Among 97 patients with non-curative endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC), 73 underwent additional chemoradiotherapy (CRT). With a median follow-up of 71 months, recurrences were observed in 14% of patients. Lymphatic invasion was identified as an independent risk factor for recurrence. Notably, all patients who underwent surgery for recurrent disease survived, regardless […]
Category: Upper Gastrointestinal Tract
CA19-9 is a significant prognostic factor in stage III gastric cancer patients undergoing radical gastrectomy
The main result of this study is that preoperative and postoperative serum CA19-9 values are independent risk factors for predicting the prognosis in patients with stage III gastric cancer after curative gastrectomy. Patients with CA19-9 levels greater than 35 U/ml had significantly lower recurrence-free survival and overall survival rates compared to those with CA19-9 levels […]
Management Strategies for Refractory Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a common condition with increasing prevalence worldwide and a high economic burden. Despite proton pump inhibitor (PPI) therapy, a significant number of patients remain symptomatic. This review highlights the importance of differentiating between unproven GERD and refractory GERD, and provides a comprehensive overview of the diagnostic workup and personalized management […]
Adjuvant Nivolumab Shows Promising Results in Patients with Tumor-Positive Resection Margin Following Chemoradiotherapy and Esophagectomy
Approximately 4-9% of patients had a tumor-positive resection margin after neoadjuvant chemoradiotherapy (ncrt) and esophagectomy. Only a small proportion of patients received adjuvant therapy, despite the association of positive margins with decreased survival. However, a real-world study revealed that 61% of patients were treated with adjuvant immunotherapy (specifically nivolumab) in 2021-2022. Notably, patients who underwent […]
Discontinuous growth pattern is an independent adverse predictor of survival outcomes in esophageal adenocarcinoma.
Discontinuous growth (DG) in esophageal adenocarcinoma (EAC) is associated with adverse clinicopathologic features and worse patient outcomes. DG was found to be an independent adverse predictor of survival outcomes in EAC, even after adjusting for other factors such as tumor size and stage. This multi-institutional study highlights the significance of DG and emphasizes the need […]
Outcomes of Induction Chemotherapy and Esophagectomy for Advanced Esophageal Cancer
Induction chemotherapy followed by response evaluation and esophagectomy in patients with advanced esophageal cancer showed promising results in terms of survival. A total of 238 patients were treated with taxane/platinum-based chemotherapy, with 64.7% undergoing surgical exploration. Resection was performed in 53.4% of patients, resulting in a median survival of 26.3 months and a 5-year overall […]
Nomogram Combined Treatment Data is More Effective than AJCC Staging System for Predicting Overall Survival in GEP-NETs
Researchers conducted a study to develop and validate a nomogram for predicting overall survival (OS) in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Using data from the SEER registry, they identified key prognostic factors and compared the nomogram’s performance to the AJCC staging system. The results showed that the nomogram, which combined treatment data, had a […]
Improved ypStage Grouping System for Esophageal Squamous Cell Carcinoma Patients
A revised ypStage grouping system was proposed for esophageal squamous cell carcinoma patients who underwent neoadjuvant chemoradiotherapy followed by surgery. The new system adequately addressed the limitations of the existing American Joint Committee on Cancer (AJCC) system, showing improved prognostic relevance and higher discrimination ability. The study cohort included 501 patients in the development cohort […]
Book-Binding Technique (BBT) Shows Safe Intracorporeal Gastroduodenostomy in Totally Laparoscopic Distal Gastrectomy for Gastric Cancer
The book-binding technique (BBT) is a safe and feasible method for intracorporeal gastroduodenostomy in totally laparoscopic distal gastrectomy (TLDG) for patients with gastric malignancy. This retrospective study evaluated 188 patients who underwent TLDG with BBT reconstruction, showing low rates of anastomotic stenosis and leakage. The median time to the first diet was 3.1 days, and […]
Cost-Effective Management of Locally Advanced Gastric Cancer: Preoperative Chemotherapy Dominates
Based on a cost-effectiveness analysis, researchers found that PCT is the most cost-effective management modality for LAGC compared to upfront surgery (US). PCT yielded 3.11 quality-adjusted life-years (QALYs) at a cost of $40,792.16, while US yielded 3.15 QALYs at a cost of $55,575.57. The incremental cost-effectiveness ratio (ICER) was $369,585.25. Sensitivity analyses consistently favored PCT, […]