Newsletter
Every new paper in this field, in your inbox.
In an international cohort study of 1,874 patients with perforated peptic ulcer (PPU), researchers found a 30-day morbidity rate of 48.5% and a mortality rate of 9.3%. Key factors affecting these rates included age over 50, female gender, shock on admission, and acute kidney injury,…
A retrospective cohort study analyzing 1,317 emergency hiatal hernia repairs revealed that fundoplication significantly reduced 30-day complication (odds ratio [OR] 0.53, p < 0.001) and mortality rates (OR 0.55, p = 0.033) compared to gastric fixation. No significant differences were found regarding 30-day readmission (OR…
The study developed a prognostic nomogram for gastric cancer patients post-neoadjuvant chemotherapy and radical surgery, revealing promising results. The median progression-free survival was 43.8 months, and overall survival reached 61.2 months. The nomogram demonstrated excellent discrimination with a c-index of 0.689 and area under the…
Elevated interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels in serum and drainage fluid indicate infectious complications following minimally invasive gastric cancer surgery. Among 205 patients, pod 1 serum IL-6 levels above 47 pg/ml exhibited 74.1% sensitivity, while drainage fluid IL-6 levels over 14,750 pg/ml…
Significant causal effects of genetically predicted cholelithiasis, cholecystitis, and cholecystectomy on gastroesophageal reflux disease (GERD) were identified, with odds ratios of 1.04, 1.06, and 2.56, respectively. Additionally, the study confirmed a bidirectional relationship, where GERD also influences the likelihood of developing cholelithiasis and cholecystitis. Mediation…
Findings indicate that neoadjuvant chemotherapy (ctx) for resectable gastric cancer results in significantly longer overall survival (OS) compared to neoadjuvant chemoradiation (crtx). Analysis of 14,266 patients revealed a 20%-30% improvement in 5-year OS for the ctx group, despite a higher prevalence of complete pathological response…
A consensus reached by experts identified key quality performance indicators for management of oesophagogastric cancer, enhancing patient care and outcomes. The two-round modified Delphi process resulted in a standardized list which includes specialized multi-disciplinary discussions, pertinent imaging and staging procedures, as well as specific surgical…
In a study of 188 patients undergoing neoadjuvant therapy for locally advanced esophageal cancer, researchers developed predictive nomograms showing strong performance for estimating tumor regression grade (TRG) and ypTNM stage. Notably, 129 patients reached TRG grades 0-1, while 118 achieved ypTNM stage I. Five independent…
A study involving 203 gastric cancer patients revealed that total neoadjuvant therapy (TNT) resulted in a 5-year overall survival (OS) rate of 65.2% and a disease-specific survival (DSS) rate of 70.8%. Notably, patients achieving pathologic complete response (PCR) had significantly better outcomes, with 5-year OS…
The CHAMPS score proved highly effective in predicting mortality in patients with non-variceal upper gastrointestinal bleeding, showing an area under the receiver operating characteristic curve (AUROC) of 0.89. It significantly outperformed the Glasgow-Blatchford score (0.72) and AIM65 score (0.71). In low-risk categories, mortality and rebleeding…
