Category: Upper Gastrointestinal Tract

Lymph Node Metastasis and Survival in T1b Esophageal Adenocarcinoma Patients

Notable risk factors for lymph node metastasis in T1b esophageal adenocarcinoma include tumor size ≥20mm and poor differentiation. Endoscopic therapy (ET) showed comparable cancer-specific survival outcomes to surgery for selected cases. Age ≥65 years, ET, and chemoradiation therapy were associated with poorer overall survival. However, further large-scale studies are needed to confirm the lack of […]

Effectiveness of Magnetic Sphincter Augmentation in Gastro-Esophageal Reflux Disease

Magnetic sphincter augmentation (MSA) showed higher rates of discontinuing proton-pump inhibitors, increased patient satisfaction, and better functional outcomes compared to fundoplication in managing gastro-esophageal reflux disease. However, MSA had higher rates of dysphagia. The erosion and removal rates were low, but no difference was observed in re-intervention rates. MSA is a safe and effective procedure, […]

Risk Factors for Anastomotic Leak After Esophagectomy

An analysis of 4,331 patients undergoing esophagectomy revealed smoking, frailty index, white blood cell count, mckeown esophagectomy, and platelet counts were associated with anastomotic leak. Results showed increased odds of leak with smoking, frailty index scores of 1 or 2, and specific surgical techniques, while higher platelet counts were slightly protective. These findings offer crucial […]

Effects of Esophagectomy on Weight Loss and Glycolipid Profile in Type 2 Diabetes Patients

Esophagectomy induces weight loss and improves glucose and lipid metabolism in type 2 diabetes patients. Both diabetic and non-diabetic groups experience similar reductions in weight and BMI post-surgery. Fasting plasma glucose levels decrease significantly in the diabetic group, while HDL levels increase in the non-diabetic group. TG, LDL, and TC levels decrease significantly in both […]

Impact of Tumor Marker Regression Load Score on Prognosis of Gastric Cancer Patients

Novel findings suggest that the Tumor Marker Regression Load Score (TMRLS) is a significant independent prognostic factor for gastric cancer patients undergoing neoadjuvant chemotherapy and radical surgery. Patients with high TMRLS who received postoperative adjuvant chemotherapy showed better survival outcomes. The TMRLS-based nomogram demonstrated superior predictive performance compared to traditional staging methods. These results provide […]

Incidence of Morbidity and Mortality in Anti-reflux and Hiatal Hernia Surgery

This study reports historic morbidity and mortality rates in anti-reflux and hiatal hernia surgery, showing a 30-day morbidity rate of 18.2% and mortality rate of 0.2%, with most complications being minor. The 31-90-day period shows decreased rates. These findings suggest that while the surgeries have rare mortality, some patients may experience major complications, emphasizing the […]

Prognostic Value in Gastric Cancer Patients

The age-adjusted Charlson Comorbidity Index and sarcopenia are significant independent risk factors for prognosis in gastric cancer patients. A new prognostic score, ACCIS, combining these factors, accurately predicts prognosis and enhances predictive accuracy. Integration of ACCI score and sarcopenia improves prognostic predictions, leading to the development of a nomogram with a high concordance index for […]

Clinical Significance of C-Reactive Protein-Albumin-Lymphocyte Index in Gastric Cancer Patients

The preoperative C-reactive protein-albumin-lymphocyte (CAlly) index is an independent prognostic factor for overall and disease-free survival in patients with gastric cancer. It is also a valuable predictive marker for postoperative surgical site infection, highlighting its potential clinical significance in perioperative and oncologic management of gastric cancer patients. Journal Article by Okugawa Y, Ohi M (…) […]

Effectiveness of Laparoscopic Indocyanine Green Tracer-guided Lymphadenectomy for Locally Advanced Gastric Cancer

Indocyanine green (ICG) guidance significantly improves lymph node dissection quality in patients with locally advanced gastric cancer undergoing laparoscopic radical gastrectomy after neoadjuvant chemotherapy. ICG led to higher numbers of retrieved lymph nodes, reduced noncompliance rates, and improved lymphadenectomy quality for patients with complete response. Surgical outcomes were similar between ICG and non-ICG groups, suggesting […]

Optimal Management Strategy for Patients with Paraesophageal Hernia

Updated Markov model shows elective laparoscopic hernia repair increases life-years in individuals with paraesophageal hernia symptoms and Cameron lesions. Comorbid conditions impact life expectancy but do not change the preference for surgery over watchful waiting in most cases, except for the elderly without Cameron lesions. Individualized guidance for management of paraesophageal hernia patients can be […]