Category: Upper Gastrointestinal Tract

A novel phoenix score reduces inconclusive GERD diagnoses

The development of the phoenix score significantly improved the classification of gastroesophageal reflux disease (GERD) cases. Among patients with total acid exposure time (AET) from 2 to 6%, the phoenix score decreased inconclusive diagnoses from 77.2% to 13.2% (p < 0.001). With an AUC of 0.957 and high sensitivity (94.4%) and specificity (95.8%), the score […]

Endoscopic submucosal dissection is safe for cancer in the remnant esophagus.

Endoscopic submucosal dissection (ESD) demonstrated safety and efficacy in treating superficial esophageal cancer within the remnant esophagus post-esophagectomy. In a study involving 47 patients, the procedure achieved an 86.4% complete resection rate and a 5-year disease-specific survival rate of 95.7%. Complications were minimal, with only one instance of postoperative bleeding. No local recurrence occurred during […]

Preoperative pulmonary training reduces complications in gastric cancer surgery

A randomized controlled trial involving 121 participants demonstrated that pulmonary-related training significantly lowered the incidence of postoperative pulmonary complications (PPCs) in gastric cancer patients. The training group had a PPC occurrence of 26.2% compared to 45.0% in the control group (p=0.031). Additionally, the training group experienced shorter hospital stays (8.69 days) and reduced hospitalization costs […]

G-POEM shows efficacy across various gastroparesis etiologies.

A meta-analysis of 15 studies with 982 patients demonstrated that gastric peroral endoscopic myotomy (G-POEM) is effective and safe for refractory gastroparesis regardless of etiology. Clinical success rates were 65% for diabetes, 70% for post-surgical, and 60% for idiopathic causes. G-POEM also improved Gastrointestinal Symptom Rating Scale Index (GCSI) scores significantly, with notable enhancements seen […]

Textbook outcome correlates with improved long-term survival in gastric cancer patients

Achieving textbook outcomes significantly enhances long-term survival among gastric cancer patients, with a notable 5-year conditional overall survival of 64.7% compared to 40.2% for those who did not meet these criteria (p < .001). Additionally, there is a compelling difference in 5-year conditional disease-free survival, recorded at 63.1% versus 37.6%, respectively (p < .001). This […]

Collaborative approach improves outcomes for rare cancer research

The ISGACA initiative successfully united over 60 medical centers globally, gathering data from 4,309 patients to enhance treatment strategies for non-pancreatic periampullary cancers. By establishing a structured methodology, the group facilitated nine publications, secured research grants, and initiated a prospective multicenter clinical trial. The collaborative efforts of ISGACA resulted in uniform definitions and classifications, showcasing […]

Multimodal nomogram enhances assessment of gastric cancer invasion depth

A combined nomogram integrating IVIM-DWI parameters and MRI characteristics achieved AUC values of 0.901 and 0.883 in training and validation cohorts, respectively. This approach effectively distinguishes between T1-2 and T3-4 stages of gastric cancer, addressing the challenge faced by radiologists in preoperative assessments. No significant difference was found between individual models, indicating the multimodal approach’s […]

Preoperative hypoalbuminemia increases mortality and complications post-esophagectomy.

Preoperative hypoalbuminemia is linked to higher 30-day mortality and complications after esophagectomy. In a study involving 803 patients with hypoalbuminemia compared to 7046 controls, matched analyses revealed mortality rates of 4.48% for those with low albumin versus 3.00% for those without. Findings suggest that recognizing and addressing preoperative hypoalbuminemia may be a cost-effective risk stratification […]

Complete pathologic response significantly enhances survival in esophageal adenocarcinoma

Achieving complete pathologic response in esophageal adenocarcinoma is linked to a notable survival benefit. Among 16,169 patients analyzed, 11.4% achieved this response, rising to 17.5% in those diagnosed from 2016 to 2020. Key independent predictors included female sex, black race, Hispanic ethnicity, and clinical stage II disease, while clinical stage III correlated with lower response […]