In the battle against adrenocortical carcinoma (ACC), researchers find surgical approach and extent matter less than tumor biology and margins in non-metastatic cases. A cohort study (2010–2019, 1,175 subjects) reveals laparoscopic surgery, often considered minimally invasive, correlates with worse survival in advanced disease (stage III). Positive margins negatively impact survival, while chemoradiation benefits those with […]
Category: General Surgery
Surgery Shines: A Viable Treatment Avenue for Stage IE Primary Thyroid Lymphoma
Surgery emerges as a viable treatment for stage IE primary thyroid lymphoma (PTL), with a cohort study of 1,596 patients (SEER database) and an external cohort of 38 patients (Shanghai, China). The 7.8-year SEER analysis showed no significant survival difference between surgery, surgery + radiotherapy/chemotherapy, and radiotherapy/chemotherapy alone. In the external cohort, surgery-alone exhibited comparable […]
Sex concordance increased specialist evaluations, potentially addressing under-referral issues in primary hyperparathyroidism.
Investigating primary hyperparathyroidism referrals, a study analyzed 1,100 patients and found that sex concordance (matching patient and practitioner sexes) correlated with increased specialist evaluations. Patients with concordant primary care practitioners had 32% higher odds of endocrinologist evaluation, and those with concordant endocrinologists had a 48% higher rate of surgeon evaluation. Stratified analysis revealed that sex […]
Missed Opportunities: Esophageal Adenocarcinoma Patients with Prior Colonoscopies Lack Timely Esophagogastroduodenoscopy
In the era of widespread colonoscopy, many patients later diagnosed with esophageal adenocarcinoma (EA) had prior screening colonoscopies, presenting missed opportunities for earlier detection. Among 221 referred patients, 49% had prior colonoscopies, yet only 18% had an esophagogastroduodenoscopy (EGD) before EA diagnosis. Most displayed gastroesophageal reflux disease symptoms or acid medication use during screening colonoscopy. […]
Similar Outcomes in Esophageal Cancer with Different Neoadjuvant Therapies
Comparing neoadjuvant radiochemotherapy protocols for resectable esophageal cancer, this study finds no significant differences in postoperative mortality, complications, or toxicity. Both PF-based and CROSS protocols demonstrate effectiveness and safety, with squamous cell carcinoma and favorable tumor grading independently predicting a higher pathological complete response rate. The battle of protocols concludes with similar outcomes, providing valuable […]
Surviving Biliary Sepsis: Unveiling 90-Day Mortality and Risks
Surviving biliary sepsis: A retrospective study in a cancer center unveils a 30.3% 90-day mortality rate, with factors like metastatic stage, biliary tract tumor compression, and multi-drug resistant bacteria influencing outcomes. Antibiotic de-escalation emerges as a safe strategy, linked with better survival. Beyond organ dysfunctions, the study emphasizes the impact of cancer stage, bacteria colonization, […]
Unveiling Hepatitis D: High Impact on Liver Health and a New Player in the Treatment Game
Hepatitis D Virus (HDV) hitchhikes on Hepatitis B Virus (HBV), impacting 12 to 72 million globally with accelerated liver disease progression. Chronic HDV-HBV infection, deadlier than HBV alone, leads to cirrhosis and hepatocellular carcinoma. Limited awareness hampers diagnosis, but the HBV vaccine offers prevention. Interferon alfa shows efficacy, while bulevirtide and lonafarnib present promising therapies. […]
Safe and Swift: Short-Stay Left Colectomy for Colon Cancer in the U.S.
Embracing modern surgical trends, this study scrutinizes the safety of brief hospital stays (≤24 hours) after left colectomy for colon cancer. Among 15,745 patients, a mere 1.87% experienced short stays, proving younger, healthier, and with lower morbidity rates than extended stays. Notably, short-stay patients exhibited comparable mortality and readmission rates to the 2-4 days group. […]
Thyroid-Stimulating Hormone Receptor Identified as a Promising Imaging Target for Differentiated Thyroid Cancer
In the realm of thyroid cancer, where iodine treatment falls short for some, researchers explored a new ally. The thyroid-stimulating hormone receptor (TSHR) took the spotlight, showing up in 62% of patients’ thyroid tissues. With a specially crafted radiolabeled compound, researchers witnessed TSHR’s potential for imaging differentiated thyroid cancer. This breakthrough hints at a fresh […]
Unlocking Hope for Neuroendocrine Carcinomas: Spheroid Screening Points to DNA Repair Inhibitors
In the quest for effective gastroenteropancreatic neuroendocrine carcinoma treatments, researchers unleashed patient-derived tumor spheroids. A dazzling 16 compounds, notably tyrosyl-DNA phosphodiesterase 1 inhibitors, emerged as fierce warriors against over 75% of these rare tumors. Cytarabine, a standout from the bunch, synergized with standard drugs, intensifying the battle against cancer cells. These findings spotlight a promising […]