches, and ongoing research on the genetic basis and immunotherapies offers promising avenues for future patient outcomes. Editorial […]
High recurrence rates in ischiorectal fossa tumors despite surgical resection
An analysis of 34 cases of ischiorectal fossa tumors over a 30-year period found a high recurrence rate, with 35% of patients experiencing recurrence even after R0 resection. The median follow-up was 23 months, and the median time to recurrence was 6.5 months. Although there were no surgery-related mortalities, these results indicate the need for […]
Factors influencing treatment strategies for small pancreatic neuroendocrine neoplasms
Study evaluates optimal treatment strategies for nonfunctioning small pancreatic neuroendocrine neoplasms, highlighting the impact of tumor size and grade on lymph node metastasis, recurrence, and survival. Personalized treatment approaches considering tumor grading are recommended for heterogeneous nf-spnens. Tumor size >20 mm for net-g1 and >10 mm for net-g2 or higher are suggested thresholds for surgical […]
Site-specific features of gastric neuroendocrine neoplasms
Gastric neuroendocrine neoplasms (GNENs) exhibit unique characteristics based on their type. Incidence is rising, with GNENs including carcinomas and tumors. Different types require distinct approaches, with type III often needing locoregional and systemic treatments. Treatment data is limited, but insights from other neuroendocrine tumors are used. Enhanced understanding of molecular and clinical aspects is crucial […]
Impact of Case Volume on Sarcoma Prognostic Nomograms
Updated nomograms for primary retroperitoneal sarcoma patients differ in survival outcomes between high and low-volume centers. Case volume significantly influences overall and disease-free survival and nomogram performance. High-volume centers demonstrate better calibration than low-volume centers. Case volume should be considered in prognostic nomogram development for sarcoma patients. Journal Article by Callegaro D, Barretta F (…) […]
Improved Survival with Sequential Multimodal Therapy for Soft Tissue Sarcoma
Patients with advanced soft tissue sarcoma who receive sequential multimodal treatments with chemotherapy and surgery have better overall survival compared to those who only receive chemotherapy. Surgery appears to be more beneficial for patients who undergo chemotherapy first. These findings support the use of a treatment strategy that includes both surgery and chemotherapy in patients […]
Impact of Preoperative Anemia on Outcomes in GEP-NET Resections
Patients with preoperative anemia undergoing curative-intent resection for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) had higher rates of major complications and poorer long-term outcomes. Anemia was associated with worse overall survival, while postoperative transfusions were linked to lower overall survival and recurrence-free survival rates. Preoperative anemia affected around one-third of patients and significantly increased the risk of […]
Comparable Long-Term Survival Rates of Endoscopic Therapy and Surgical Resection for 2-5 cm Gastrointestinal Stromal Tumors
In a comparative study of endoscopic therapy (ET) versus surgical resection for 2-5 cm gastrointestinal stromal tumors, long-term outcomes showed no significant difference in overall or cancer-specific survival rates. After propensity score matching, both groups had comparable survival rates, suggesting that ET may be a viable treatment option for these tumors. Further research is needed […]